Cargando…

Safety of Antibiotics in Hospitalized Children in Romania: A Prospective Observational Study

Antibiotics are among the most prescribed drugs in pediatric inpatients and are frequently associated with adverse drug reactions (ADRs) in children. This study aimed to assess the frequency and type of ADRs related to the use of antibiotics in pediatric inpatients through a prospective observationa...

Descripción completa

Detalles Bibliográficos
Autores principales: Bulik, Noémi-Beátrix, Farcaș, Andreea, Bucșa, Camelia, Iaru, Irina, Oniga, Ovidiu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9231061/
https://www.ncbi.nlm.nih.gov/pubmed/35745632
http://dx.doi.org/10.3390/ph15060713
_version_ 1784735236260626432
author Bulik, Noémi-Beátrix
Farcaș, Andreea
Bucșa, Camelia
Iaru, Irina
Oniga, Ovidiu
author_facet Bulik, Noémi-Beátrix
Farcaș, Andreea
Bucșa, Camelia
Iaru, Irina
Oniga, Ovidiu
author_sort Bulik, Noémi-Beátrix
collection PubMed
description Antibiotics are among the most prescribed drugs in pediatric inpatients and are frequently associated with adverse drug reactions (ADRs) in children. This study aimed to assess the frequency and type of ADRs related to the use of antibiotics in pediatric inpatients through a prospective observational study, conducted over 6 months, covering the winter and spring seasons when the incidence of infections peaks in Romania. ADRs were evaluated for causality, avoidability and severity. Among the 266 included children, 25 (9.4%) experienced 30 ADRs. ADR frequency tended to be higher in ≤2-year-olds (13 of 25, 52.0%) than in other age categories. Gastrointestinal and hematological ADRs were most frequently observed. Diarrhea was the most common ADR associated with antibiotics (8 of 30, 26.7%). Ceftriaxone (16 of 30, 53.3%), cefuroxime, ceftazidime and azithromycin (3 of 30, 10.0% each) were most commonly responsible for ADRs. After causality assessment, 2 (6.7%) ADRs were considered definite, 12 (40.0%) probable and 16 (53.3%) possible. One ADR was classified as definitely avoidable and one as possibly avoidable. Seven children required treatment for ADRs. Antibiotic treatment was discontinued in 4 children. Antibiotics frequently caused ADRs in ≤ 2-year-olds and were commonly associated with gastrointestinal symptoms. Close monitoring of antibiotic-associated ADRs remains important in the pediatric population.
format Online
Article
Text
id pubmed-9231061
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-92310612022-06-25 Safety of Antibiotics in Hospitalized Children in Romania: A Prospective Observational Study Bulik, Noémi-Beátrix Farcaș, Andreea Bucșa, Camelia Iaru, Irina Oniga, Ovidiu Pharmaceuticals (Basel) Article Antibiotics are among the most prescribed drugs in pediatric inpatients and are frequently associated with adverse drug reactions (ADRs) in children. This study aimed to assess the frequency and type of ADRs related to the use of antibiotics in pediatric inpatients through a prospective observational study, conducted over 6 months, covering the winter and spring seasons when the incidence of infections peaks in Romania. ADRs were evaluated for causality, avoidability and severity. Among the 266 included children, 25 (9.4%) experienced 30 ADRs. ADR frequency tended to be higher in ≤2-year-olds (13 of 25, 52.0%) than in other age categories. Gastrointestinal and hematological ADRs were most frequently observed. Diarrhea was the most common ADR associated with antibiotics (8 of 30, 26.7%). Ceftriaxone (16 of 30, 53.3%), cefuroxime, ceftazidime and azithromycin (3 of 30, 10.0% each) were most commonly responsible for ADRs. After causality assessment, 2 (6.7%) ADRs were considered definite, 12 (40.0%) probable and 16 (53.3%) possible. One ADR was classified as definitely avoidable and one as possibly avoidable. Seven children required treatment for ADRs. Antibiotic treatment was discontinued in 4 children. Antibiotics frequently caused ADRs in ≤ 2-year-olds and were commonly associated with gastrointestinal symptoms. Close monitoring of antibiotic-associated ADRs remains important in the pediatric population. MDPI 2022-06-03 /pmc/articles/PMC9231061/ /pubmed/35745632 http://dx.doi.org/10.3390/ph15060713 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Bulik, Noémi-Beátrix
Farcaș, Andreea
Bucșa, Camelia
Iaru, Irina
Oniga, Ovidiu
Safety of Antibiotics in Hospitalized Children in Romania: A Prospective Observational Study
title Safety of Antibiotics in Hospitalized Children in Romania: A Prospective Observational Study
title_full Safety of Antibiotics in Hospitalized Children in Romania: A Prospective Observational Study
title_fullStr Safety of Antibiotics in Hospitalized Children in Romania: A Prospective Observational Study
title_full_unstemmed Safety of Antibiotics in Hospitalized Children in Romania: A Prospective Observational Study
title_short Safety of Antibiotics in Hospitalized Children in Romania: A Prospective Observational Study
title_sort safety of antibiotics in hospitalized children in romania: a prospective observational study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9231061/
https://www.ncbi.nlm.nih.gov/pubmed/35745632
http://dx.doi.org/10.3390/ph15060713
work_keys_str_mv AT buliknoemibeatrix safetyofantibioticsinhospitalizedchildreninromaniaaprospectiveobservationalstudy
AT farcasandreea safetyofantibioticsinhospitalizedchildreninromaniaaprospectiveobservationalstudy
AT bucsacamelia safetyofantibioticsinhospitalizedchildreninromaniaaprospectiveobservationalstudy
AT iaruirina safetyofantibioticsinhospitalizedchildreninromaniaaprospectiveobservationalstudy
AT onigaovidiu safetyofantibioticsinhospitalizedchildreninromaniaaprospectiveobservationalstudy