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Identification of Serum Oxylipins Associated with the Development of Coronary Artery Disease: A Nested Case-Control Study
Coronary artery disease (CAD) is among the leading causes of death globally. The American Heart Association recommends that people should consume more PUFA-rich plant foods to replace SFA-rich ones to lower serum cholesterol and prevent CAD. However, PUFA may be susceptible to oxidation and generate...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9231201/ https://www.ncbi.nlm.nih.gov/pubmed/35736428 http://dx.doi.org/10.3390/metabo12060495 |
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author | Chiang, Kuang-Mao Chen, Jia-Fu Yang, Chin-An Xiu, Lili Yang, Hsin-Chou Shyur, Lie-Fen Pan, Wen-Harn |
author_facet | Chiang, Kuang-Mao Chen, Jia-Fu Yang, Chin-An Xiu, Lili Yang, Hsin-Chou Shyur, Lie-Fen Pan, Wen-Harn |
author_sort | Chiang, Kuang-Mao |
collection | PubMed |
description | Coronary artery disease (CAD) is among the leading causes of death globally. The American Heart Association recommends that people should consume more PUFA-rich plant foods to replace SFA-rich ones to lower serum cholesterol and prevent CAD. However, PUFA may be susceptible to oxidation and generate oxidized products such as oxylipins. In this study, we investigated whether the blood oxylipin profile is associated with the risk of developing CAD and whether including identified oxylipins may improve the predictability of CAD risk. We designed a nested case-control study with 77 cases and 148 matched controls from a 10-year follow-up of the Nutrition and Health Survey in a Taiwanese cohort of 720 people aged 50 to 70. A panel of 46 oxylipins was measured for baseline serum samples. We discovered four oxylipins associated with CAD risk. 13-oxo-ODE, which has been previously found in formed plagues, was positively associated with CAD (OR = 5.02, 95%CI = 0.85 to 15.6). PGE2/PGD2, previously shown to increase cardiac output, was inversely associated (OR = 0.16, 95%CI = 0.06 to 0.42). 15-deoxy-PGJ2, with anti-inflammatory and anti-apoptosis effects on cardiomyocytes (OR = 0.26, 95%CI = 0.09 to 0.76), and 5-HETE, which was associated with inflammation (OR = 0.28, 95%CI = 0.10 to 0.78), were also negatively associated as protective factors. Adding these four oxylipins to the traditional risk prediction model significantly improved CAD prediction. |
format | Online Article Text |
id | pubmed-9231201 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-92312012022-06-25 Identification of Serum Oxylipins Associated with the Development of Coronary Artery Disease: A Nested Case-Control Study Chiang, Kuang-Mao Chen, Jia-Fu Yang, Chin-An Xiu, Lili Yang, Hsin-Chou Shyur, Lie-Fen Pan, Wen-Harn Metabolites Article Coronary artery disease (CAD) is among the leading causes of death globally. The American Heart Association recommends that people should consume more PUFA-rich plant foods to replace SFA-rich ones to lower serum cholesterol and prevent CAD. However, PUFA may be susceptible to oxidation and generate oxidized products such as oxylipins. In this study, we investigated whether the blood oxylipin profile is associated with the risk of developing CAD and whether including identified oxylipins may improve the predictability of CAD risk. We designed a nested case-control study with 77 cases and 148 matched controls from a 10-year follow-up of the Nutrition and Health Survey in a Taiwanese cohort of 720 people aged 50 to 70. A panel of 46 oxylipins was measured for baseline serum samples. We discovered four oxylipins associated with CAD risk. 13-oxo-ODE, which has been previously found in formed plagues, was positively associated with CAD (OR = 5.02, 95%CI = 0.85 to 15.6). PGE2/PGD2, previously shown to increase cardiac output, was inversely associated (OR = 0.16, 95%CI = 0.06 to 0.42). 15-deoxy-PGJ2, with anti-inflammatory and anti-apoptosis effects on cardiomyocytes (OR = 0.26, 95%CI = 0.09 to 0.76), and 5-HETE, which was associated with inflammation (OR = 0.28, 95%CI = 0.10 to 0.78), were also negatively associated as protective factors. Adding these four oxylipins to the traditional risk prediction model significantly improved CAD prediction. MDPI 2022-05-30 /pmc/articles/PMC9231201/ /pubmed/35736428 http://dx.doi.org/10.3390/metabo12060495 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Chiang, Kuang-Mao Chen, Jia-Fu Yang, Chin-An Xiu, Lili Yang, Hsin-Chou Shyur, Lie-Fen Pan, Wen-Harn Identification of Serum Oxylipins Associated with the Development of Coronary Artery Disease: A Nested Case-Control Study |
title | Identification of Serum Oxylipins Associated with the Development of Coronary Artery Disease: A Nested Case-Control Study |
title_full | Identification of Serum Oxylipins Associated with the Development of Coronary Artery Disease: A Nested Case-Control Study |
title_fullStr | Identification of Serum Oxylipins Associated with the Development of Coronary Artery Disease: A Nested Case-Control Study |
title_full_unstemmed | Identification of Serum Oxylipins Associated with the Development of Coronary Artery Disease: A Nested Case-Control Study |
title_short | Identification of Serum Oxylipins Associated with the Development of Coronary Artery Disease: A Nested Case-Control Study |
title_sort | identification of serum oxylipins associated with the development of coronary artery disease: a nested case-control study |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9231201/ https://www.ncbi.nlm.nih.gov/pubmed/35736428 http://dx.doi.org/10.3390/metabo12060495 |
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