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NMR-Based Metabolomics in Differential Diagnosis of Chronic Kidney Disease (CKD) Subtypes

Chronic Kidney Disease (CKD) is considered as a major public health problem as it can lead to end-stage kidney failure, which requires replacement therapy. A prompt and accurate diagnosis, along with the appropriate treatment, can delay CKD’s progression, significantly. Herein, we sought to determin...

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Autores principales: Chasapi, Styliani A., Karagkouni, Evdokia, Kalavrizioti, Dimitra, Vamvakas, Sotirios, Zompra, Aikaterini, Takis, Panteleimon G., Goumenos, Dimitrios S., Spyroulias, Georgios A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9230636/
https://www.ncbi.nlm.nih.gov/pubmed/35736423
http://dx.doi.org/10.3390/metabo12060490
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author Chasapi, Styliani A.
Karagkouni, Evdokia
Kalavrizioti, Dimitra
Vamvakas, Sotirios
Zompra, Aikaterini
Takis, Panteleimon G.
Goumenos, Dimitrios S.
Spyroulias, Georgios A.
author_facet Chasapi, Styliani A.
Karagkouni, Evdokia
Kalavrizioti, Dimitra
Vamvakas, Sotirios
Zompra, Aikaterini
Takis, Panteleimon G.
Goumenos, Dimitrios S.
Spyroulias, Georgios A.
author_sort Chasapi, Styliani A.
collection PubMed
description Chronic Kidney Disease (CKD) is considered as a major public health problem as it can lead to end-stage kidney failure, which requires replacement therapy. A prompt and accurate diagnosis, along with the appropriate treatment, can delay CKD’s progression, significantly. Herein, we sought to determine whether CKD etiology can be reflected in urine metabolomics during its early stage. This is achieved through the analysis of the urine metabolic fingerprint from 108 CKD patients by means of Nuclear Magnetic Resonance (NMR) spectroscopy metabolomic analysis. We report the first NMR—metabolomics data regarding the three most common etiologies of CKD: Chronic Glomerulonephritis (IgA and Membranous Nephropathy), Diabetic Nephropathy (DN) and Hypertensive Nephrosclerosis (HN). Analysis aided a moderate glomerulonephritis clustering, providing characterization of the metabolic fluctuations between the CKD subtypes and control disease. The urine metabolome of IgA Nephropathy reveals a specific metabolism, reflecting its different etiology or origin and is useful for determining the origin of the disease. In contrast, urine metabolomes from DN and HN patients did not reveal any indicative metabolic pattern, which is consistent with their fused clinical phenotype. These findings may contribute to improving diagnostics and prognostic approaches for CKD, as well as improving our understanding of its pathology.
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spelling pubmed-92306362022-06-25 NMR-Based Metabolomics in Differential Diagnosis of Chronic Kidney Disease (CKD) Subtypes Chasapi, Styliani A. Karagkouni, Evdokia Kalavrizioti, Dimitra Vamvakas, Sotirios Zompra, Aikaterini Takis, Panteleimon G. Goumenos, Dimitrios S. Spyroulias, Georgios A. Metabolites Article Chronic Kidney Disease (CKD) is considered as a major public health problem as it can lead to end-stage kidney failure, which requires replacement therapy. A prompt and accurate diagnosis, along with the appropriate treatment, can delay CKD’s progression, significantly. Herein, we sought to determine whether CKD etiology can be reflected in urine metabolomics during its early stage. This is achieved through the analysis of the urine metabolic fingerprint from 108 CKD patients by means of Nuclear Magnetic Resonance (NMR) spectroscopy metabolomic analysis. We report the first NMR—metabolomics data regarding the three most common etiologies of CKD: Chronic Glomerulonephritis (IgA and Membranous Nephropathy), Diabetic Nephropathy (DN) and Hypertensive Nephrosclerosis (HN). Analysis aided a moderate glomerulonephritis clustering, providing characterization of the metabolic fluctuations between the CKD subtypes and control disease. The urine metabolome of IgA Nephropathy reveals a specific metabolism, reflecting its different etiology or origin and is useful for determining the origin of the disease. In contrast, urine metabolomes from DN and HN patients did not reveal any indicative metabolic pattern, which is consistent with their fused clinical phenotype. These findings may contribute to improving diagnostics and prognostic approaches for CKD, as well as improving our understanding of its pathology. MDPI 2022-05-28 /pmc/articles/PMC9230636/ /pubmed/35736423 http://dx.doi.org/10.3390/metabo12060490 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Chasapi, Styliani A.
Karagkouni, Evdokia
Kalavrizioti, Dimitra
Vamvakas, Sotirios
Zompra, Aikaterini
Takis, Panteleimon G.
Goumenos, Dimitrios S.
Spyroulias, Georgios A.
NMR-Based Metabolomics in Differential Diagnosis of Chronic Kidney Disease (CKD) Subtypes
title NMR-Based Metabolomics in Differential Diagnosis of Chronic Kidney Disease (CKD) Subtypes
title_full NMR-Based Metabolomics in Differential Diagnosis of Chronic Kidney Disease (CKD) Subtypes
title_fullStr NMR-Based Metabolomics in Differential Diagnosis of Chronic Kidney Disease (CKD) Subtypes
title_full_unstemmed NMR-Based Metabolomics in Differential Diagnosis of Chronic Kidney Disease (CKD) Subtypes
title_short NMR-Based Metabolomics in Differential Diagnosis of Chronic Kidney Disease (CKD) Subtypes
title_sort nmr-based metabolomics in differential diagnosis of chronic kidney disease (ckd) subtypes
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9230636/
https://www.ncbi.nlm.nih.gov/pubmed/35736423
http://dx.doi.org/10.3390/metabo12060490
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