Discovery of GSK3β Inhibitors through In Silico Prediction-and-Experiment Cycling Strategy, and Biological Evaluation

Direct inhibitors of glycogen synthase kinase 3β (GSK3β) have been investigated and reported for the past 20 years. In the search for novel scaffold inhibitors, 3000 compounds were selected through structure-based virtual screening (SBVS), and then high-throughput enzyme screening was performed. Amo...

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Detalles Bibliográficos
Autores principales: Lee, Yuno, Yoon, Sae-Bom, Hong, Hyowon, Kim, Hyun Young, Jung, Daeyoung, Moon, Byoung-San, Park, Woo-Kyu, Lee, Sunkyung, Kwon, Hyukjin, Park, Jihyeong, Cho, Heeyeong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9230645/
https://www.ncbi.nlm.nih.gov/pubmed/35744952
http://dx.doi.org/10.3390/molecules27123825

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9230645/
https://www.ncbi.nlm.nih.gov/pubmed/35744952
http://dx.doi.org/10.3390/molecules27123825

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