Cargando…
Safety of Antibiotics in Hospitalized Children in Romania: A Prospective Observational Study
Antibiotics are among the most prescribed drugs in pediatric inpatients and are frequently associated with adverse drug reactions (ADRs) in children. This study aimed to assess the frequency and type of ADRs related to the use of antibiotics in pediatric inpatients through a prospective observationa...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9231061/ https://www.ncbi.nlm.nih.gov/pubmed/35745632 http://dx.doi.org/10.3390/ph15060713 |
_version_ | 1784735236260626432 |
---|---|
author | Bulik, Noémi-Beátrix Farcaș, Andreea Bucșa, Camelia Iaru, Irina Oniga, Ovidiu |
author_facet | Bulik, Noémi-Beátrix Farcaș, Andreea Bucșa, Camelia Iaru, Irina Oniga, Ovidiu |
author_sort | Bulik, Noémi-Beátrix |
collection | PubMed |
description | Antibiotics are among the most prescribed drugs in pediatric inpatients and are frequently associated with adverse drug reactions (ADRs) in children. This study aimed to assess the frequency and type of ADRs related to the use of antibiotics in pediatric inpatients through a prospective observational study, conducted over 6 months, covering the winter and spring seasons when the incidence of infections peaks in Romania. ADRs were evaluated for causality, avoidability and severity. Among the 266 included children, 25 (9.4%) experienced 30 ADRs. ADR frequency tended to be higher in ≤2-year-olds (13 of 25, 52.0%) than in other age categories. Gastrointestinal and hematological ADRs were most frequently observed. Diarrhea was the most common ADR associated with antibiotics (8 of 30, 26.7%). Ceftriaxone (16 of 30, 53.3%), cefuroxime, ceftazidime and azithromycin (3 of 30, 10.0% each) were most commonly responsible for ADRs. After causality assessment, 2 (6.7%) ADRs were considered definite, 12 (40.0%) probable and 16 (53.3%) possible. One ADR was classified as definitely avoidable and one as possibly avoidable. Seven children required treatment for ADRs. Antibiotic treatment was discontinued in 4 children. Antibiotics frequently caused ADRs in ≤ 2-year-olds and were commonly associated with gastrointestinal symptoms. Close monitoring of antibiotic-associated ADRs remains important in the pediatric population. |
format | Online Article Text |
id | pubmed-9231061 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-92310612022-06-25 Safety of Antibiotics in Hospitalized Children in Romania: A Prospective Observational Study Bulik, Noémi-Beátrix Farcaș, Andreea Bucșa, Camelia Iaru, Irina Oniga, Ovidiu Pharmaceuticals (Basel) Article Antibiotics are among the most prescribed drugs in pediatric inpatients and are frequently associated with adverse drug reactions (ADRs) in children. This study aimed to assess the frequency and type of ADRs related to the use of antibiotics in pediatric inpatients through a prospective observational study, conducted over 6 months, covering the winter and spring seasons when the incidence of infections peaks in Romania. ADRs were evaluated for causality, avoidability and severity. Among the 266 included children, 25 (9.4%) experienced 30 ADRs. ADR frequency tended to be higher in ≤2-year-olds (13 of 25, 52.0%) than in other age categories. Gastrointestinal and hematological ADRs were most frequently observed. Diarrhea was the most common ADR associated with antibiotics (8 of 30, 26.7%). Ceftriaxone (16 of 30, 53.3%), cefuroxime, ceftazidime and azithromycin (3 of 30, 10.0% each) were most commonly responsible for ADRs. After causality assessment, 2 (6.7%) ADRs were considered definite, 12 (40.0%) probable and 16 (53.3%) possible. One ADR was classified as definitely avoidable and one as possibly avoidable. Seven children required treatment for ADRs. Antibiotic treatment was discontinued in 4 children. Antibiotics frequently caused ADRs in ≤ 2-year-olds and were commonly associated with gastrointestinal symptoms. Close monitoring of antibiotic-associated ADRs remains important in the pediatric population. MDPI 2022-06-03 /pmc/articles/PMC9231061/ /pubmed/35745632 http://dx.doi.org/10.3390/ph15060713 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Bulik, Noémi-Beátrix Farcaș, Andreea Bucșa, Camelia Iaru, Irina Oniga, Ovidiu Safety of Antibiotics in Hospitalized Children in Romania: A Prospective Observational Study |
title | Safety of Antibiotics in Hospitalized Children in Romania: A Prospective Observational Study |
title_full | Safety of Antibiotics in Hospitalized Children in Romania: A Prospective Observational Study |
title_fullStr | Safety of Antibiotics in Hospitalized Children in Romania: A Prospective Observational Study |
title_full_unstemmed | Safety of Antibiotics in Hospitalized Children in Romania: A Prospective Observational Study |
title_short | Safety of Antibiotics in Hospitalized Children in Romania: A Prospective Observational Study |
title_sort | safety of antibiotics in hospitalized children in romania: a prospective observational study |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9231061/ https://www.ncbi.nlm.nih.gov/pubmed/35745632 http://dx.doi.org/10.3390/ph15060713 |
work_keys_str_mv | AT buliknoemibeatrix safetyofantibioticsinhospitalizedchildreninromaniaaprospectiveobservationalstudy AT farcasandreea safetyofantibioticsinhospitalizedchildreninromaniaaprospectiveobservationalstudy AT bucsacamelia safetyofantibioticsinhospitalizedchildreninromaniaaprospectiveobservationalstudy AT iaruirina safetyofantibioticsinhospitalizedchildreninromaniaaprospectiveobservationalstudy AT onigaovidiu safetyofantibioticsinhospitalizedchildreninromaniaaprospectiveobservationalstudy |