Catalytic Enantioselective Cyclopropylalkynylation of Aldimines Generated In Situ from α-Amido Sulfones

A convenient procedure of synthesis of N-carbamoyl-protected propargylic amines substituted with a cyclopropyl group from α-amido sulfones and cyclopropylacetylene is described. The reaction is catalyzed by a chiral BINOL-type zinc complex and provides the corresponding products in good yields and e...

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Detalles Bibliográficos
Autores principales: Monleón, Alicia, Blay, Gonzalo, Pedro, José R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9231313/
https://www.ncbi.nlm.nih.gov/pubmed/35744889
http://dx.doi.org/10.3390/molecules27123763
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author Monleón, Alicia
Blay, Gonzalo
Pedro, José R.
author_facet Monleón, Alicia
Blay, Gonzalo
Pedro, José R.
author_sort Monleón, Alicia
collection PubMed
description A convenient procedure of synthesis of N-carbamoyl-protected propargylic amines substituted with a cyclopropyl group from α-amido sulfones and cyclopropylacetylene is described. The reaction is catalyzed by a chiral BINOL-type zinc complex and provides the corresponding products in good yields and enantioselectivities.
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spelling pubmed-92313132022-06-25 Catalytic Enantioselective Cyclopropylalkynylation of Aldimines Generated In Situ from α-Amido Sulfones Monleón, Alicia Blay, Gonzalo Pedro, José R. Molecules Article A convenient procedure of synthesis of N-carbamoyl-protected propargylic amines substituted with a cyclopropyl group from α-amido sulfones and cyclopropylacetylene is described. The reaction is catalyzed by a chiral BINOL-type zinc complex and provides the corresponding products in good yields and enantioselectivities. MDPI 2022-06-11 /pmc/articles/PMC9231313/ /pubmed/35744889 http://dx.doi.org/10.3390/molecules27123763 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Monleón, Alicia
Blay, Gonzalo
Pedro, José R.
Catalytic Enantioselective Cyclopropylalkynylation of Aldimines Generated In Situ from α-Amido Sulfones
title Catalytic Enantioselective Cyclopropylalkynylation of Aldimines Generated In Situ from α-Amido Sulfones
title_full Catalytic Enantioselective Cyclopropylalkynylation of Aldimines Generated In Situ from α-Amido Sulfones
title_fullStr Catalytic Enantioselective Cyclopropylalkynylation of Aldimines Generated In Situ from α-Amido Sulfones
title_full_unstemmed Catalytic Enantioselective Cyclopropylalkynylation of Aldimines Generated In Situ from α-Amido Sulfones
title_short Catalytic Enantioselective Cyclopropylalkynylation of Aldimines Generated In Situ from α-Amido Sulfones
title_sort catalytic enantioselective cyclopropylalkynylation of aldimines generated in situ from α-amido sulfones
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9231313/
https://www.ncbi.nlm.nih.gov/pubmed/35744889
http://dx.doi.org/10.3390/molecules27123763
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AT blaygonzalo catalyticenantioselectivecyclopropylalkynylationofaldiminesgeneratedinsitufromaamidosulfones
AT pedrojoser catalyticenantioselectivecyclopropylalkynylationofaldiminesgeneratedinsitufromaamidosulfones

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