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C1q Gene Polymorphism Is Associated with Asymptomatic Bacteriuria in Patients with Type 2 Diabetes Mellitus

Background and Objectives: Asymptomatic bacteriuria (ASB) appears to have a higher prevalence in diabetics and has been associated with various genetic polymorphisms of the innate immune system. Single nucleotide polymorphisms (SNPs) of the C1q gene that encodes for the trigger molecule of the class...

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Autores principales: Matthiopoulou, Georgia, Zervou, Maria I., Stathopoulou, Chrysoula, Ioannou, Petros, Papadakis, John A., Daraki, Vasiliki N., Pappas, Angelos, Souris, Sotiris, Samonis, George, Goulielmos, George N., Kofteridis, Diamantis P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9230576/
https://www.ncbi.nlm.nih.gov/pubmed/35744013
http://dx.doi.org/10.3390/medicina58060750
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author Matthiopoulou, Georgia
Zervou, Maria I.
Stathopoulou, Chrysoula
Ioannou, Petros
Papadakis, John A.
Daraki, Vasiliki N.
Pappas, Angelos
Souris, Sotiris
Samonis, George
Goulielmos, George N.
Kofteridis, Diamantis P.
author_facet Matthiopoulou, Georgia
Zervou, Maria I.
Stathopoulou, Chrysoula
Ioannou, Petros
Papadakis, John A.
Daraki, Vasiliki N.
Pappas, Angelos
Souris, Sotiris
Samonis, George
Goulielmos, George N.
Kofteridis, Diamantis P.
author_sort Matthiopoulou, Georgia
collection PubMed
description Background and Objectives: Asymptomatic bacteriuria (ASB) appears to have a higher prevalence in diabetics and has been associated with various genetic polymorphisms of the innate immune system. Single nucleotide polymorphisms (SNPs) of the C1q gene that encodes for the trigger molecule of the classical complement pathway increase the risk of bacterial infections as well as other diseases. In the present study, we sought to investigate the association of C1q rs292001 (G > A) SNP with ASB in patients with type 2 diabetes (T2D). Materials and Methods: In this case-control study, performed at the University and the Venizeleion General Hospital of Heraklion, Crete, Greece, 75 adult male and female Cretan patients with T2D and ASB and 75 adult male and female Cretan patients with T2D but without ASB were enrolled and genotyped for rs292001 SNP of C1q gene. Genetic analysis was based on the polymerase chain reaction (PCR) and restriction fragment length polymorphisms (RLFPs) methods. Results: Τhe frequency of homozygotes for the G/G genotype of C1q rs292001 was significantly higher in patients with T2D and ASB than in the control group (p-value = 0.0480, OR = 2.952, 95% CI: 1.052–7.542). Conclusions: Τhe present study provides the first evidence of an association between the C1q rs292001 SNP and an increased susceptibility for ASB in an adult Cretan population with T2D, thus suggesting that this SNP can be encountered as a risk factor for the presence of ASB in patients with T2D.
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spelling pubmed-92305762022-06-25 C1q Gene Polymorphism Is Associated with Asymptomatic Bacteriuria in Patients with Type 2 Diabetes Mellitus Matthiopoulou, Georgia Zervou, Maria I. Stathopoulou, Chrysoula Ioannou, Petros Papadakis, John A. Daraki, Vasiliki N. Pappas, Angelos Souris, Sotiris Samonis, George Goulielmos, George N. Kofteridis, Diamantis P. Medicina (Kaunas) Article Background and Objectives: Asymptomatic bacteriuria (ASB) appears to have a higher prevalence in diabetics and has been associated with various genetic polymorphisms of the innate immune system. Single nucleotide polymorphisms (SNPs) of the C1q gene that encodes for the trigger molecule of the classical complement pathway increase the risk of bacterial infections as well as other diseases. In the present study, we sought to investigate the association of C1q rs292001 (G > A) SNP with ASB in patients with type 2 diabetes (T2D). Materials and Methods: In this case-control study, performed at the University and the Venizeleion General Hospital of Heraklion, Crete, Greece, 75 adult male and female Cretan patients with T2D and ASB and 75 adult male and female Cretan patients with T2D but without ASB were enrolled and genotyped for rs292001 SNP of C1q gene. Genetic analysis was based on the polymerase chain reaction (PCR) and restriction fragment length polymorphisms (RLFPs) methods. Results: Τhe frequency of homozygotes for the G/G genotype of C1q rs292001 was significantly higher in patients with T2D and ASB than in the control group (p-value = 0.0480, OR = 2.952, 95% CI: 1.052–7.542). Conclusions: Τhe present study provides the first evidence of an association between the C1q rs292001 SNP and an increased susceptibility for ASB in an adult Cretan population with T2D, thus suggesting that this SNP can be encountered as a risk factor for the presence of ASB in patients with T2D. MDPI 2022-05-31 /pmc/articles/PMC9230576/ /pubmed/35744013 http://dx.doi.org/10.3390/medicina58060750 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Matthiopoulou, Georgia
Zervou, Maria I.
Stathopoulou, Chrysoula
Ioannou, Petros
Papadakis, John A.
Daraki, Vasiliki N.
Pappas, Angelos
Souris, Sotiris
Samonis, George
Goulielmos, George N.
Kofteridis, Diamantis P.
C1q Gene Polymorphism Is Associated with Asymptomatic Bacteriuria in Patients with Type 2 Diabetes Mellitus
title C1q Gene Polymorphism Is Associated with Asymptomatic Bacteriuria in Patients with Type 2 Diabetes Mellitus
title_full C1q Gene Polymorphism Is Associated with Asymptomatic Bacteriuria in Patients with Type 2 Diabetes Mellitus
title_fullStr C1q Gene Polymorphism Is Associated with Asymptomatic Bacteriuria in Patients with Type 2 Diabetes Mellitus
title_full_unstemmed C1q Gene Polymorphism Is Associated with Asymptomatic Bacteriuria in Patients with Type 2 Diabetes Mellitus
title_short C1q Gene Polymorphism Is Associated with Asymptomatic Bacteriuria in Patients with Type 2 Diabetes Mellitus
title_sort c1q gene polymorphism is associated with asymptomatic bacteriuria in patients with type 2 diabetes mellitus
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9230576/
https://www.ncbi.nlm.nih.gov/pubmed/35744013
http://dx.doi.org/10.3390/medicina58060750
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