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Mycobacterium bovis Tuberculosis in Two Goat Farms in Multi-Host Ecosystems in Sicily (Italy): Epidemiological, Diagnostic, and Regulatory Considerations

Mycobacterium bovis (M. bovis) is the causative agent of animal tuberculosis (bTB), infecting and causing disease in several animal species. In areas where there are complex interactions between reservoir hosts and susceptible species, the control of this pathogen is a challenge. The authors report...

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Autores principales: Di Marco Lo Presti, Vincenzo, Capucchio, Maria Teresa, Fiasconaro, Michele, Puleio, Roberto, La Mancusa, Francesco, Romeo, Giovanna, Biondo, Carmelinda, Ippolito, Dorotea, Guarda, Franco, Pruiti Ciarello, Flavia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9230833/
https://www.ncbi.nlm.nih.gov/pubmed/35745503
http://dx.doi.org/10.3390/pathogens11060649
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author Di Marco Lo Presti, Vincenzo
Capucchio, Maria Teresa
Fiasconaro, Michele
Puleio, Roberto
La Mancusa, Francesco
Romeo, Giovanna
Biondo, Carmelinda
Ippolito, Dorotea
Guarda, Franco
Pruiti Ciarello, Flavia
author_facet Di Marco Lo Presti, Vincenzo
Capucchio, Maria Teresa
Fiasconaro, Michele
Puleio, Roberto
La Mancusa, Francesco
Romeo, Giovanna
Biondo, Carmelinda
Ippolito, Dorotea
Guarda, Franco
Pruiti Ciarello, Flavia
author_sort Di Marco Lo Presti, Vincenzo
collection PubMed
description Mycobacterium bovis (M. bovis) is the causative agent of animal tuberculosis (bTB), infecting and causing disease in several animal species. In areas where there are complex interactions between reservoir hosts and susceptible species, the control of this pathogen is a challenge. The authors report two outbreaks of goat tuberculosis caused by M. bovis in multi-host ecosystems within two protected natural areas of Sicily, where TB is historically endemic. The first outbreak (Farm A) was identified after the incidental detection at the slaughterhouse of TB-like lesions in goat viscera ready to be disposed. Single intradermal cervical tuberculin test (SICT) was performed in Farm A on 205 goats, resulting positive in 10 (4.9%). After slaughtering, six out of ten animals showed TB-like lesions, from which M. bovis spoligotype SB0841 was isolated. The typing did not reveal any epidemiological connection with the neighboring cattle, suggesting that free-ranging type of management exposed the affected goat livestock or wildlife infected with other strains. The second outbreak (Farm B) was detected in a mixed farm (bovine, caprine, and ovine), where relapsing outbreaks of TB in cattle were registered in the previous years after performing the SICT in cohabiting goats. SICT resulted positive in 6/153 (3.9%), and two animals showed bTB-like lesions. No mycobacteria were cultured, and the final diagnosis of TB was achieved by histopathology and immunohistochemistry. The reported outbreaks highlight the importance of assessing the epidemiological, diagnostic, and regulatory critical issue, which is fundamental to optimizing the strategies of eradicating TB in the endemic multi-host ecosystem described.
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spelling pubmed-92308332022-06-25 Mycobacterium bovis Tuberculosis in Two Goat Farms in Multi-Host Ecosystems in Sicily (Italy): Epidemiological, Diagnostic, and Regulatory Considerations Di Marco Lo Presti, Vincenzo Capucchio, Maria Teresa Fiasconaro, Michele Puleio, Roberto La Mancusa, Francesco Romeo, Giovanna Biondo, Carmelinda Ippolito, Dorotea Guarda, Franco Pruiti Ciarello, Flavia Pathogens Case Report Mycobacterium bovis (M. bovis) is the causative agent of animal tuberculosis (bTB), infecting and causing disease in several animal species. In areas where there are complex interactions between reservoir hosts and susceptible species, the control of this pathogen is a challenge. The authors report two outbreaks of goat tuberculosis caused by M. bovis in multi-host ecosystems within two protected natural areas of Sicily, where TB is historically endemic. The first outbreak (Farm A) was identified after the incidental detection at the slaughterhouse of TB-like lesions in goat viscera ready to be disposed. Single intradermal cervical tuberculin test (SICT) was performed in Farm A on 205 goats, resulting positive in 10 (4.9%). After slaughtering, six out of ten animals showed TB-like lesions, from which M. bovis spoligotype SB0841 was isolated. The typing did not reveal any epidemiological connection with the neighboring cattle, suggesting that free-ranging type of management exposed the affected goat livestock or wildlife infected with other strains. The second outbreak (Farm B) was detected in a mixed farm (bovine, caprine, and ovine), where relapsing outbreaks of TB in cattle were registered in the previous years after performing the SICT in cohabiting goats. SICT resulted positive in 6/153 (3.9%), and two animals showed bTB-like lesions. No mycobacteria were cultured, and the final diagnosis of TB was achieved by histopathology and immunohistochemistry. The reported outbreaks highlight the importance of assessing the epidemiological, diagnostic, and regulatory critical issue, which is fundamental to optimizing the strategies of eradicating TB in the endemic multi-host ecosystem described. MDPI 2022-06-04 /pmc/articles/PMC9230833/ /pubmed/35745503 http://dx.doi.org/10.3390/pathogens11060649 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Case Report
Di Marco Lo Presti, Vincenzo
Capucchio, Maria Teresa
Fiasconaro, Michele
Puleio, Roberto
La Mancusa, Francesco
Romeo, Giovanna
Biondo, Carmelinda
Ippolito, Dorotea
Guarda, Franco
Pruiti Ciarello, Flavia
Mycobacterium bovis Tuberculosis in Two Goat Farms in Multi-Host Ecosystems in Sicily (Italy): Epidemiological, Diagnostic, and Regulatory Considerations
title Mycobacterium bovis Tuberculosis in Two Goat Farms in Multi-Host Ecosystems in Sicily (Italy): Epidemiological, Diagnostic, and Regulatory Considerations
title_full Mycobacterium bovis Tuberculosis in Two Goat Farms in Multi-Host Ecosystems in Sicily (Italy): Epidemiological, Diagnostic, and Regulatory Considerations
title_fullStr Mycobacterium bovis Tuberculosis in Two Goat Farms in Multi-Host Ecosystems in Sicily (Italy): Epidemiological, Diagnostic, and Regulatory Considerations
title_full_unstemmed Mycobacterium bovis Tuberculosis in Two Goat Farms in Multi-Host Ecosystems in Sicily (Italy): Epidemiological, Diagnostic, and Regulatory Considerations
title_short Mycobacterium bovis Tuberculosis in Two Goat Farms in Multi-Host Ecosystems in Sicily (Italy): Epidemiological, Diagnostic, and Regulatory Considerations
title_sort mycobacterium bovis tuberculosis in two goat farms in multi-host ecosystems in sicily (italy): epidemiological, diagnostic, and regulatory considerations
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9230833/
https://www.ncbi.nlm.nih.gov/pubmed/35745503
http://dx.doi.org/10.3390/pathogens11060649
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