Heteroleptic Copper(I)-Based Complexes Incorporating BINAP and π-Extended Diimines: Synthesis, Catalysis and Biological Applications

A series of copper-based photocatalysts of the type Cu(NN)(BINAP)BF(4) were synthesized bearing π-extended diimine ligands. Their behavior in several photocatalytic processes were evaluated and revealed acceptable levels of activity in an SET process, but negligible activity in PCET or ET processes....

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Detalles Bibliográficos
Autores principales: Cruché, Corentin, Gupta, Sayak, Kodanko, Jeremy, Collins, Shawn K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9230762/
https://www.ncbi.nlm.nih.gov/pubmed/35744868
http://dx.doi.org/10.3390/molecules27123745
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author Cruché, Corentin
Gupta, Sayak
Kodanko, Jeremy
Collins, Shawn K.
author_facet Cruché, Corentin
Gupta, Sayak
Kodanko, Jeremy
Collins, Shawn K.
author_sort Cruché, Corentin
collection PubMed
description A series of copper-based photocatalysts of the type Cu(NN)(BINAP)BF(4) were synthesized bearing π-extended diimine ligands. Their behavior in several photocatalytic processes were evaluated and revealed acceptable levels of activity in an SET process, but negligible activity in PCET or ET processes. Suitable activity in ET processes could be restored through modification of the ligand. The BINAP-derived complexes were then evaluated for activity against triple-negative breast cancer cell lines. Controls indicated that copper complexes, and not their ligands, were responsible for activity. Encouraging activity was displayed by a homoleptic complex Cu(dppz)(2)BF(4).
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spelling pubmed-92307622022-06-25 Heteroleptic Copper(I)-Based Complexes Incorporating BINAP and π-Extended Diimines: Synthesis, Catalysis and Biological Applications Cruché, Corentin Gupta, Sayak Kodanko, Jeremy Collins, Shawn K. Molecules Communication A series of copper-based photocatalysts of the type Cu(NN)(BINAP)BF(4) were synthesized bearing π-extended diimine ligands. Their behavior in several photocatalytic processes were evaluated and revealed acceptable levels of activity in an SET process, but negligible activity in PCET or ET processes. Suitable activity in ET processes could be restored through modification of the ligand. The BINAP-derived complexes were then evaluated for activity against triple-negative breast cancer cell lines. Controls indicated that copper complexes, and not their ligands, were responsible for activity. Encouraging activity was displayed by a homoleptic complex Cu(dppz)(2)BF(4). MDPI 2022-06-10 /pmc/articles/PMC9230762/ /pubmed/35744868 http://dx.doi.org/10.3390/molecules27123745 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Communication
Cruché, Corentin
Gupta, Sayak
Kodanko, Jeremy
Collins, Shawn K.
Heteroleptic Copper(I)-Based Complexes Incorporating BINAP and π-Extended Diimines: Synthesis, Catalysis and Biological Applications
title Heteroleptic Copper(I)-Based Complexes Incorporating BINAP and π-Extended Diimines: Synthesis, Catalysis and Biological Applications
title_full Heteroleptic Copper(I)-Based Complexes Incorporating BINAP and π-Extended Diimines: Synthesis, Catalysis and Biological Applications
title_fullStr Heteroleptic Copper(I)-Based Complexes Incorporating BINAP and π-Extended Diimines: Synthesis, Catalysis and Biological Applications
title_full_unstemmed Heteroleptic Copper(I)-Based Complexes Incorporating BINAP and π-Extended Diimines: Synthesis, Catalysis and Biological Applications
title_short Heteroleptic Copper(I)-Based Complexes Incorporating BINAP and π-Extended Diimines: Synthesis, Catalysis and Biological Applications
title_sort heteroleptic copper(i)-based complexes incorporating binap and π-extended diimines: synthesis, catalysis and biological applications
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9230762/
https://www.ncbi.nlm.nih.gov/pubmed/35744868
http://dx.doi.org/10.3390/molecules27123745
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