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State of the Art in Capsule-Based Dry Powder Inhalers: Deagglomeration Techniques and the Consequences for Formulation Aerosolization

Commercially available dry powder inhalers (DPIs) are usually devices in a fixed combination with the intended formulation, and a change in medication by the physician often forces the patient to use a different device, requiring the patient to relearn how to use it, resulting in lower adherence and...

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Autores principales: Groß, Roman, Berkenfeld, Kai, Schulte, Christoph, Ebert, Anselm, Sule, Sunita, Sule, Ameet, Lamprecht, Alf
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9230934/
https://www.ncbi.nlm.nih.gov/pubmed/35745758
http://dx.doi.org/10.3390/pharmaceutics14061185
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author Groß, Roman
Berkenfeld, Kai
Schulte, Christoph
Ebert, Anselm
Sule, Sunita
Sule, Ameet
Lamprecht, Alf
author_facet Groß, Roman
Berkenfeld, Kai
Schulte, Christoph
Ebert, Anselm
Sule, Sunita
Sule, Ameet
Lamprecht, Alf
author_sort Groß, Roman
collection PubMed
description Commercially available dry powder inhalers (DPIs) are usually devices in a fixed combination with the intended formulation, and a change in medication by the physician often forces the patient to use a different device, requiring the patient to relearn how to use it, resulting in lower adherence and inadequate therapy. To investigate whether DPIs can achieve successful outcomes regardless of the formulation and flow rate used, a novel DPI and two commercially available devices were compared in vitro for their deagglomeration behavior for different binary blends and a spray-dried particle formulation. The results demonstrate that the novel device achieved the highest fine particle fraction (FPF) regardless of the formulations tested. In the binary mixtures tested, the highest emitted fraction was obtained by shaking out the powder due to the oscillating motion of the capsule in the novel device during actuation. For DPIs with high intrinsic resistance to airflow, similar FPFs were obtained with the respective DPI and formulation, regardless of the applied flow rate. Additionally, the development and use of binary blends of spray-dried APIs and carrier particles may result in high FPF and overcome disadvantages of spray-dried particles, such as high powder retention in the capsule.
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spelling pubmed-92309342022-06-25 State of the Art in Capsule-Based Dry Powder Inhalers: Deagglomeration Techniques and the Consequences for Formulation Aerosolization Groß, Roman Berkenfeld, Kai Schulte, Christoph Ebert, Anselm Sule, Sunita Sule, Ameet Lamprecht, Alf Pharmaceutics Article Commercially available dry powder inhalers (DPIs) are usually devices in a fixed combination with the intended formulation, and a change in medication by the physician often forces the patient to use a different device, requiring the patient to relearn how to use it, resulting in lower adherence and inadequate therapy. To investigate whether DPIs can achieve successful outcomes regardless of the formulation and flow rate used, a novel DPI and two commercially available devices were compared in vitro for their deagglomeration behavior for different binary blends and a spray-dried particle formulation. The results demonstrate that the novel device achieved the highest fine particle fraction (FPF) regardless of the formulations tested. In the binary mixtures tested, the highest emitted fraction was obtained by shaking out the powder due to the oscillating motion of the capsule in the novel device during actuation. For DPIs with high intrinsic resistance to airflow, similar FPFs were obtained with the respective DPI and formulation, regardless of the applied flow rate. Additionally, the development and use of binary blends of spray-dried APIs and carrier particles may result in high FPF and overcome disadvantages of spray-dried particles, such as high powder retention in the capsule. MDPI 2022-05-31 /pmc/articles/PMC9230934/ /pubmed/35745758 http://dx.doi.org/10.3390/pharmaceutics14061185 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Groß, Roman
Berkenfeld, Kai
Schulte, Christoph
Ebert, Anselm
Sule, Sunita
Sule, Ameet
Lamprecht, Alf
State of the Art in Capsule-Based Dry Powder Inhalers: Deagglomeration Techniques and the Consequences for Formulation Aerosolization
title State of the Art in Capsule-Based Dry Powder Inhalers: Deagglomeration Techniques and the Consequences for Formulation Aerosolization
title_full State of the Art in Capsule-Based Dry Powder Inhalers: Deagglomeration Techniques and the Consequences for Formulation Aerosolization
title_fullStr State of the Art in Capsule-Based Dry Powder Inhalers: Deagglomeration Techniques and the Consequences for Formulation Aerosolization
title_full_unstemmed State of the Art in Capsule-Based Dry Powder Inhalers: Deagglomeration Techniques and the Consequences for Formulation Aerosolization
title_short State of the Art in Capsule-Based Dry Powder Inhalers: Deagglomeration Techniques and the Consequences for Formulation Aerosolization
title_sort state of the art in capsule-based dry powder inhalers: deagglomeration techniques and the consequences for formulation aerosolization
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9230934/
https://www.ncbi.nlm.nih.gov/pubmed/35745758
http://dx.doi.org/10.3390/pharmaceutics14061185
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