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The Possible Effects of Zinc Supplementation on Postpartum Depression and Anemia

Background and Objectives: The effects of postpartum zinc supplementation are still unclear. Our purpose in this study is to investigate the association between Zn supplementation and postpartum depression, defined by an Edinburgh Postnatal Depression Scale (EPDS) score ≥ 9, and the effect on the he...

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Autores principales: Aoki, Chieko, Imai, Kenji, Owaki, Taro, Kobayashi-Nakano, Tomoko, Ushida, Takafumi, Iitani, Yukako, Nakamura, Noriyuki, Kajiyama, Hiroaki, Kotani, Tomomi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9230907/
https://www.ncbi.nlm.nih.gov/pubmed/35743994
http://dx.doi.org/10.3390/medicina58060731
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author Aoki, Chieko
Imai, Kenji
Owaki, Taro
Kobayashi-Nakano, Tomoko
Ushida, Takafumi
Iitani, Yukako
Nakamura, Noriyuki
Kajiyama, Hiroaki
Kotani, Tomomi
author_facet Aoki, Chieko
Imai, Kenji
Owaki, Taro
Kobayashi-Nakano, Tomoko
Ushida, Takafumi
Iitani, Yukako
Nakamura, Noriyuki
Kajiyama, Hiroaki
Kotani, Tomomi
author_sort Aoki, Chieko
collection PubMed
description Background and Objectives: The effects of postpartum zinc supplementation are still unclear. Our purpose in this study is to investigate the association between Zn supplementation and postpartum depression, defined by an Edinburgh Postnatal Depression Scale (EPDS) score ≥ 9, and the effect on the hematological status of postpartum women. Materials and Methods: We first investigated whether zinc supplementation affected the perioperative levels of zinc, hemoglobin, and hematocrit in 197 cases who underwent cesarean section and had postpartum anemia. Next, logistic regression analyses were performed on 148 eligible cases to determine the association between zinc supplementation and postpartum depression. Results: Postpartum zinc supplementation significantly improved the status of maternal blood zinc levels and reduced the risk of developing postpartum depression (adjusted odds ratio: 0.249; 95% confidence interval: 0.062–0.988; p = 0.048). Iron supplementation is a standard and effective strategy for treating anemia; however, the combination of oral iron plus zinc supplementation resulted in slightly significant negative effects on postpartum hemoglobin and hematocrit compared to oral iron supplementation only. Conclusions: Postpartum zinc supplementation causes a significant positive effect on postpartum depression (EPDS score ≥ 9). Zinc supplementation had a negative but transient influence on the hematological status in women with postpartum anemia treated with oral iron supplementation; however, the differences were not clinically significant. Thus, we did not regard it as an adverse effect to be considered, and postpartum zinc supplementation may be viewed as beneficial in postpartum women.
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spelling pubmed-92309072022-06-25 The Possible Effects of Zinc Supplementation on Postpartum Depression and Anemia Aoki, Chieko Imai, Kenji Owaki, Taro Kobayashi-Nakano, Tomoko Ushida, Takafumi Iitani, Yukako Nakamura, Noriyuki Kajiyama, Hiroaki Kotani, Tomomi Medicina (Kaunas) Article Background and Objectives: The effects of postpartum zinc supplementation are still unclear. Our purpose in this study is to investigate the association between Zn supplementation and postpartum depression, defined by an Edinburgh Postnatal Depression Scale (EPDS) score ≥ 9, and the effect on the hematological status of postpartum women. Materials and Methods: We first investigated whether zinc supplementation affected the perioperative levels of zinc, hemoglobin, and hematocrit in 197 cases who underwent cesarean section and had postpartum anemia. Next, logistic regression analyses were performed on 148 eligible cases to determine the association between zinc supplementation and postpartum depression. Results: Postpartum zinc supplementation significantly improved the status of maternal blood zinc levels and reduced the risk of developing postpartum depression (adjusted odds ratio: 0.249; 95% confidence interval: 0.062–0.988; p = 0.048). Iron supplementation is a standard and effective strategy for treating anemia; however, the combination of oral iron plus zinc supplementation resulted in slightly significant negative effects on postpartum hemoglobin and hematocrit compared to oral iron supplementation only. Conclusions: Postpartum zinc supplementation causes a significant positive effect on postpartum depression (EPDS score ≥ 9). Zinc supplementation had a negative but transient influence on the hematological status in women with postpartum anemia treated with oral iron supplementation; however, the differences were not clinically significant. Thus, we did not regard it as an adverse effect to be considered, and postpartum zinc supplementation may be viewed as beneficial in postpartum women. MDPI 2022-05-29 /pmc/articles/PMC9230907/ /pubmed/35743994 http://dx.doi.org/10.3390/medicina58060731 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Aoki, Chieko
Imai, Kenji
Owaki, Taro
Kobayashi-Nakano, Tomoko
Ushida, Takafumi
Iitani, Yukako
Nakamura, Noriyuki
Kajiyama, Hiroaki
Kotani, Tomomi
The Possible Effects of Zinc Supplementation on Postpartum Depression and Anemia
title The Possible Effects of Zinc Supplementation on Postpartum Depression and Anemia
title_full The Possible Effects of Zinc Supplementation on Postpartum Depression and Anemia
title_fullStr The Possible Effects of Zinc Supplementation on Postpartum Depression and Anemia
title_full_unstemmed The Possible Effects of Zinc Supplementation on Postpartum Depression and Anemia
title_short The Possible Effects of Zinc Supplementation on Postpartum Depression and Anemia
title_sort possible effects of zinc supplementation on postpartum depression and anemia
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9230907/
https://www.ncbi.nlm.nih.gov/pubmed/35743994
http://dx.doi.org/10.3390/medicina58060731
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