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NMR-Based Metabolomics in Differential Diagnosis of Chronic Kidney Disease (CKD) Subtypes
Chronic Kidney Disease (CKD) is considered as a major public health problem as it can lead to end-stage kidney failure, which requires replacement therapy. A prompt and accurate diagnosis, along with the appropriate treatment, can delay CKD’s progression, significantly. Herein, we sought to determin...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9230636/ https://www.ncbi.nlm.nih.gov/pubmed/35736423 http://dx.doi.org/10.3390/metabo12060490 |
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author | Chasapi, Styliani A. Karagkouni, Evdokia Kalavrizioti, Dimitra Vamvakas, Sotirios Zompra, Aikaterini Takis, Panteleimon G. Goumenos, Dimitrios S. Spyroulias, Georgios A. |
author_facet | Chasapi, Styliani A. Karagkouni, Evdokia Kalavrizioti, Dimitra Vamvakas, Sotirios Zompra, Aikaterini Takis, Panteleimon G. Goumenos, Dimitrios S. Spyroulias, Georgios A. |
author_sort | Chasapi, Styliani A. |
collection | PubMed |
description | Chronic Kidney Disease (CKD) is considered as a major public health problem as it can lead to end-stage kidney failure, which requires replacement therapy. A prompt and accurate diagnosis, along with the appropriate treatment, can delay CKD’s progression, significantly. Herein, we sought to determine whether CKD etiology can be reflected in urine metabolomics during its early stage. This is achieved through the analysis of the urine metabolic fingerprint from 108 CKD patients by means of Nuclear Magnetic Resonance (NMR) spectroscopy metabolomic analysis. We report the first NMR—metabolomics data regarding the three most common etiologies of CKD: Chronic Glomerulonephritis (IgA and Membranous Nephropathy), Diabetic Nephropathy (DN) and Hypertensive Nephrosclerosis (HN). Analysis aided a moderate glomerulonephritis clustering, providing characterization of the metabolic fluctuations between the CKD subtypes and control disease. The urine metabolome of IgA Nephropathy reveals a specific metabolism, reflecting its different etiology or origin and is useful for determining the origin of the disease. In contrast, urine metabolomes from DN and HN patients did not reveal any indicative metabolic pattern, which is consistent with their fused clinical phenotype. These findings may contribute to improving diagnostics and prognostic approaches for CKD, as well as improving our understanding of its pathology. |
format | Online Article Text |
id | pubmed-9230636 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-92306362022-06-25 NMR-Based Metabolomics in Differential Diagnosis of Chronic Kidney Disease (CKD) Subtypes Chasapi, Styliani A. Karagkouni, Evdokia Kalavrizioti, Dimitra Vamvakas, Sotirios Zompra, Aikaterini Takis, Panteleimon G. Goumenos, Dimitrios S. Spyroulias, Georgios A. Metabolites Article Chronic Kidney Disease (CKD) is considered as a major public health problem as it can lead to end-stage kidney failure, which requires replacement therapy. A prompt and accurate diagnosis, along with the appropriate treatment, can delay CKD’s progression, significantly. Herein, we sought to determine whether CKD etiology can be reflected in urine metabolomics during its early stage. This is achieved through the analysis of the urine metabolic fingerprint from 108 CKD patients by means of Nuclear Magnetic Resonance (NMR) spectroscopy metabolomic analysis. We report the first NMR—metabolomics data regarding the three most common etiologies of CKD: Chronic Glomerulonephritis (IgA and Membranous Nephropathy), Diabetic Nephropathy (DN) and Hypertensive Nephrosclerosis (HN). Analysis aided a moderate glomerulonephritis clustering, providing characterization of the metabolic fluctuations between the CKD subtypes and control disease. The urine metabolome of IgA Nephropathy reveals a specific metabolism, reflecting its different etiology or origin and is useful for determining the origin of the disease. In contrast, urine metabolomes from DN and HN patients did not reveal any indicative metabolic pattern, which is consistent with their fused clinical phenotype. These findings may contribute to improving diagnostics and prognostic approaches for CKD, as well as improving our understanding of its pathology. MDPI 2022-05-28 /pmc/articles/PMC9230636/ /pubmed/35736423 http://dx.doi.org/10.3390/metabo12060490 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Chasapi, Styliani A. Karagkouni, Evdokia Kalavrizioti, Dimitra Vamvakas, Sotirios Zompra, Aikaterini Takis, Panteleimon G. Goumenos, Dimitrios S. Spyroulias, Georgios A. NMR-Based Metabolomics in Differential Diagnosis of Chronic Kidney Disease (CKD) Subtypes |
title | NMR-Based Metabolomics in Differential Diagnosis of Chronic Kidney Disease (CKD) Subtypes |
title_full | NMR-Based Metabolomics in Differential Diagnosis of Chronic Kidney Disease (CKD) Subtypes |
title_fullStr | NMR-Based Metabolomics in Differential Diagnosis of Chronic Kidney Disease (CKD) Subtypes |
title_full_unstemmed | NMR-Based Metabolomics in Differential Diagnosis of Chronic Kidney Disease (CKD) Subtypes |
title_short | NMR-Based Metabolomics in Differential Diagnosis of Chronic Kidney Disease (CKD) Subtypes |
title_sort | nmr-based metabolomics in differential diagnosis of chronic kidney disease (ckd) subtypes |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9230636/ https://www.ncbi.nlm.nih.gov/pubmed/35736423 http://dx.doi.org/10.3390/metabo12060490 |
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