Memory-like NK cells armed with a neoepitope-specific CAR exhibit potent activity against NPM1 mutated acute myeloid leukemia

Acute myeloid leukemia (AML) remains a therapeutic challenge, and a paucity of tumor-specific targets has significantly hampered the development of effective immune-based therapies. Recent paradigm-changing studies have shown that natural killer (NK) cells exhibit innate memory upon brief activation...

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Detalles Bibliográficos
Autores principales: Dong, Han, Ham, James Dongjoo, Hu, Guangan, Xie, Guozhu, Vergara, Juliana, Liang, Yong, Ali, Alaa, Tarannum, Mubin, Donner, Hannah, Baginska, Joanna, Abdulhamid, Yasmin, Dinh, Khanhlinh, Soiffer, Robert J., Ritz, Jerome, Glimcher, Laurie H., Chen, Jianzhu, Romee, Rizwan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9231490/
https://www.ncbi.nlm.nih.gov/pubmed/35696582
http://dx.doi.org/10.1073/pnas.2122379119

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