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Co-Amorphous Formation of Simvastatin-Ezetimibe: Enhanced Physical Stability, Bioavailability and Cholesterol-Lowering Effects in LDLr−/−Mice

Hypercholesterolemia is one of the independent risk factors for the development of cardiovascular diseases such as atherosclerosis. The treatment of hypercholesterolemia is of great significance to reduce clinical cardiovascular events and patient mortality. Simvastatin (SIM) and ezetimibe (EZE) are...

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Detalles Bibliográficos
Autores principales:	Bahetibieke, Shamuha, Moinuddin, Sakib M., Baiyisaiti, Asiya, Liu, Xiaoang, Zhang, Jie, Liu, Guomin, Shi, Qin, Peng, Ankang, Tao, Jun, Di, Chang, Cai, Ting, Qi, Rong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9230881/ https://www.ncbi.nlm.nih.gov/pubmed/35745830 http://dx.doi.org/10.3390/pharmaceutics14061258

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