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Monoterpenoid Glycosides from the Leaves of Ligustrum robustum and Their Bioactivities

The leaves of Ligustrum robustum have been applied as Ku-Ding-Cha, a functional tea to clear heat, remove toxins, and treat obesity and diabetes, in Southwest China. The phytochemical research on the leaves of L. robustum led to the isolation and identification of eight new monoterpenoid glycosides...

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Detalles Bibliográficos
Autores principales: Lu, Shi-Hui, Huang, Jing, Zuo, Hao-Jiang, Zhou, Zhong-Bo, Yang, Cai-Yan, Huang, Zu-Liang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9231160/
https://www.ncbi.nlm.nih.gov/pubmed/35744841
http://dx.doi.org/10.3390/molecules27123709
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author Lu, Shi-Hui
Huang, Jing
Zuo, Hao-Jiang
Zhou, Zhong-Bo
Yang, Cai-Yan
Huang, Zu-Liang
author_facet Lu, Shi-Hui
Huang, Jing
Zuo, Hao-Jiang
Zhou, Zhong-Bo
Yang, Cai-Yan
Huang, Zu-Liang
author_sort Lu, Shi-Hui
collection PubMed
description The leaves of Ligustrum robustum have been applied as Ku-Ding-Cha, a functional tea to clear heat, remove toxins, and treat obesity and diabetes, in Southwest China. The phytochemical research on the leaves of L. robustum led to the isolation and identification of eight new monoterpenoid glycosides (1–8) and three known monoterpenoid glycosides (9–11). Compounds 1–11 were tested for the inhibitory activities on fatty acid synthase (FAS), α-glucosidase, α-amylase, and the antioxidant effects. Compound 2 showed stronger FAS inhibitory activity (IC(50): 2.36 ± 0.10 μM) than the positive control orlistat (IC(50): 4.46 ± 0.13 μM), while compounds 1, 2, 5 and 11 displayed more potent ABTS radical scavenging activity (IC(50): 6.91 ± 0.10~9.41 ± 0.22 μM) than the positive control L-(+)-ascorbic acid (IC(50): 10.06 ± 0.19 μM). This study provided a theoretical basis for the leaves of L. robustum as a functional tea to treat obesity.
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spelling pubmed-92311602022-06-25 Monoterpenoid Glycosides from the Leaves of Ligustrum robustum and Their Bioactivities Lu, Shi-Hui Huang, Jing Zuo, Hao-Jiang Zhou, Zhong-Bo Yang, Cai-Yan Huang, Zu-Liang Molecules Article The leaves of Ligustrum robustum have been applied as Ku-Ding-Cha, a functional tea to clear heat, remove toxins, and treat obesity and diabetes, in Southwest China. The phytochemical research on the leaves of L. robustum led to the isolation and identification of eight new monoterpenoid glycosides (1–8) and three known monoterpenoid glycosides (9–11). Compounds 1–11 were tested for the inhibitory activities on fatty acid synthase (FAS), α-glucosidase, α-amylase, and the antioxidant effects. Compound 2 showed stronger FAS inhibitory activity (IC(50): 2.36 ± 0.10 μM) than the positive control orlistat (IC(50): 4.46 ± 0.13 μM), while compounds 1, 2, 5 and 11 displayed more potent ABTS radical scavenging activity (IC(50): 6.91 ± 0.10~9.41 ± 0.22 μM) than the positive control L-(+)-ascorbic acid (IC(50): 10.06 ± 0.19 μM). This study provided a theoretical basis for the leaves of L. robustum as a functional tea to treat obesity. MDPI 2022-06-09 /pmc/articles/PMC9231160/ /pubmed/35744841 http://dx.doi.org/10.3390/molecules27123709 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Lu, Shi-Hui
Huang, Jing
Zuo, Hao-Jiang
Zhou, Zhong-Bo
Yang, Cai-Yan
Huang, Zu-Liang
Monoterpenoid Glycosides from the Leaves of Ligustrum robustum and Their Bioactivities
title Monoterpenoid Glycosides from the Leaves of Ligustrum robustum and Their Bioactivities
title_full Monoterpenoid Glycosides from the Leaves of Ligustrum robustum and Their Bioactivities
title_fullStr Monoterpenoid Glycosides from the Leaves of Ligustrum robustum and Their Bioactivities
title_full_unstemmed Monoterpenoid Glycosides from the Leaves of Ligustrum robustum and Their Bioactivities
title_short Monoterpenoid Glycosides from the Leaves of Ligustrum robustum and Their Bioactivities
title_sort monoterpenoid glycosides from the leaves of ligustrum robustum and their bioactivities
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9231160/
https://www.ncbi.nlm.nih.gov/pubmed/35744841
http://dx.doi.org/10.3390/molecules27123709
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