Cargando…
Factors Associated with Prolonged RT-PCR SARS-CoV-2 Positive Testing in Patients with Mild and Moderate Forms of COVID-19: A Retrospective Study
Background and objectives: This article aims to evaluate the number of days necessary for patients with mild and moderate forms of COVID-19 to reach undetectable levels of SARS-CoV-2 RNA in the upper respiratory tract specimens. As a secondary objective, we sought to establish a correlation between...
Autores principales: | , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9230767/ https://www.ncbi.nlm.nih.gov/pubmed/35743970 http://dx.doi.org/10.3390/medicina58060707 |
_version_ | 1784735149179535360 |
---|---|
author | Motoc, Nicoleta Stefania Ruta, Victoria-Maria Man, Milena Adina Ungur, Rodica Ana Ciortea, Viorela Mihaela Irsay, Laszlo Nicola, Andrea Valean, Dan Usatiuc, Lia Oxana Matei, Ileana Rodica Borda, Ileana Monica |
author_facet | Motoc, Nicoleta Stefania Ruta, Victoria-Maria Man, Milena Adina Ungur, Rodica Ana Ciortea, Viorela Mihaela Irsay, Laszlo Nicola, Andrea Valean, Dan Usatiuc, Lia Oxana Matei, Ileana Rodica Borda, Ileana Monica |
author_sort | Motoc, Nicoleta Stefania |
collection | PubMed |
description | Background and objectives: This article aims to evaluate the number of days necessary for patients with mild and moderate forms of COVID-19 to reach undetectable levels of SARS-CoV-2 RNA in the upper respiratory tract specimens. As a secondary objective, we sought to establish a correlation between different conditions associated with longer viral load as this could result in a longer period of contagion and infectivity. Materials and Methods: It is a retrospective study. A total of 70 patients with confirmed mild and moderate forms of COVID-19 were enrolled in our study. Results: Number of days with traceable viral load was 25.93 (±6.02) days in patients with mild COVID-19 and 26.97 (±8.30) in moderate form (p = 0.72). Age, male gender, and obesity, along with several chronic conditions (cardiac, liver, renal, and neurological disease), were associated with prolonged positive RT-PCR test from the nasal swab (therefore prolonged viral load). These are in general, risk factors for severe forms of COVID-19. Conclusions: There are several conditions associated with prolonged positive RT-PCR in mild and moderate forms of COVID-19. As to why and what is the significance of it remains to be studied. |
format | Online Article Text |
id | pubmed-9230767 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-92307672022-06-25 Factors Associated with Prolonged RT-PCR SARS-CoV-2 Positive Testing in Patients with Mild and Moderate Forms of COVID-19: A Retrospective Study Motoc, Nicoleta Stefania Ruta, Victoria-Maria Man, Milena Adina Ungur, Rodica Ana Ciortea, Viorela Mihaela Irsay, Laszlo Nicola, Andrea Valean, Dan Usatiuc, Lia Oxana Matei, Ileana Rodica Borda, Ileana Monica Medicina (Kaunas) Article Background and objectives: This article aims to evaluate the number of days necessary for patients with mild and moderate forms of COVID-19 to reach undetectable levels of SARS-CoV-2 RNA in the upper respiratory tract specimens. As a secondary objective, we sought to establish a correlation between different conditions associated with longer viral load as this could result in a longer period of contagion and infectivity. Materials and Methods: It is a retrospective study. A total of 70 patients with confirmed mild and moderate forms of COVID-19 were enrolled in our study. Results: Number of days with traceable viral load was 25.93 (±6.02) days in patients with mild COVID-19 and 26.97 (±8.30) in moderate form (p = 0.72). Age, male