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Repurposing an In Vitro Measles Virus Dissemination Assay for Screening of Antiviral Compounds
Measles virus (MV) is a highly contagious respiratory virus responsible for outbreaks associated with significant morbidity and mortality among children and young adults. Although safe and effective measles vaccines are available, the COVID-19 pandemic has resulted in vaccination coverage gaps that...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9230603/ https://www.ncbi.nlm.nih.gov/pubmed/35746658 http://dx.doi.org/10.3390/v14061186 |
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author | Schmitz, Katharina S. Lange, Mona V. Gommers, Lennert Handrejk, Kim Porter, Danielle P. Alabi, Christopher A. Moscona, Anne Porotto, Matteo de Vries, Rory D. de Swart, Rik L. |
author_facet | Schmitz, Katharina S. Lange, Mona V. Gommers, Lennert Handrejk, Kim Porter, Danielle P. Alabi, Christopher A. Moscona, Anne Porotto, Matteo de Vries, Rory D. de Swart, Rik L. |
author_sort | Schmitz, Katharina S. |
collection | PubMed |
description | Measles virus (MV) is a highly contagious respiratory virus responsible for outbreaks associated with significant morbidity and mortality among children and young adults. Although safe and effective measles vaccines are available, the COVID-19 pandemic has resulted in vaccination coverage gaps that may lead to the resurgence of measles when restrictions are lifted. This puts individuals who cannot be vaccinated, such as young infants and immunocompromised individuals, at risk. Therapeutic interventions are complicated by the long incubation time of measles, resulting in a narrow treatment window. At present, the only available WHO-advised option is treatment with intravenous immunoglobulins, although this is not approved as standard of care. Antivirals against measles may contribute to intervention strategies to limit the impact of future outbreaks. Here, we review previously described antivirals and antiviral assays, evaluate the antiviral efficacy of a number of compounds to inhibit MV dissemination in vitro, and discuss potential application in specific target populations. We conclude that broadly reactive antivirals could strengthen existing intervention strategies to limit the impact of measles outbreaks. |
format | Online Article Text |
id | pubmed-9230603 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-92306032022-06-25 Repurposing an In Vitro Measles Virus Dissemination Assay for Screening of Antiviral Compounds Schmitz, Katharina S. Lange, Mona V. Gommers, Lennert Handrejk, Kim Porter, Danielle P. Alabi, Christopher A. Moscona, Anne Porotto, Matteo de Vries, Rory D. de Swart, Rik L. Viruses Article Measles virus (MV) is a highly contagious respiratory virus responsible for outbreaks associated with significant morbidity and mortality among children and young adults. Although safe and effective measles vaccines are available, the COVID-19 pandemic has resulted in vaccination coverage gaps that may lead to the resurgence of measles when restrictions are lifted. This puts individuals who cannot be vaccinated, such as young infants and immunocompromised individuals, at risk. Therapeutic interventions are complicated by the long incubation time of measles, resulting in a narrow treatment window. At present, the only available WHO-advised option is treatment with intravenous immunoglobulins, although this is not approved as standard of care. Antivirals against measles may contribute to intervention strategies to limit the impact of future outbreaks. Here, we review previously described antivirals and antiviral assays, evaluate the antiviral efficacy of a number of compounds to inhibit MV dissemination in vitro, and discuss potential application in specific target populations. We conclude that broadly reactive antivirals could strengthen existing intervention strategies to limit the impact of measles outbreaks. MDPI 2022-05-29 /pmc/articles/PMC9230603/ /pubmed/35746658 http://dx.doi.org/10.3390/v14061186 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Schmitz, Katharina S. Lange, Mona V. Gommers, Lennert Handrejk, Kim Porter, Danielle P. Alabi, Christopher A. Moscona, Anne Porotto, Matteo de Vries, Rory D. de Swart, Rik L. Repurposing an In Vitro Measles Virus Dissemination Assay for Screening of Antiviral Compounds |
title | Repurposing an In Vitro Measles Virus Dissemination Assay for Screening of Antiviral Compounds |
title_full | Repurposing an In Vitro Measles Virus Dissemination Assay for Screening of Antiviral Compounds |
title_fullStr | Repurposing an In Vitro Measles Virus Dissemination Assay for Screening of Antiviral Compounds |
title_full_unstemmed | Repurposing an In Vitro Measles Virus Dissemination Assay for Screening of Antiviral Compounds |
title_short | Repurposing an In Vitro Measles Virus Dissemination Assay for Screening of Antiviral Compounds |
title_sort | repurposing an in vitro measles virus dissemination assay for screening of antiviral compounds |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9230603/ https://www.ncbi.nlm.nih.gov/pubmed/35746658 http://dx.doi.org/10.3390/v14061186 |
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