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Identification of Serum Oxylipins Associated with the Development of Coronary Artery Disease: A Nested Case-Control Study

Coronary artery disease (CAD) is among the leading causes of death globally. The American Heart Association recommends that people should consume more PUFA-rich plant foods to replace SFA-rich ones to lower serum cholesterol and prevent CAD. However, PUFA may be susceptible to oxidation and generate...

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Autores principales: Chiang, Kuang-Mao, Chen, Jia-Fu, Yang, Chin-An, Xiu, Lili, Yang, Hsin-Chou, Shyur, Lie-Fen, Pan, Wen-Harn
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9231201/
https://www.ncbi.nlm.nih.gov/pubmed/35736428
http://dx.doi.org/10.3390/metabo12060495
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author Chiang, Kuang-Mao
Chen, Jia-Fu
Yang, Chin-An
Xiu, Lili
Yang, Hsin-Chou
Shyur, Lie-Fen
Pan, Wen-Harn
author_facet Chiang, Kuang-Mao
Chen, Jia-Fu
Yang, Chin-An
Xiu, Lili
Yang, Hsin-Chou
Shyur, Lie-Fen
Pan, Wen-Harn
author_sort Chiang, Kuang-Mao
collection PubMed
description Coronary artery disease (CAD) is among the leading causes of death globally. The American Heart Association recommends that people should consume more PUFA-rich plant foods to replace SFA-rich ones to lower serum cholesterol and prevent CAD. However, PUFA may be susceptible to oxidation and generate oxidized products such as oxylipins. In this study, we investigated whether the blood oxylipin profile is associated with the risk of developing CAD and whether including identified oxylipins may improve the predictability of CAD risk. We designed a nested case-control study with 77 cases and 148 matched controls from a 10-year follow-up of the Nutrition and Health Survey in a Taiwanese cohort of 720 people aged 50 to 70. A panel of 46 oxylipins was measured for baseline serum samples. We discovered four oxylipins associated with CAD risk. 13-oxo-ODE, which has been previously found in formed plagues, was positively associated with CAD (OR = 5.02, 95%CI = 0.85 to 15.6). PGE2/PGD2, previously shown to increase cardiac output, was inversely associated (OR = 0.16, 95%CI = 0.06 to 0.42). 15-deoxy-PGJ2, with anti-inflammatory and anti-apoptosis effects on cardiomyocytes (OR = 0.26, 95%CI = 0.09 to 0.76), and 5-HETE, which was associated with inflammation (OR = 0.28, 95%CI = 0.10 to 0.78), were also negatively associated as protective factors. Adding these four oxylipins to the traditional risk prediction model significantly improved CAD prediction.
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spelling pubmed-92312012022-06-25 Identification of Serum Oxylipins Associated with the Development of Coronary Artery Disease: A Nested Case-Control Study Chiang, Kuang-Mao Chen, Jia-Fu Yang, Chin-An Xiu, Lili Yang, Hsin-Chou Shyur, Lie-Fen Pan, Wen-Harn Metabolites Article Coronary artery disease (CAD) is among the leading causes of death globally. The American Heart Association recommends that people should consume more PUFA-rich plant foods to replace SFA-rich ones to lower serum cholesterol and prevent CAD. However, PUFA may be susceptible to oxidation and generate oxidized products such as oxylipins. In this study, we investigated whether the blood oxylipin profile is associated with the risk of developing CAD and whether including identified oxylipins may improve the predictability of CAD risk. We designed a nested case-control study with 77 cases and 148 matched controls from a 10-year follow-up of the Nutrition and Health Survey in a Taiwanese cohort of 720 people aged 50 to 70. A panel of 46 oxylipins was measured for baseline serum samples. We discovered four oxylipins associated with CAD risk. 13-oxo-ODE, which has been previously found in formed plagues, was positively associated with CAD (OR = 5.02, 95%CI = 0.85 to 15.6). PGE2/PGD2, previously shown to increase cardiac output, was inversely associated (OR = 0.16, 95%CI = 0.06 to 0.42). 15-deoxy-PGJ2, with anti-inflammatory and anti-apoptosis effects on cardiomyocytes (OR = 0.26, 95%CI = 0.09 to 0.76), and 5-HETE, which was associated with inflammation (OR = 0.28, 95%CI = 0.10 to 0.78), were also negatively associated as protective factors. Adding these four oxylipins to the traditional risk prediction model significantly improved CAD prediction. MDPI 2022-05-30 /pmc/articles/PMC9231201/ /pubmed/35736428 http://dx.doi.org/10.3390/metabo12060495 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Chiang, Kuang-Mao
Chen, Jia-Fu
Yang, Chin-An
Xiu, Lili
Yang, Hsin-Chou
Shyur, Lie-Fen
Pan, Wen-Harn
Identification of Serum Oxylipins Associated with the Development of Coronary Artery Disease: A Nested Case-Control Study
title Identification of Serum Oxylipins Associated with the Development of Coronary Artery Disease: A Nested Case-Control Study
title_full Identification of Serum Oxylipins Associated with the Development of Coronary Artery Disease: A Nested Case-Control Study
title_fullStr Identification of Serum Oxylipins Associated with the Development of Coronary Artery Disease: A Nested Case-Control Study
title_full_unstemmed Identification of Serum Oxylipins Associated with the Development of Coronary Artery Disease: A Nested Case-Control Study
title_short Identification of Serum Oxylipins Associated with the Development of Coronary Artery Disease: A Nested Case-Control Study
title_sort identification of serum oxylipins associated with the development of coronary artery disease: a nested case-control study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9231201/
https://www.ncbi.nlm.nih.gov/pubmed/35736428
http://dx.doi.org/10.3390/metabo12060495
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