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Factors Associated with Prolonged RT-PCR SARS-CoV-2 Positive Testing in Patients with Mild and Moderate Forms of COVID-19: A Retrospective Study

Background and objectives: This article aims to evaluate the number of days necessary for patients with mild and moderate forms of COVID-19 to reach undetectable levels of SARS-CoV-2 RNA in the upper respiratory tract specimens. As a secondary objective, we sought to establish a correlation between...

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Autores principales: Motoc, Nicoleta Stefania, Ruta, Victoria-Maria, Man, Milena Adina, Ungur, Rodica Ana, Ciortea, Viorela Mihaela, Irsay, Laszlo, Nicola, Andrea, Valean, Dan, Usatiuc, Lia Oxana, Matei, Ileana Rodica, Borda, Ileana Monica
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9230767/
https://www.ncbi.nlm.nih.gov/pubmed/35743970
http://dx.doi.org/10.3390/medicina58060707
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author Motoc, Nicoleta Stefania
Ruta, Victoria-Maria
Man, Milena Adina
Ungur, Rodica Ana
Ciortea, Viorela Mihaela
Irsay, Laszlo
Nicola, Andrea
Valean, Dan
Usatiuc, Lia Oxana
Matei, Ileana Rodica
Borda, Ileana Monica
author_facet Motoc, Nicoleta Stefania
Ruta, Victoria-Maria
Man, Milena Adina
Ungur, Rodica Ana
Ciortea, Viorela Mihaela
Irsay, Laszlo
Nicola, Andrea
Valean, Dan
Usatiuc, Lia Oxana
Matei, Ileana Rodica
Borda, Ileana Monica
author_sort Motoc, Nicoleta Stefania
collection PubMed
description Background and objectives: This article aims to evaluate the number of days necessary for patients with mild and moderate forms of COVID-19 to reach undetectable levels of SARS-CoV-2 RNA in the upper respiratory tract specimens. As a secondary objective, we sought to establish a correlation between different conditions associated with longer viral load as this could result in a longer period of contagion and infectivity. Materials and Methods: It is a retrospective study. A total of 70 patients with confirmed mild and moderate forms of COVID-19 were enrolled in our study. Results: Number of days with traceable viral load was 25.93 (±6.02) days in patients with mild COVID-19 and 26.97 (±8.30) in moderate form (p = 0.72). Age, male gender, and obesity, along with several chronic conditions (cardiac, liver, renal, and neurological disease), were associated with prolonged positive RT-PCR test from the nasal swab (therefore prolonged viral load). These are in general, risk factors for severe forms of COVID-19. Conclusions: There are several conditions associated with prolonged positive RT-PCR in mild and moderate forms of COVID-19. As to why and what is the significance of it remains to be studied.
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spelling pubmed-92307672022-06-25 Factors Associated with Prolonged RT-PCR SARS-CoV-2 Positive Testing in Patients with Mild and Moderate Forms of COVID-19: A Retrospective Study Motoc, Nicoleta Stefania Ruta, Victoria-Maria Man, Milena Adina Ungur, Rodica Ana Ciortea, Viorela Mihaela Irsay, Laszlo Nicola, Andrea Valean, Dan Usatiuc, Lia Oxana Matei, Ileana Rodica Borda, Ileana Monica Medicina (Kaunas) Article Background and objectives: This article aims to evaluate the number of days necessary for patients with mild and moderate forms of COVID-19 to reach undetectable levels of SARS-CoV-2 RNA in the upper respiratory tract specimens. As a secondary objective, we sought to establish a correlation between different conditions associated with longer viral load as this could result in a longer period of contagion and infectivity. Materials and Methods: It is a retrospective study. A total of 70 patients with confirmed mild and moderate forms of COVID-19 were enrolled in our study. Results: Number of days with traceable viral load was 25.93 (±6.02) days in patients with mild COVID-19 and 26.97 (±8.30) in moderate form (p = 0.72). Age, male gender, and obesity, along with several chronic conditions (cardiac, liver, renal, and neurological disease), were associated with prolonged positive RT-PCR test from the nasal swab (therefore prolonged viral load). These are in general, risk factors for severe forms of COVID-19. Conclusions: There are several conditions associated with prolonged positive RT-PCR in mild and moderate forms of COVID-19. As to why and what is the significance of it remains to be studied. MDPI 2022-05-26 /pmc/articles/PMC9230767/ /pubmed/35743970 http://dx.doi.org/10.3390/medicina58060707 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Motoc, Nicoleta Stefania
Ruta, Victoria-Maria
Man, Milena Adina
Ungur, Rodica Ana
Ciortea, Viorela Mihaela
Irsay, Laszlo
Nicola, Andrea
Valean, Dan
Usatiuc, Lia Oxana
Matei, Ileana Rodica
Borda, Ileana Monica
Factors Associated with Prolonged RT-PCR SARS-CoV-2 Positive Testing in Patients with Mild and Moderate Forms of COVID-19: A Retrospective Study
title Factors Associated with Prolonged RT-PCR SARS-CoV-2 Positive Testing in Patients with Mild and Moderate Forms of COVID-19: A Retrospective Study
title_full Factors Associated with Prolonged RT-PCR SARS-CoV-2 Positive Testing in Patients with Mild and Moderate Forms of COVID-19: A Retrospective Study
title_fullStr Factors Associated with Prolonged RT-PCR SARS-CoV-2 Positive Testing in Patients with Mild and Moderate Forms of COVID-19: A Retrospective Study
title_full_unstemmed Factors Associated with Prolonged RT-PCR SARS-CoV-2 Positive Testing in Patients with Mild and Moderate Forms of COVID-19: A Retrospective Study
title_short Factors Associated with Prolonged RT-PCR SARS-CoV-2 Positive Testing in Patients with Mild and Moderate Forms of COVID-19: A Retrospective Study
title_sort factors associated with prolonged rt-pcr sars-cov-2 positive testing in patients with mild and moderate forms of covid-19: a retrospective study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9230767/
https://www.ncbi.nlm.nih.gov/pubmed/35743970
http://dx.doi.org/10.3390/medicina58060707
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