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Indoxyl Sulfate Induces Oxidative Changes in Plasma and Hemolysate
The deteriorating function of the kidneys in chronic kidney disease (CKD) is associated, among other things, with the retention of many unnecessary metabolic products in the body. Indoxyl sulfate (IS) belongs to the group of uremic toxins with a high protein binding affinity. Moreover, this compound...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9231308/ https://www.ncbi.nlm.nih.gov/pubmed/35744968 http://dx.doi.org/10.3390/molecules27123848 |
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author | Pieniazek, Anna Kopera, Michal Gwozdzinski, Lukasz Gwozdzinski, Krzysztof |
author_facet | Pieniazek, Anna Kopera, Michal Gwozdzinski, Lukasz Gwozdzinski, Krzysztof |
author_sort | Pieniazek, Anna |
collection | PubMed |
description | The deteriorating function of the kidneys in chronic kidney disease (CKD) is associated, among other things, with the retention of many unnecessary metabolic products in the body. Indoxyl sulfate (IS) belongs to the group of uremic toxins with a high protein binding affinity. Moreover, this compound can generate oxidative stress. We hypothesized that a high concentration of IS might induce oxidative changes in erythrocytes and plasma components, and could therefore contribute to CKD progression. In this study, we evaluated the influence of IS on the oxidative stress parameters in plasma and hemolysate. Moreover, as a result of the action of IS, we observed a decrease in the total antioxidant capacity and a change in the activity of catalase and superoxide dismutase in hemolysate and plasma. The obtained results indicate that IS induces oxidative damage to hemolysate and plasma components. Greater changes in the parameters of oxidative stress were observed in hemolysate than in plasma treated with indoxyl sulfate. The obtained results suggest that the increased concentration of IS in patients with chronic kidney disease may lead to a decrease in the lifespan of erythrocytes in their bloodstream. |
format | Online Article Text |
id | pubmed-9231308 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-92313082022-06-25 Indoxyl Sulfate Induces Oxidative Changes in Plasma and Hemolysate Pieniazek, Anna Kopera, Michal Gwozdzinski, Lukasz Gwozdzinski, Krzysztof Molecules Article The deteriorating function of the kidneys in chronic kidney disease (CKD) is associated, among other things, with the retention of many unnecessary metabolic products in the body. Indoxyl sulfate (IS) belongs to the group of uremic toxins with a high protein binding affinity. Moreover, this compound can generate oxidative stress. We hypothesized that a high concentration of IS might induce oxidative changes in erythrocytes and plasma components, and could therefore contribute to CKD progression. In this study, we evaluated the influence of IS on the oxidative stress parameters in plasma and hemolysate. Moreover, as a result of the action of IS, we observed a decrease in the total antioxidant capacity and a change in the activity of catalase and superoxide dismutase in hemolysate and plasma. The obtained results indicate that IS induces oxidative damage to hemolysate and plasma components. Greater changes in the parameters of oxidative stress were observed in hemolysate than in plasma treated with indoxyl sulfate. The obtained results suggest that the increased concentration of IS in patients with chronic kidney disease may lead to a decrease in the lifespan of erythrocytes in their bloodstream. MDPI 2022-06-15 /pmc/articles/PMC9231308/ /pubmed/35744968 http://dx.doi.org/10.3390/molecules27123848 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Pieniazek, Anna Kopera, Michal Gwozdzinski, Lukasz Gwozdzinski, Krzysztof Indoxyl Sulfate Induces Oxidative Changes in Plasma and Hemolysate |
title | Indoxyl Sulfate Induces Oxidative Changes in Plasma and Hemolysate |
title_full | Indoxyl Sulfate Induces Oxidative Changes in Plasma and Hemolysate |
title_fullStr | Indoxyl Sulfate Induces Oxidative Changes in Plasma and Hemolysate |
title_full_unstemmed | Indoxyl Sulfate Induces Oxidative Changes in Plasma and Hemolysate |
title_short | Indoxyl Sulfate Induces Oxidative Changes in Plasma and Hemolysate |
title_sort | indoxyl sulfate induces oxidative changes in plasma and hemolysate |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9231308/ https://www.ncbi.nlm.nih.gov/pubmed/35744968 http://dx.doi.org/10.3390/molecules27123848 |
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