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Calcium Supplementation, Risk of Cardiovascular Diseases, and Mortality: A Real-World Study of the Korean National Health Insurance Service Data

Few studies have investigated the effects of calcium supplementation on cardiovascular outcomes in individuals with low calcium intake in real-world settings. This study examined the association between calcium supplementation and cardiovascular outcomes in the Korean population in a real-world sett...

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Autores principales: Park, Jae-Min, Lee, Bora, Kim, Young-Sang, Hong, Kyung-Won, Park, Yon Chul, Shin, Dong Hyeok, Kim, Yonghwan, Han, Kunhee, Kim, Kwangyoon, Shin, Junghwa, Kim, Mina, Kim, Bom-Taeck
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9230596/
https://www.ncbi.nlm.nih.gov/pubmed/35745268
http://dx.doi.org/10.3390/nu14122538
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author Park, Jae-Min
Lee, Bora
Kim, Young-Sang
Hong, Kyung-Won
Park, Yon Chul
Shin, Dong Hyeok
Kim, Yonghwan
Han, Kunhee
Kim, Kwangyoon
Shin, Junghwa
Kim, Mina
Kim, Bom-Taeck
author_facet Park, Jae-Min
Lee, Bora
Kim, Young-Sang
Hong, Kyung-Won
Park, Yon Chul
Shin, Dong Hyeok
Kim, Yonghwan
Han, Kunhee
Kim, Kwangyoon
Shin, Junghwa
Kim, Mina
Kim, Bom-Taeck
author_sort Park, Jae-Min
collection PubMed
description Few studies have investigated the effects of calcium supplementation on cardiovascular outcomes in individuals with low calcium intake in real-world settings. This study examined the association between calcium supplementation and cardiovascular outcomes in the Korean population in a real-world setting. This large retrospective cohort study included patients aged ≥45 years first prescribed calcium supplements in 2010. Age- and sex-matched controls were recruited among those who had no prescription for calcium supplements. Longitudinal data were collected on 31 December 2018. Kaplan–Meier estimation and Cox proportional hazard regression analysis were performed. The cumulative incidence of acute myocardial infarction, ischemic stroke, and death was significantly higher in the calcium supplementation group than in the control group (p < 0.05 by log-rank test). The calcium supplementation group had a significantly higher risk of myocardial infarction, ischemic stroke, and death than the control group. Compared to the control group, the hazard ratios (95% confidence intervals) of the incidence of myocardial infarction, stroke, and death in the supplementation group were 1.14 (1.03–1.27), 1.12 (1.05–1.20), and 1.40 (1.32–1.50), respectively, after adjusting for confounding variables. Considering the associated cardiovascular risk, calcium supplementation for osteoporosis treatment should be administered cautiously.
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spelling pubmed-92305962022-06-25 Calcium Supplementation, Risk of Cardiovascular Diseases, and Mortality: A Real-World Study of the Korean National Health Insurance Service Data Park, Jae-Min Lee, Bora Kim, Young-Sang Hong, Kyung-Won Park, Yon Chul Shin, Dong Hyeok Kim, Yonghwan Han, Kunhee Kim, Kwangyoon Shin, Junghwa Kim, Mina Kim, Bom-Taeck Nutrients Article Few studies have investigated the effects of calcium supplementation on cardiovascular outcomes in individuals with low calcium intake in real-world settings. This study examined the association between calcium supplementation and cardiovascular outcomes in the Korean population in a real-world setting. This large retrospective cohort study included patients aged ≥45 years first prescribed calcium supplements in 2010. Age- and sex-matched controls were recruited among those who had no prescription for calcium supplements. Longitudinal data were collected on 31 December 2018. Kaplan–Meier estimation and Cox proportional hazard regression analysis were performed. The cumulative incidence of acute myocardial infarction, ischemic stroke, and death was significantly higher in the calcium supplementation group than in the control group (p < 0.05 by log-rank test). The calcium supplementation group had a significantly higher risk of myocardial infarction, ischemic stroke, and death than the control group. Compared to the control group, the hazard ratios (95% confidence intervals) of the incidence of myocardial infarction, stroke, and death in the supplementation group were 1.14 (1.03–1.27), 1.12 (1.05–1.20), and 1.40 (1.32–1.50), respectively, after adjusting for confounding variables. Considering the associated cardiovascular risk, calcium supplementation for osteoporosis treatment should be administered cautiously. MDPI 2022-06-18 /pmc/articles/PMC9230596/ /pubmed/35745268 http://dx.doi.org/10.3390/nu14122538 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Park, Jae-Min
Lee, Bora
Kim, Young-Sang
Hong, Kyung-Won
Park, Yon Chul
Shin, Dong Hyeok
Kim, Yonghwan
Han, Kunhee
Kim, Kwangyoon
Shin, Junghwa
Kim, Mina
Kim, Bom-Taeck
Calcium Supplementation, Risk of Cardiovascular Diseases, and Mortality: A Real-World Study of the Korean National Health Insurance Service Data
title Calcium Supplementation, Risk of Cardiovascular Diseases, and Mortality: A Real-World Study of the Korean National Health Insurance Service Data
title_full Calcium Supplementation, Risk of Cardiovascular Diseases, and Mortality: A Real-World Study of the Korean National Health Insurance Service Data
title_fullStr Calcium Supplementation, Risk of Cardiovascular Diseases, and Mortality: A Real-World Study of the Korean National Health Insurance Service Data
title_full_unstemmed Calcium Supplementation, Risk of Cardiovascular Diseases, and Mortality: A Real-World Study of the Korean National Health Insurance Service Data
title_short Calcium Supplementation, Risk of Cardiovascular Diseases, and Mortality: A Real-World Study of the Korean National Health Insurance Service Data
title_sort calcium supplementation, risk of cardiovascular diseases, and mortality: a real-world study of the korean national health insurance service data
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9230596/
https://www.ncbi.nlm.nih.gov/pubmed/35745268
http://dx.doi.org/10.3390/nu14122538
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