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Design and Synthesis of C-1 Methoxycarbonyl Derivative of Narciclasine and Its Biological Activity

A 15-step chemoenzymatic total synthesis of C-1 methoxycarbonyl narciclasine (10) was accomplished. The synthesis began with the toluene dioxygenase-mediated dihydroxylation of ortho-dibromobenzene to provide the corresponding cis-dihydrodiol (12) as a single enantiomer. Further key steps included a...

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Detalles Bibliográficos
Autores principales:	Habaz, Lihi, Bedard, Korey, Smith, Mitchell, Du, Liqin, Kornienko, Alexander, Hudlicky, Tomas
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9230822/ https://www.ncbi.nlm.nih.gov/pubmed/35744934 http://dx.doi.org/10.3390/molecules27123809

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