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Mechanistic Analysis of Chemically Diverse Bromodomain-4 Inhibitors Using Balanced QSAR Analysis and Supported by X-ray Resolved Crystal Structures

Bromodomain-4 (BRD-4) is a key enzyme in post-translational modifications, transcriptional activation, and many other cellular processes. Its inhibitors find their therapeutic usage in cancer, acute heart failure, and inflammation to name a few. In the present study, a dataset of 980 molecules with...

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Detalles Bibliográficos
Autores principales:	Zaki, Magdi E. A., Al-Hussain, Sami A., Al-Mutairi, Aamal A., Masand, Vijay H., Samad, Abdul, Jawarkar, Rahul D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9231298/ https://www.ncbi.nlm.nih.gov/pubmed/35745664 http://dx.doi.org/10.3390/ph15060745

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