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Very Low Alcohol Consumption Is Associated with Lower Prevalence of Cirrhosis and Hepatocellular Carcinoma in Patients with Non-Alcoholic Fatty Liver Disease

The role of moderate alcohol consumption in the evolution of NAFLD is still debated. The aim of this study is to evaluate the impact of current and lifelong alcohol consumption in patients with NAFLD. From 2015 to 2020, we enrolled 276 consecutive patients fulfilling criteria of NAFLD (alcohol consu...

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Autores principales: Ferri, Silvia, Stefanini, Bernardo, Mulazzani, Lorenzo, Alvisi, Margherita, Tovoli, Francesco, Leoni, Simona, Muratori, Luca, Lotti, Tommaso, Granito, Alessandro, Bolondi, Luigi, Piscaglia, Fabio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9231078/
https://www.ncbi.nlm.nih.gov/pubmed/35745223
http://dx.doi.org/10.3390/nu14122493
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author Ferri, Silvia
Stefanini, Bernardo
Mulazzani, Lorenzo
Alvisi, Margherita
Tovoli, Francesco
Leoni, Simona
Muratori, Luca
Lotti, Tommaso
Granito, Alessandro
Bolondi, Luigi
Piscaglia, Fabio
author_facet Ferri, Silvia
Stefanini, Bernardo
Mulazzani, Lorenzo
Alvisi, Margherita
Tovoli, Francesco
Leoni, Simona
Muratori, Luca
Lotti, Tommaso
Granito, Alessandro
Bolondi, Luigi
Piscaglia, Fabio
author_sort Ferri, Silvia
collection PubMed
description The role of moderate alcohol consumption in the evolution of NAFLD is still debated. The aim of this study is to evaluate the impact of current and lifelong alcohol consumption in patients with NAFLD. From 2015 to 2020, we enrolled 276 consecutive patients fulfilling criteria of NAFLD (alcohol consumption up to 140 g/week for women and 210 g/week for men). According to their current alcohol intake per week, patients were divided in: abstainers, very low consumers (C1: <70 g/week) and moderate consumers (C2). We created a new tool, called LACU (Lifetime Alcohol Consuming Unit) to estimate the alcohol exposure across lifetime: 1 LACU was defined as 7 alcohol units per week for 1 drinking year. Patients were divided into lifelong abstainers and consumers and the latter furtherly divided into quartiles: Q1-Q4. Stratification according to alcohol intake, both current and cumulative as estimated by LACU, showed that very low consumers (C1 and Q1-Q3) displayed lower frequency of cirrhosis and hepatocellular carcinoma compared to abstainers and moderate consumers (C2 and Q4). We can speculate that up to one glass of wine daily in the context of a Mediterranean diet may be a long-term useful approach in selected NAFLD patients.
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spelling pubmed-92310782022-06-25 Very Low Alcohol Consumption Is Associated with Lower Prevalence of Cirrhosis and Hepatocellular Carcinoma in Patients with Non-Alcoholic Fatty Liver Disease Ferri, Silvia Stefanini, Bernardo Mulazzani, Lorenzo Alvisi, Margherita Tovoli, Francesco Leoni, Simona Muratori, Luca Lotti, Tommaso Granito, Alessandro Bolondi, Luigi Piscaglia, Fabio Nutrients Article The role of moderate alcohol consumption in the evolution of NAFLD is still debated. The aim of this study is to evaluate the impact of current and lifelong alcohol consumption in patients with NAFLD. From 2015 to 2020, we enrolled 276 consecutive patients fulfilling criteria of NAFLD (alcohol consumption up to 140 g/week for women and 210 g/week for men). According to their current alcohol intake per week, patients were divided in: abstainers, very low consumers (C1: <70 g/week) and moderate consumers (C2). We created a new tool, called LACU (Lifetime Alcohol Consuming Unit) to estimate the alcohol exposure across lifetime: 1 LACU was defined as 7 alcohol units per week for 1 drinking year. Patients were divided into lifelong abstainers and consumers and the latter furtherly divided into quartiles: Q1-Q4. Stratification according to alcohol intake, both current and cumulative as estimated by LACU, showed that very low consumers (C1 and Q1-Q3) displayed lower frequency of cirrhosis and hepatocellular carcinoma compared to abstainers and moderate consumers (C2 and Q4). We can speculate that up to one glass of wine daily in the context of a Mediterranean diet may be a long-term useful approach in selected NAFLD patients. MDPI 2022-06-16 /pmc/articles/PMC9231078/ /pubmed/35745223 http://dx.doi.org/10.3390/nu14122493 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Ferri, Silvia
Stefanini, Bernardo
Mulazzani, Lorenzo
Alvisi, Margherita
Tovoli, Francesco
Leoni, Simona
Muratori, Luca
Lotti, Tommaso
Granito, Alessandro
Bolondi, Luigi
Piscaglia, Fabio
Very Low Alcohol Consumption Is Associated with Lower Prevalence of Cirrhosis and Hepatocellular Carcinoma in Patients with Non-Alcoholic Fatty Liver Disease
title Very Low Alcohol Consumption Is Associated with Lower Prevalence of Cirrhosis and Hepatocellular Carcinoma in Patients with Non-Alcoholic Fatty Liver Disease
title_full Very Low Alcohol Consumption Is Associated with Lower Prevalence of Cirrhosis and Hepatocellular Carcinoma in Patients with Non-Alcoholic Fatty Liver Disease
title_fullStr Very Low Alcohol Consumption Is Associated with Lower Prevalence of Cirrhosis and Hepatocellular Carcinoma in Patients with Non-Alcoholic Fatty Liver Disease
title_full_unstemmed Very Low Alcohol Consumption Is Associated with Lower Prevalence of Cirrhosis and Hepatocellular Carcinoma in Patients with Non-Alcoholic Fatty Liver Disease
title_short Very Low Alcohol Consumption Is Associated with Lower Prevalence of Cirrhosis and Hepatocellular Carcinoma in Patients with Non-Alcoholic Fatty Liver Disease
title_sort very low alcohol consumption is associated with lower prevalence of cirrhosis and hepatocellular carcinoma in patients with non-alcoholic fatty liver disease
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9231078/
https://www.ncbi.nlm.nih.gov/pubmed/35745223
http://dx.doi.org/10.3390/nu14122493
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