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HPV and HIV Coinfection in Women from a Southeast Region of Romania—PICOPIV Study

Background and Objectives: Romania faces one of the highest cervical cancer burdens in Europe though it is a preventable cancer through population screening by cytology and human papillomavirus (HPV) detection. Also, it has one of the highest incidences of human immunodeficiency virus (HIV) infectio...

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Autores principales: Cambrea, Simona Claudia, Aschie, Mariana, Resul, Ghiulendan, Mitroi, Anca Florentina, Chisoi, Anca, Nicolau, Antonela Anca, Baltatescu, Gabriela Izabela, Cretu, Ana Maria, Lupasteanu, Gabriela, Serbanescu, Lucian, Manea, Mihaela, Topliceanu, Sebastian Theodor, Petcu, Lucian Cristian, Pazara, Loredana, Cozaru, Georgeta Camelia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9231193/
https://www.ncbi.nlm.nih.gov/pubmed/35744023
http://dx.doi.org/10.3390/medicina58060760
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author Cambrea, Simona Claudia
Aschie, Mariana
Resul, Ghiulendan
Mitroi, Anca Florentina
Chisoi, Anca
Nicolau, Antonela Anca
Baltatescu, Gabriela Izabela
Cretu, Ana Maria
Lupasteanu, Gabriela
Serbanescu, Lucian
Manea, Mihaela
Topliceanu, Sebastian Theodor
Petcu, Lucian Cristian
Pazara, Loredana
Cozaru, Georgeta Camelia
author_facet Cambrea, Simona Claudia
Aschie, Mariana
Resul, Ghiulendan
Mitroi, Anca Florentina
Chisoi, Anca
Nicolau, Antonela Anca
Baltatescu, Gabriela Izabela
Cretu, Ana Maria
Lupasteanu, Gabriela
Serbanescu, Lucian
Manea, Mihaela
Topliceanu, Sebastian Theodor
Petcu, Lucian Cristian
Pazara, Loredana
Cozaru, Georgeta Camelia
author_sort Cambrea, Simona Claudia
collection PubMed
description Background and Objectives: Romania faces one of the highest cervical cancer burdens in Europe though it is a preventable cancer through population screening by cytology and human papillomavirus (HPV) detection. Also, it has one of the highest incidences of human immunodeficiency virus (HIV) infection. HPV and HIV coinfection are frequently encountered. The aim of study was to establish the prevalence of HPV infection among HIV-positive women in Southeast Region of Romania, to genotype high risk HPV types -and to correlate the results with clinical data and cytological cervical lesions. Materials and Methods: 40 HIV-positive women were screened for HPV types and for cytological cervical lesions. The findings were evaluated in correlation with CD4 cell counts, HIV viral load, age at first sexual intercourse, number of sexual partners, vaginal candidiasis, and Gardnerella using statistical methods. Results: 19/40 (47.5%) women were positive for HPV types, 63.15% infected with single HPV type and 36.85% with multiple HPV types. The most frequent types were type: 31 (42.1%), 56 (31.57%), 53 (15.78%). On cytology, 34 (85%) women were found with NILM of which 38.23% were HPV-positive. Fifteen percent of women had abnormal cytology (three ASC-US, three LSIL), and all of them were HPV-positive. Through analyzing the value of CD4 count, women with CD4 count ≤ 200 cells/μL were found to be significantly more likely to be infected with HPV; meanwhile there was no correlation between the detection of HPV types and HIV viral load. Candida or Gardnerella were more often associated with HIV-positive women with HPV, than in women without HPV. Conclusions: Infection with HPV types is common among HIV-positive women in the Southeast Region of Romania and it is associated with age at the beginning of sexual life, number of sexual partners, CD4 value, vaginal candidiasis, and Gardnerella infection.
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spelling pubmed-92311932022-06-25 HPV and HIV Coinfection in Women from a Southeast Region of Romania—PICOPIV Study Cambrea, Simona Claudia Aschie, Mariana Resul, Ghiulendan Mitroi, Anca Florentina Chisoi, Anca Nicolau, Antonela Anca Baltatescu, Gabriela Izabela Cretu, Ana Maria Lupasteanu, Gabriela Serbanescu, Lucian Manea, Mihaela Topliceanu, Sebastian Theodor Petcu, Lucian Cristian Pazara, Loredana Cozaru, Georgeta Camelia Medicina (Kaunas) Article Background and Objectives: Romania faces one of the highest cervical cancer burdens in Europe though it is a preventable cancer through population screening by cytology and human papillomavirus (HPV) detection. Also, it has one of the highest incidences of human immunodeficiency virus (HIV) infection. HPV and HIV coinfection are frequently encountered. The aim of study was to establish the prevalence of HPV infection among HIV-positive women in Southeast Region of Romania, to genotype high risk HPV types -and to correlate the results with clinical data and cytological cervical lesions. Materials and Methods: 40 HIV-positive women were screened for HPV types and for cytological cervical lesions. The findings were evaluated in correlation with CD4 cell counts, HIV viral load, age at first sexual intercourse, number of sexual partners, vaginal candidiasis, and Gardnerella using statistical methods. Results: 19/40 (47.5%) women were positive for HPV types, 63.15% infected with single HPV type and 36.85% with multiple HPV types. The most frequent types were type: 31 (42.1%), 56 (31.57%), 53 (15.78%). On cytology, 34 (85%) women were found with NILM of which 38.23% were HPV-positive. Fifteen percent of women had abnormal cytology (three ASC-US, three LSIL), and all of them were HPV-positive. Through analyzing the value of CD4 count, women with CD4 count ≤ 200 cells/μL were found to be significantly more likely to be infected with HPV; meanwhile there was no correlation between the detection of HPV types and HIV viral load. Candida or Gardnerella were more often associated with HIV-positive women with HPV, than in women without HPV. Conclusions: Infection with HPV types is common among HIV-positive women in the Southeast Region of Romania and it is associated with age at the beginning of sexual life, number of sexual partners, CD4 value, vaginal candidiasis, and Gardnerella infection. MDPI 2022-06-03 /pmc/articles/PMC9231193/ /pubmed/35744023 http://dx.doi.org/10.3390/medicina58060760 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Cambrea, Simona Claudia
Aschie, Mariana
Resul, Ghiulendan
Mitroi, Anca Florentina
Chisoi, Anca
Nicolau, Antonela Anca
Baltatescu, Gabriela Izabela
Cretu, Ana Maria
Lupasteanu, Gabriela
Serbanescu, Lucian
Manea, Mihaela
Topliceanu, Sebastian Theodor
Petcu, Lucian Cristian
Pazara, Loredana
Cozaru, Georgeta Camelia
HPV and HIV Coinfection in Women from a Southeast Region of Romania—PICOPIV Study
title HPV and HIV Coinfection in Women from a Southeast Region of Romania—PICOPIV Study
title_full HPV and HIV Coinfection in Women from a Southeast Region of Romania—PICOPIV Study
title_fullStr HPV and HIV Coinfection in Women from a Southeast Region of Romania—PICOPIV Study
title_full_unstemmed HPV and HIV Coinfection in Women from a Southeast Region of Romania—PICOPIV Study
title_short HPV and HIV Coinfection in Women from a Southeast Region of Romania—PICOPIV Study
title_sort hpv and hiv coinfection in women from a southeast region of romania—picopiv study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9231193/
https://www.ncbi.nlm.nih.gov/pubmed/35744023
http://dx.doi.org/10.3390/medicina58060760
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