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Effect of Ylang-Ylang (Cananga odorata Hook. F. & Thomson) Essential Oil on Acute Inflammatory Response In Vitro and In Vivo
The aim of this study is to evaluate the phytochemical profile, oral acute toxicity, and the effect of ylang-ylang (Cananga odorata Hook. F. & Thomson) essential oil (YEO) on acute inflammation. YEO was analyzed by gas chromatography/mass spectrometry. For in vitro tests, YEO was assessed using...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9231162/ https://www.ncbi.nlm.nih.gov/pubmed/35744789 http://dx.doi.org/10.3390/molecules27123666 |
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author | de Freitas Junior, Robson Araújo Lossavaro, Paloma Kênia de Moraes Berenguel Kassuya, Cândida Aparecida Leite Paredes-Gamero, Edgar Julian Farias Júnior, Nelson Carvalho Souza, Maria Inês Lenz Silva-Comar, Francielli Maria de Souza Cuman, Roberto Kenji Nakamura Silva, Denise Brentan Toffoli-Kadri, Mônica Cristina Silva-Filho, Saulo Euclides |
author_facet | de Freitas Junior, Robson Araújo Lossavaro, Paloma Kênia de Moraes Berenguel Kassuya, Cândida Aparecida Leite Paredes-Gamero, Edgar Julian Farias Júnior, Nelson Carvalho Souza, Maria Inês Lenz Silva-Comar, Francielli Maria de Souza Cuman, Roberto Kenji Nakamura Silva, Denise Brentan Toffoli-Kadri, Mônica Cristina Silva-Filho, Saulo Euclides |
author_sort | de Freitas Junior, Robson Araújo |
collection | PubMed |
description | The aim of this study is to evaluate the phytochemical profile, oral acute toxicity, and the effect of ylang-ylang (Cananga odorata Hook. F. & Thomson) essential oil (YEO) on acute inflammation. YEO was analyzed by gas chromatography/mass spectrometry. For in vitro tests, YEO was assessed using cytotoxicity, neutrophil chemotaxis induced by N-formyl methionyl leucyl phenylalanine (fMLP), and phagocytic activity tests. YEO was orally administered in zymosan-induced peritonitis, carrageenan-induced leukocyte rolling, and adhesion events in the in situ microcirculation model and in carrageenan-induced paw edema models. YEO (2000 mg/kg) was also tested using an acute toxicity test in Swiss mice. YEO showed a predominance of benzyl acetate, linalool, benzyl benzoate, and methyl benzoate. YEO did not present in vitro cytotoxicity. YEO reduced the in vitro neutrophil chemotaxis induced by fMLP and reduced the phagocytic activity. The oral treatment with YEO reduced the leukocyte recruitment and nitric oxide production in the zymosan-induced peritonitis model, reduced rolling and adherent leukocyte number induced by carrageenan in the in situ microcirculation model, and reduced carrageenan-induced edema and mechanical hyperalgesia. YEO did not present signs of toxicity in the acute toxicity test. In conclusion, YEO affected the leukocyte activation, and presented antiedematogenic, anti-hyperalgesic, and anti-inflammatory properties. |
format | Online Article Text |
id | pubmed-9231162 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-92311622022-06-25 Effect of Ylang-Ylang (Cananga odorata Hook. F. & Thomson) Essential Oil on Acute Inflammatory Response In Vitro and In Vivo de Freitas Junior, Robson Araújo Lossavaro, Paloma Kênia de Moraes Berenguel Kassuya, Cândida Aparecida Leite Paredes-Gamero, Edgar Julian Farias Júnior, Nelson Carvalho Souza, Maria Inês Lenz Silva-Comar, Francielli Maria de Souza Cuman, Roberto Kenji Nakamura Silva, Denise Brentan Toffoli-Kadri, Mônica Cristina Silva-Filho, Saulo Euclides Molecules Article The aim of this study is to evaluate the phytochemical profile, oral acute toxicity, and the effect of ylang-ylang (Cananga odorata Hook. F. & Thomson) essential oil (YEO) on acute inflammation. YEO was analyzed by gas chromatography/mass spectrometry. For in vitro tests, YEO was assessed using cytotoxicity, neutrophil chemotaxis induced by N-formyl methionyl leucyl phenylalanine (fMLP), and phagocytic activity tests. YEO was orally administered in zymosan-induced peritonitis, carrageenan-induced leukocyte rolling, and adhesion events in the in situ microcirculation model and in carrageenan-induced paw edema models. YEO (2000 mg/kg) was also tested using an acute toxicity test in Swiss mice. YEO showed a predominance of benzyl acetate, linalool, benzyl benzoate, and methyl benzoate. YEO did not present in vitro cytotoxicity. YEO reduced the in vitro neutrophil chemotaxis induced by fMLP and reduced the phagocytic activity. The oral treatment with YEO reduced the leukocyte recruitment and nitric oxide production in the zymosan-induced peritonitis model, reduced rolling and adherent leukocyte number induced by carrageenan in the in situ microcirculation model, and reduced carrageenan-induced edema and mechanical hyperalgesia. YEO did not present signs of toxicity in the acute toxicity test. In conclusion, YEO affected the leukocyte activation, and presented antiedematogenic, anti-hyperalgesic, and anti-inflammatory properties. MDPI 2022-06-07 /pmc/articles/PMC9231162/ /pubmed/35744789 http://dx.doi.org/10.3390/molecules27123666 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article de Freitas Junior, Robson Araújo Lossavaro, Paloma Kênia de Moraes Berenguel Kassuya, Cândida Aparecida Leite Paredes-Gamero, Edgar Julian Farias Júnior, Nelson Carvalho Souza, Maria Inês Lenz Silva-Comar, Francielli Maria de Souza Cuman, Roberto Kenji Nakamura Silva, Denise Brentan Toffoli-Kadri, Mônica Cristina Silva-Filho, Saulo Euclides Effect of Ylang-Ylang (Cananga odorata Hook. F. & Thomson) Essential Oil on Acute Inflammatory Response In Vitro and In Vivo |
title | Effect of Ylang-Ylang (Cananga odorata Hook. F. & Thomson) Essential Oil on Acute Inflammatory Response In Vitro and In Vivo |
title_full | Effect of Ylang-Ylang (Cananga odorata Hook. F. & Thomson) Essential Oil on Acute Inflammatory Response In Vitro and In Vivo |
title_fullStr | Effect of Ylang-Ylang (Cananga odorata Hook. F. & Thomson) Essential Oil on Acute Inflammatory Response In Vitro and In Vivo |
title_full_unstemmed | Effect of Ylang-Ylang (Cananga odorata Hook. F. & Thomson) Essential Oil on Acute Inflammatory Response In Vitro and In Vivo |
title_short | Effect of Ylang-Ylang (Cananga odorata Hook. F. & Thomson) Essential Oil on Acute Inflammatory Response In Vitro and In Vivo |
title_sort | effect of ylang-ylang (cananga odorata hook. f. & thomson) essential oil on acute inflammatory response in vitro and in vivo |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9231162/ https://www.ncbi.nlm.nih.gov/pubmed/35744789 http://dx.doi.org/10.3390/molecules27123666 |
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