Youssoufenes A2 and A3, Antibiotic Dimeric Cinnamoyl Lipids from the ΔdtlA Mutant of a Marine-Derived Streptomyces Strain

Two new dimeric cinnamoyl lipids (CL) featuring with an unusual dearomatic carbon-bridge, named youssoufenes A2 (1) and A3 (2), were isolated from the ΔdtlA mutant strain of marine-derived Streptomyces youssoufiensis OUC6819. Structures of the isolated compounds were elucidated based on extensive MS...

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Autores principales: Liu, Jing, Li, Huayue, Liu, Zengzhi, Li, Tong, Xiao, Fei, Li, Wenli
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9230751/
https://www.ncbi.nlm.nih.gov/pubmed/35736197
http://dx.doi.org/10.3390/md20060394
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author Liu, Jing
Li, Huayue
Liu, Zengzhi
Li, Tong
Xiao, Fei
Li, Wenli
author_facet Liu, Jing
Li, Huayue
Liu, Zengzhi
Li, Tong
Xiao, Fei
Li, Wenli
author_sort Liu, Jing
collection PubMed
description Two new dimeric cinnamoyl lipids (CL) featuring with an unusual dearomatic carbon-bridge, named youssoufenes A2 (1) and A3 (2), were isolated from the ΔdtlA mutant strain of marine-derived Streptomyces youssoufiensis OUC6819. Structures of the isolated compounds were elucidated based on extensive MS and NMR spectroscopic analyses, and their absolute configurations were determined by combination of the long-range NOE-based (1)H-(1)H distance measurements and ECD calculations. Compounds 1 and 2 exhibited moderate growth inhibition against multi-drug-resistant Enterococcus faecalis CCARM 5172 with an MIC value of 22.2 μM.
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spelling pubmed-92307512022-06-25 Youssoufenes A2 and A3, Antibiotic Dimeric Cinnamoyl Lipids from the ΔdtlA Mutant of a Marine-Derived Streptomyces Strain Liu, Jing Li, Huayue Liu, Zengzhi Li, Tong Xiao, Fei Li, Wenli Mar Drugs Article Two new dimeric cinnamoyl lipids (CL) featuring with an unusual dearomatic carbon-bridge, named youssoufenes A2 (1) and A3 (2), were isolated from the ΔdtlA mutant strain of marine-derived Streptomyces youssoufiensis OUC6819. Structures of the isolated compounds were elucidated based on extensive MS and NMR spectroscopic analyses, and their absolute configurations were determined by combination of the long-range NOE-based (1)H-(1)H distance measurements and ECD calculations. Compounds 1 and 2 exhibited moderate growth inhibition against multi-drug-resistant Enterococcus faecalis CCARM 5172 with an MIC value of 22.2 μM. MDPI 2022-06-15 /pmc/articles/PMC9230751/ /pubmed/35736197 http://dx.doi.org/10.3390/md20060394 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Liu, Jing
Li, Huayue
Liu, Zengzhi
Li, Tong
Xiao, Fei
Li, Wenli
Youssoufenes A2 and A3, Antibiotic Dimeric Cinnamoyl Lipids from the ΔdtlA Mutant of a Marine-Derived Streptomyces Strain
title Youssoufenes A2 and A3, Antibiotic Dimeric Cinnamoyl Lipids from the ΔdtlA Mutant of a Marine-Derived Streptomyces Strain
title_full Youssoufenes A2 and A3, Antibiotic Dimeric Cinnamoyl Lipids from the ΔdtlA Mutant of a Marine-Derived Streptomyces Strain
title_fullStr Youssoufenes A2 and A3, Antibiotic Dimeric Cinnamoyl Lipids from the ΔdtlA Mutant of a Marine-Derived Streptomyces Strain
title_full_unstemmed Youssoufenes A2 and A3, Antibiotic Dimeric Cinnamoyl Lipids from the ΔdtlA Mutant of a Marine-Derived Streptomyces Strain
title_short Youssoufenes A2 and A3, Antibiotic Dimeric Cinnamoyl Lipids from the ΔdtlA Mutant of a Marine-Derived Streptomyces Strain
title_sort youssoufenes a2 and a3, antibiotic dimeric cinnamoyl lipids from the δdtla mutant of a marine-derived streptomyces strain
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9230751/
https://www.ncbi.nlm.nih.gov/pubmed/35736197
http://dx.doi.org/10.3390/md20060394
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