A 4/8 Subtype α-Conotoxin Vt1.27 Inhibits N-Type Calcium Channels With Potent Anti-Allodynic Effect

A novel 4/8 subtype α-conotoxin, Vt1.27 (NCCMFHTCPIDYSRFNC-NH(2)), was identified from Conus vitulinus in the South China Sea by RACE methods. The peptide was synthesized and structurally characterized. Similar to other α-conotoxins that target neuronal nicotinic acetylcholine receptor (nAChR) subty...

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Detalles Bibliográficos
Autores principales: Wang, Shuo, Bartels, Peter, Zhao, Cong, Yousuf, Arsalan, Liu, Zhuguo, Yu, Shuo, Bony, Anuja R., Ma, Xiaoli, Dai, Qin, Sun, Ting, Liu, Na, Yang, Mengke, Yu, Rilei, Du, Weihong, Adams, David J., Dai, Qiuyun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9230573/
https://www.ncbi.nlm.nih.gov/pubmed/35754473
http://dx.doi.org/10.3389/fphar.2022.881732

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