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Rab11-FIP1/RCP Functions as a Major Signalling Hub in the Oncogenic Roles of Mutant p53 in Cancer

Rab11-FIP1 is a Rab effector protein that is involved in endosomal recycling and trafficking of various molecules throughout the endocytic compartments of the cell. The consequence of this can be increased secretion or increased membrane expression of those molecules. In general, expression of Rab11...

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Autores principales: von Grabowiecki, Yannick, Phatak, Vinaya, Aschauer, Lydia, Muller, Patricia A. J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9231559/
https://www.ncbi.nlm.nih.gov/pubmed/35757381
http://dx.doi.org/10.3389/fonc.2021.804107
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author von Grabowiecki, Yannick
Phatak, Vinaya
Aschauer, Lydia
Muller, Patricia A. J.
author_facet von Grabowiecki, Yannick
Phatak, Vinaya
Aschauer, Lydia
Muller, Patricia A. J.
author_sort von Grabowiecki, Yannick
collection PubMed
description Rab11-FIP1 is a Rab effector protein that is involved in endosomal recycling and trafficking of various molecules throughout the endocytic compartments of the cell. The consequence of this can be increased secretion or increased membrane expression of those molecules. In general, expression of Rab11-FIP1 coincides with more tumourigenic and metastatic cell behaviour. Rab11-FIP1 can work in concert with oncogenes such as mutant p53, but has also been speculated to be an oncogene in its own right. In this perspective, we will discuss and speculate upon our observations that mutant p53 promotes Rab11-FIP1 function to not only promote invasive behaviour, but also chemoresistance by regulating a multitude of different proteins.
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spelling pubmed-92315592022-06-25 Rab11-FIP1/RCP Functions as a Major Signalling Hub in the Oncogenic Roles of Mutant p53 in Cancer von Grabowiecki, Yannick Phatak, Vinaya Aschauer, Lydia Muller, Patricia A. J. Front Oncol Oncology Rab11-FIP1 is a Rab effector protein that is involved in endosomal recycling and trafficking of various molecules throughout the endocytic compartments of the cell. The consequence of this can be increased secretion or increased membrane expression of those molecules. In general, expression of Rab11-FIP1 coincides with more tumourigenic and metastatic cell behaviour. Rab11-FIP1 can work in concert with oncogenes such as mutant p53, but has also been speculated to be an oncogene in its own right. In this perspective, we will discuss and speculate upon our observations that mutant p53 promotes Rab11-FIP1 function to not only promote invasive behaviour, but also chemoresistance by regulating a multitude of different proteins. Frontiers Media S.A. 2021-12-21 /pmc/articles/PMC9231559/ /pubmed/35757381 http://dx.doi.org/10.3389/fonc.2021.804107 Text en Copyright © 2021 von Grabowiecki, Phatak, Aschauer and Muller https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
von Grabowiecki, Yannick
Phatak, Vinaya
Aschauer, Lydia
Muller, Patricia A. J.
Rab11-FIP1/RCP Functions as a Major Signalling Hub in the Oncogenic Roles of Mutant p53 in Cancer
title Rab11-FIP1/RCP Functions as a Major Signalling Hub in the Oncogenic Roles of Mutant p53 in Cancer
title_full Rab11-FIP1/RCP Functions as a Major Signalling Hub in the Oncogenic Roles of Mutant p53 in Cancer
title_fullStr Rab11-FIP1/RCP Functions as a Major Signalling Hub in the Oncogenic Roles of Mutant p53 in Cancer
title_full_unstemmed Rab11-FIP1/RCP Functions as a Major Signalling Hub in the Oncogenic Roles of Mutant p53 in Cancer
title_short Rab11-FIP1/RCP Functions as a Major Signalling Hub in the Oncogenic Roles of Mutant p53 in Cancer
title_sort rab11-fip1/rcp functions as a major signalling hub in the oncogenic roles of mutant p53 in cancer
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9231559/
https://www.ncbi.nlm.nih.gov/pubmed/35757381
http://dx.doi.org/10.3389/fonc.2021.804107
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