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Sub–100 nm Nanoparticle Upconcentration in Flow by Dielectrophoretic Forces

This paper presents a novel microfluidic chip for upconcentration of sub–100 nm nanoparticles in a flow using electrical forces generated by a DC or AC field. Two electrode designs were optimized using COMSOL Multiphysics and tested using particles with sizes as low as 47 nm. We show how inclined el...

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Detalles Bibliográficos
Autores principales: Dimaki, Maria, Olsen, Mark Holm, Rozlosnik, Noemi, Svendsen, Winnie E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9230564/
https://www.ncbi.nlm.nih.gov/pubmed/35744480
http://dx.doi.org/10.3390/mi13060866
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author Dimaki, Maria
Olsen, Mark Holm
Rozlosnik, Noemi
Svendsen, Winnie E.
author_facet Dimaki, Maria
Olsen, Mark Holm
Rozlosnik, Noemi
Svendsen, Winnie E.
author_sort Dimaki, Maria
collection PubMed
description This paper presents a novel microfluidic chip for upconcentration of sub–100 nm nanoparticles in a flow using electrical forces generated by a DC or AC field. Two electrode designs were optimized using COMSOL Multiphysics and tested using particles with sizes as low as 47 nm. We show how inclined electrodes with a zig-zag three-tooth configuration in a channel of 20 µm width are the ones generating the highest gradient and therefore the largest force. The design, based on AC dielectrophoresis, was shown to upconcentrate sub–100 nm particles by a factor of 11 using a flow rate of 2–25 µL/h. We present theoretical and experimental results and discuss how the chip design can easily be massively parallelized in order to increase throughput by a factor of at least 1250.
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spelling pubmed-92305642022-06-25 Sub–100 nm Nanoparticle Upconcentration in Flow by Dielectrophoretic Forces Dimaki, Maria Olsen, Mark Holm Rozlosnik, Noemi Svendsen, Winnie E. Micromachines (Basel) Article This paper presents a novel microfluidic chip for upconcentration of sub–100 nm nanoparticles in a flow using electrical forces generated by a DC or AC field. Two electrode designs were optimized using COMSOL Multiphysics and tested using particles with sizes as low as 47 nm. We show how inclined electrodes with a zig-zag three-tooth configuration in a channel of 20 µm width are the ones generating the highest gradient and therefore the largest force. The design, based on AC dielectrophoresis, was shown to upconcentrate sub–100 nm particles by a factor of 11 using a flow rate of 2–25 µL/h. We present theoretical and experimental results and discuss how the chip design can easily be massively parallelized in order to increase throughput by a factor of at least 1250. MDPI 2022-05-30 /pmc/articles/PMC9230564/ /pubmed/35744480 http://dx.doi.org/10.3390/mi13060866 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Dimaki, Maria
Olsen, Mark Holm
Rozlosnik, Noemi
Svendsen, Winnie E.
Sub–100 nm Nanoparticle Upconcentration in Flow by Dielectrophoretic Forces
title Sub–100 nm Nanoparticle Upconcentration in Flow by Dielectrophoretic Forces
title_full Sub–100 nm Nanoparticle Upconcentration in Flow by Dielectrophoretic Forces
title_fullStr Sub–100 nm Nanoparticle Upconcentration in Flow by Dielectrophoretic Forces
title_full_unstemmed Sub–100 nm Nanoparticle Upconcentration in Flow by Dielectrophoretic Forces
title_short Sub–100 nm Nanoparticle Upconcentration in Flow by Dielectrophoretic Forces
title_sort sub–100 nm nanoparticle upconcentration in flow by dielectrophoretic forces
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9230564/
https://www.ncbi.nlm.nih.gov/pubmed/35744480
http://dx.doi.org/10.3390/mi13060866
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