Eco-Friendly Synthesis of PEtOz-PA: A Promising Polymer for the Formulation of Curcumin-Loaded Micelles

The need to develop alternative methods or to use “green” solvents constitutes an essential strategy under the emerging field of green chemistry, particularly in the development of new synthetic strategies in the field of pharmaceutic industry. We report an eco-friendly method of synthesis of poly(2...

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Autores principales: Nardi, Monica, Sarubbi, Emiliana, Somavarapu, Satyanarayana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9231041/
https://www.ncbi.nlm.nih.gov/pubmed/35744914
http://dx.doi.org/10.3390/molecules27123788
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author Nardi, Monica
Sarubbi, Emiliana
Somavarapu, Satyanarayana
author_facet Nardi, Monica
Sarubbi, Emiliana
Somavarapu, Satyanarayana
author_sort Nardi, Monica
collection PubMed
description The need to develop alternative methods or to use “green” solvents constitutes an essential strategy under the emerging field of green chemistry, particularly in the development of new synthetic strategies in the field of pharmaceutic industry. We report an eco-friendly method of synthesis of poly(2-ethyl-2-oxazoline)-palmitoylate (PEtOz-PA) using Er(OTf)(3) as Lewis’s acid catalyst in 2-MeTHF. The novel biomolecule derivative was characterized to confirm palmitoyl group substitution and employed for the formulation, characterization, and antioxidant activity evaluation of curcumin-loaded polymeric micelles.
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spelling pubmed-92310412022-06-25 Eco-Friendly Synthesis of PEtOz-PA: A Promising Polymer for the Formulation of Curcumin-Loaded Micelles Nardi, Monica Sarubbi, Emiliana Somavarapu, Satyanarayana Molecules Article The need to develop alternative methods or to use “green” solvents constitutes an essential strategy under the emerging field of green chemistry, particularly in the development of new synthetic strategies in the field of pharmaceutic industry. We report an eco-friendly method of synthesis of poly(2-ethyl-2-oxazoline)-palmitoylate (PEtOz-PA) using Er(OTf)(3) as Lewis’s acid catalyst in 2-MeTHF. The novel biomolecule derivative was characterized to confirm palmitoyl group substitution and employed for the formulation, characterization, and antioxidant activity evaluation of curcumin-loaded polymeric micelles. MDPI 2022-06-12 /pmc/articles/PMC9231041/ /pubmed/35744914 http://dx.doi.org/10.3390/molecules27123788 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Nardi, Monica
Sarubbi, Emiliana
Somavarapu, Satyanarayana
Eco-Friendly Synthesis of PEtOz-PA: A Promising Polymer for the Formulation of Curcumin-Loaded Micelles
title Eco-Friendly Synthesis of PEtOz-PA: A Promising Polymer for the Formulation of Curcumin-Loaded Micelles
title_full Eco-Friendly Synthesis of PEtOz-PA: A Promising Polymer for the Formulation of Curcumin-Loaded Micelles
title_fullStr Eco-Friendly Synthesis of PEtOz-PA: A Promising Polymer for the Formulation of Curcumin-Loaded Micelles
title_full_unstemmed Eco-Friendly Synthesis of PEtOz-PA: A Promising Polymer for the Formulation of Curcumin-Loaded Micelles
title_short Eco-Friendly Synthesis of PEtOz-PA: A Promising Polymer for the Formulation of Curcumin-Loaded Micelles
title_sort eco-friendly synthesis of petoz-pa: a promising polymer for the formulation of curcumin-loaded micelles
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9231041/
https://www.ncbi.nlm.nih.gov/pubmed/35744914
http://dx.doi.org/10.3390/molecules27123788
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AT somavarapusatyanarayana ecofriendlysynthesisofpetozpaapromisingpolymerfortheformulationofcurcuminloadedmicelles

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