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Therapeutic Treatment of 2A Grade Burns with Decellularized Bovine Peritoneum as a Xenograft: Multicenter Randomized Clinical Trial

Background and Objectives: Homogeneous and xenogenic bioengineering structures are actively used as wound coatings in treatment of burns and have already shown their effectiveness. Nevertheless, the disadvantage of such dressings is their high cost. This issue is particularly challenging for develop...

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Autores principales: Tuleubayev, Berik, Ogay, Vyacheslav, Anapiya, Baurzhan, Zhylkibayev, Assylbek, Saginova, Dina, Koshanova, Amina, Kurmangaliyev, Yerkin-Dauir, Tezekbayev, Kanat, Bikonurov, Nurzhan, Abugaliyev, Kabylbek
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9230981/
https://www.ncbi.nlm.nih.gov/pubmed/35744082
http://dx.doi.org/10.3390/medicina58060819
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author Tuleubayev, Berik
Ogay, Vyacheslav
Anapiya, Baurzhan
Zhylkibayev, Assylbek
Saginova, Dina
Koshanova, Amina
Kurmangaliyev, Yerkin-Dauir
Tezekbayev, Kanat
Bikonurov, Nurzhan
Abugaliyev, Kabylbek
author_facet Tuleubayev, Berik
Ogay, Vyacheslav
Anapiya, Baurzhan
Zhylkibayev, Assylbek
Saginova, Dina
Koshanova, Amina
Kurmangaliyev, Yerkin-Dauir
Tezekbayev, Kanat
Bikonurov, Nurzhan
Abugaliyev, Kabylbek
author_sort Tuleubayev, Berik
collection PubMed
description Background and Objectives: Homogeneous and xenogenic bioengineering structures are actively used as wound coatings in treatment of burns and have already shown their effectiveness. Nevertheless, the disadvantage of such dressings is their high cost. This issue is particularly challenging for developing countries in which the incidence of burns is the highest one. With such needs taken into account, the research team developed and clinically tested a new wound coating based on decellularized bovine peritoneum (DBP). Materials and Methods: A multicenter randomized clinical trial was conducted to evaluate DBP. The following variables were considered in the research study: the number of inpatient days, the number of dressing changes, the level of pain experienced during dressing changes, and the condition of wounds at the time of the follow-up examination. Results: The research involved 68 participants. It was found that the patients who were treated with a DBP experienced less pain with less changes of dressings. However, the number of inpatient days and wound healing failed to demonstrate statistically significant difference compared to the control group. Conclusions: In the given research, DBP showed efficacy in improving patients’ quality of life by reducing pain and the number of dressings’ changes. However, when comparing this research study with the studies of other animal-derived wound coverings, there were a number of differences and limitations in the parameters. Thus, the results requires further study for a greater comparability of data. Given the above, we expect that DBP will become an inexpensive and effective treatment for burns in developing countries.
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spelling pubmed-92309812022-06-25 Therapeutic Treatment of 2A Grade Burns with Decellularized Bovine Peritoneum as a Xenograft: Multicenter Randomized Clinical Trial Tuleubayev, Berik Ogay, Vyacheslav Anapiya, Baurzhan Zhylkibayev, Assylbek Saginova, Dina Koshanova, Amina Kurmangaliyev, Yerkin-Dauir Tezekbayev, Kanat Bikonurov, Nurzhan Abugaliyev, Kabylbek Medicina (Kaunas) Article Background and Objectives: Homogeneous and xenogenic bioengineering structures are actively used as wound coatings in treatment of burns and have already shown their effectiveness. Nevertheless, the disadvantage of such dressings is their high cost. This issue is particularly challenging for developing countries in which the incidence of burns is the highest one. With such needs taken into account, the research team developed and clinically tested a new wound coating based on decellularized bovine peritoneum (DBP). Materials and Methods: A multicenter randomized clinical trial was conducted to evaluate DBP. The following variables were considered in the research study: the number of inpatient days, the number of dressing changes, the level of pain experienced during dressing changes, and the condition of wounds at the time of the follow-up examination. Results: The research involved 68 participants. It was found that the patients who were treated with a DBP experienced less pain with less changes of dressings. However, the number of inpatient days and wound healing failed to demonstrate statistically significant difference compared to the control group. Conclusions: In the given research, DBP showed efficacy in improving patients’ quality of life by reducing pain and the number of dressings’ changes. However, when comparing this research study with the studies of other animal-derived wound coverings, there were a number of differences and limitations in the parameters. Thus, the results requires further study for a greater comparability of data. Given the above, we expect that DBP will become an inexpensive and effective treatment for burns in developing countries. MDPI 2022-06-17 /pmc/articles/PMC9230981/ /pubmed/35744082 http://dx.doi.org/10.3390/medicina58060819 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Tuleubayev, Berik
Ogay, Vyacheslav
Anapiya, Baurzhan
Zhylkibayev, Assylbek
Saginova, Dina
Koshanova, Amina
Kurmangaliyev, Yerkin-Dauir
Tezekbayev, Kanat
Bikonurov, Nurzhan
Abugaliyev, Kabylbek
Therapeutic Treatment of 2A Grade Burns with Decellularized Bovine Peritoneum as a Xenograft: Multicenter Randomized Clinical Trial
title Therapeutic Treatment of 2A Grade Burns with Decellularized Bovine Peritoneum as a Xenograft: Multicenter Randomized Clinical Trial
title_full Therapeutic Treatment of 2A Grade Burns with Decellularized Bovine Peritoneum as a Xenograft: Multicenter Randomized Clinical Trial
title_fullStr Therapeutic Treatment of 2A Grade Burns with Decellularized Bovine Peritoneum as a Xenograft: Multicenter Randomized Clinical Trial
title_full_unstemmed Therapeutic Treatment of 2A Grade Burns with Decellularized Bovine Peritoneum as a Xenograft: Multicenter Randomized Clinical Trial
title_short Therapeutic Treatment of 2A Grade Burns with Decellularized Bovine Peritoneum as a Xenograft: Multicenter Randomized Clinical Trial
title_sort therapeutic treatment of 2a grade burns with decellularized bovine peritoneum as a xenograft: multicenter randomized clinical trial
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9230981/
https://www.ncbi.nlm.nih.gov/pubmed/35744082
http://dx.doi.org/10.3390/medicina58060819
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