Integration of a Physiologically Based Pharmacokinetic and Pharmacodynamic Model for Tegoprazan and Its Metabolite: Application for Predicting Food Effect and Intragastric pH Alterations

A physiologically based pharmacokinetic/pharmacodynamic (PBPK/PD) model for tegoprazan and its major metabolite M1 was developed to predict PK and PD profiles under various scenarios. The PBPK model for tegoprazan and M1 was developed and predicted using the SimCYP(®) simulator and verified using cl...

Descripción completa

Detalles Bibliográficos
Autores principales: Jeong, Hyeon-Cheol, Kim, Min-Gul, Wei, Zhuodu, Lee, Kyeong-Ryoon, Lee, Jaehyeok, Song, Im-Sook, Shin, Kwang-Hee
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9230797/
https://www.ncbi.nlm.nih.gov/pubmed/35745870
http://dx.doi.org/10.3390/pharmaceutics14061298

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9230797/
https://www.ncbi.nlm.nih.gov/pubmed/35745870
http://dx.doi.org/10.3390/pharmaceutics14061298

Ejemplares similares