gender, and obesity, along with several chronic conditions (cardiac, liver, renal, and neurological disease), were associated with prolonged positive RT-PCR test from the nasal swab (therefore prolonged viral load). These are in general, risk factors for severe forms of COVID-19. Conclusions: There are several conditions associated with prolonged positive RT-PCR in mild and moderate forms of COVID-19. As to why and what is the significance of it remains to be studied. MDPI 2022-05-26 /pmc/articles/PMC9230767/ /pubmed/35743970 http://dx.doi.org/10.3390/medicina58060707 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Motoc, Nicoleta Stefania Ruta, Victoria-Maria Man, Milena Adina Ungur, Rodica Ana Ciortea, Viorela Mihaela Irsay, Laszlo Nicola, Andrea Valean, Dan Usatiuc, Lia Oxana Matei, Ileana Rodica Borda, Ileana Monica Factors Associated with Prolonged RT-PCR SARS-CoV-2 Positive Testing in Patients with Mild and Moderate Forms of COVID-19: A Retrospective Study |
title | Factors Associated with Prolonged RT-PCR SARS-CoV-2 Positive Testing in Patients with Mild and Moderate Forms of COVID-19: A Retrospective Study |
title_full | Factors Associated with Prolonged RT-PCR SARS-CoV-2 Positive Testing in Patients with Mild and Moderate Forms of COVID-19: A Retrospective Study |
title_fullStr | Factors Associated with Prolonged RT-PCR SARS-CoV-2 Positive Testing in Patients with Mild and Moderate Forms of COVID-19: A Retrospective Study |
title_full_unstemmed | Factors Associated with Prolonged RT-PCR SARS-CoV-2 Positive Testing in Patients with Mild and Moderate Forms of COVID-19: A Retrospective Study |
title_short | Factors Associated with Prolonged RT-PCR SARS-CoV-2 Positive Testing in Patients with Mild and Moderate Forms of COVID-19: A Retrospective Study |
title_sort | factors associated with prolonged rt-pcr sars-cov-2 positive testing in patients with mild and moderate forms of covid-19: a retrospective study |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9230767/ https://www.ncbi.nlm.nih.gov/pubmed/35743970 http://dx.doi.org/10.3390/medicina58060707 |
work_keys_str_mv | AT motocnicoletastefania factorsassociatedwithprolongedrtpcrsarscov2positivetestinginpatientswithmildandmoderateformsofcovid19aretrospectivestudy AT rutavictoriamaria factorsassociatedwithprolongedrtpcrsarscov2positivetestinginpatientswithmildandmoderateformsofcovid19aretrospectivestudy AT manmilenaadina factorsassociatedwithprolongedrtpcrsarscov2positivetestinginpatientswithmildandmoderateformsofcovid19aretrospectivestudy AT ungurrodicaana factorsassociatedwithprolongedrtpcrsarscov2positivetestinginpatientswithmildandmoderateformsofcovid19aretrospectivestudy AT ciorteaviorelamihaela factorsassociatedwithprolongedrtpcrsarscov2positivetestinginpatientswithmildandmoderateformsofcovid19aretrospectivestudy AT irsaylaszlo factorsassociatedwithprolongedrtpcrsarscov2positivetestinginpatientswithmildandmoderateformsofcovid19aretrospectivestudy AT nicolaandrea factorsassociatedwithprolongedrtpcrsarscov2positivetestinginpatientswithmildandmoderateformsofcovid19aretrospectivestudy AT valeandan factorsassociatedwithprolongedrtpcrsarscov2positivetestinginpatientswithmildandmoderateformsofcovid19aretrospectivestudy AT usatiucliaoxana factorsassociatedwithprolongedrtpcrsarscov2positivetestinginpatientswithmildandmoderateformsofcovid19aretrospectivestudy AT mateiileanarodica factorsassociatedwithprolongedrtpcrsarscov2positivetestinginpatientswithmildandmoderateformsofcovid19aretrospectivestudy AT bordaileanamonica factorsassociatedwithprolongedrtpcrsarscov2positivetestinginpatientswithmildandmoderateformsofcovid19aretrospectivestudy |