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Mammary Fibroadenoma in Cats: A Matter of Classification

Benign mammary lesions are infrequent in cats. Among these, the most common is feline fibroadenomatous change, a hyperplastic/dysplastic change associated with hormonal imbalances. Although never thoroughly described in scientific literature, feline fibroadenomas, which share some morphological feat...

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Autores principales: Torrigiani, Filippo, Moccia, Valentina, Brunetti, Barbara, Millanta, Francesca, Valdivia, Guillermo, Peña, Laura, Cavicchioli, Laura, Zappulli, Valentina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9231207/
https://www.ncbi.nlm.nih.gov/pubmed/35737305
http://dx.doi.org/10.3390/vetsci9060253
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author Torrigiani, Filippo
Moccia, Valentina
Brunetti, Barbara
Millanta, Francesca
Valdivia, Guillermo
Peña, Laura
Cavicchioli, Laura
Zappulli, Valentina
author_facet Torrigiani, Filippo
Moccia, Valentina
Brunetti, Barbara
Millanta, Francesca
Valdivia, Guillermo
Peña, Laura
Cavicchioli, Laura
Zappulli, Valentina
author_sort Torrigiani, Filippo
collection PubMed
description Benign mammary lesions are infrequent in cats. Among these, the most common is feline fibroadenomatous change, a hyperplastic/dysplastic change associated with hormonal imbalances. Although never thoroughly described in scientific literature, feline fibroadenomas, which share some morphological features with fibroadenomatous change, have been variably included in classification systems. The aim of this study was to characterise feline mammary fibroadenomas from a histological and immunophenotypical point of view in order to allow the standardisation of classification. Nine cases were retrospectively collected from eight female and one male cat with no history of hormonal stimulation. Diagnostic inclusion criteria were defined and immunohistochemistry was performed. Histologically, nodules were composed of neoplastic epithelial cells arranged in arborizing lobular-like structures surrounded by abundant proliferating stroma. In all analysed cases, epithelial elements showed immunolabelling for pancytokeratin, cytokeratin19, and β-catenin. Interestingly, five cases showed multifocal epithelial vimentin positivity. Epithelial nuclear oestrogen receptor positivity was observed in three of the nine samples. In all cases, myoepithelial cells did not extend into the interstitium. Stromal cells expressed vimentin, calponin, and mild β-catenin. The median Ki67 scores were 18% and 8.3% in the epithelial and stromal components, respectively. This study describes, for the first time, the morphological and immunophenotypical features of feline mammary fibroadenoma, highlighting its existence as a separate entity from fibroadenomatous change.
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spelling pubmed-92312072022-06-25 Mammary Fibroadenoma in Cats: A Matter of Classification Torrigiani, Filippo Moccia, Valentina Brunetti, Barbara Millanta, Francesca Valdivia, Guillermo Peña, Laura Cavicchioli, Laura Zappulli, Valentina Vet Sci Article Benign mammary lesions are infrequent in cats. Among these, the most common is feline fibroadenomatous change, a hyperplastic/dysplastic change associated with hormonal imbalances. Although never thoroughly described in scientific literature, feline fibroadenomas, which share some morphological features with fibroadenomatous change, have been variably included in classification systems. The aim of this study was to characterise feline mammary fibroadenomas from a histological and immunophenotypical point of view in order to allow the standardisation of classification. Nine cases were retrospectively collected from eight female and one male cat with no history of hormonal stimulation. Diagnostic inclusion criteria were defined and immunohistochemistry was performed. Histologically, nodules were composed of neoplastic epithelial cells arranged in arborizing lobular-like structures surrounded by abundant proliferating stroma. In all analysed cases, epithelial elements showed immunolabelling for pancytokeratin, cytokeratin19, and β-catenin. Interestingly, five cases showed multifocal epithelial vimentin positivity. Epithelial nuclear oestrogen receptor positivity was observed in three of the nine samples. In all cases, myoepithelial cells did not extend into the interstitium. Stromal cells expressed vimentin, calponin, and mild β-catenin. The median Ki67 scores were 18% and 8.3% in the epithelial and stromal components, respectively. This study describes, for the first time, the morphological and immunophenotypical features of feline mammary fibroadenoma, highlighting its existence as a separate entity from fibroadenomatous change. MDPI 2022-05-26 /pmc/articles/PMC9231207/ /pubmed/35737305 http://dx.doi.org/10.3390/vetsci9060253 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Torrigiani, Filippo
Moccia, Valentina
Brunetti, Barbara
Millanta, Francesca
Valdivia, Guillermo
Peña, Laura
Cavicchioli, Laura
Zappulli, Valentina
Mammary Fibroadenoma in Cats: A Matter of Classification
title Mammary Fibroadenoma in Cats: A Matter of Classification
title_full Mammary Fibroadenoma in Cats: A Matter of Classification
title_fullStr Mammary Fibroadenoma in Cats: A Matter of Classification
title_full_unstemmed Mammary Fibroadenoma in Cats: A Matter of Classification
title_short Mammary Fibroadenoma in Cats: A Matter of Classification
title_sort mammary fibroadenoma in cats: a matter of classification
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9231207/
https://www.ncbi.nlm.nih.gov/pubmed/35737305
http://dx.doi.org/10.3390/vetsci9060253
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