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Gene Targeting to the Cerebral Cortex Following Intranasal Administration of Polyplexes

Gene delivery to the cerebral cortex is challenging due to the blood brain barrier and the labile and macromolecular nature of DNA. Here we report gene delivery to the cortex using a glycol chitosan—DNA polyplex (GCP). In vitro, GCPs carrying a reporter plasmid DNA showed approximately 60% of the tr...

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Detalles Bibliográficos
Autores principales:	Petkova, Asya I., Kubajewska, Ilona, Vaideanu, Alexandra, Schätzlein, Andreas G., Uchegbu, Ijeoma F.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9231247/ https://www.ncbi.nlm.nih.gov/pubmed/35745709 http://dx.doi.org/10.3390/pharmaceutics14061136

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