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Neurological Consequences of COVID-19: A Curious Case of Delayed Onset Guillain-Barre

SARS-CoV-2 is responsible for causing the COVID-19 pandemic and over 4 million deaths globally. Clinical symptoms range from asymptomatic infection, viral syndrome, and pneumonia, to acute respiratory distress syndrome. Guillain-Barre syndrome (GBS), an acute demyelinating inflammatory polyneuropath...

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Autores principales: Devarakonda, Aditya K, Stumpe, Tanner R, Saucier, Ashley N, Riley, Thaddeus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9231646/
https://www.ncbi.nlm.nih.gov/pubmed/35761907
http://dx.doi.org/10.7759/cureus.25325
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author Devarakonda, Aditya K
Stumpe, Tanner R
Saucier, Ashley N
Riley, Thaddeus
author_facet Devarakonda, Aditya K
Stumpe, Tanner R
Saucier, Ashley N
Riley, Thaddeus
author_sort Devarakonda, Aditya K
collection PubMed
description SARS-CoV-2 is responsible for causing the COVID-19 pandemic and over 4 million deaths globally. Clinical symptoms range from asymptomatic infection, viral syndrome, and pneumonia, to acute respiratory distress syndrome. Guillain-Barre syndrome (GBS), an acute demyelinating inflammatory polyneuropathy, may be a manifestation of infection and must be recognized quickly by clinicians to avoid neurological deterioration in these patients. Here, we present an interesting case of GBS in a patient with a previous COVID-19 infection. A 63-year-old male with a past medical history of hypertension, chronic obstructive pulmonary disease, obesity, and recent COVID-19 infection just five weeks prior to the presentation without COVID-19 vaccination presented to a family medicine clinic due to a history of falls as well as lower extremity numbness, weakness, and paresthesias for the past 36 hours. The patient’s MRI and lumbar puncture were unremarkable and the patient was transferred to a tertiary care center. The patient was diagnosed with GBS secondary to his COVID-19 infection five weeks prior. He received a standard five-dose regimen of 400 mg/kg/day of intravenous immunoglobulin and demonstrated rapid improvement in response to therapy. Temporal factors associated with disease such as the seemingly delayed onset of symptoms after COVID-19 viral infection in comparison to other cases of GBS, as well as the rapid progression of symptomatology, are of note. Healthcare providers should still consider GBS as a possibility in patients with a relatively distant history of COVID-19 infections. Rapid progression of symptoms should also be monitored as this may result in earlier respiratory morbidity and mortality in the absence of appropriate diagnosis and treatment.
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spelling pubmed-92316462022-06-26 Neurological Consequences of COVID-19: A Curious Case of Delayed Onset Guillain-Barre Devarakonda, Aditya K Stumpe, Tanner R Saucier, Ashley N Riley, Thaddeus Cureus Family/General Practice SARS-CoV-2 is responsible for causing the COVID-19 pandemic and over 4 million deaths globally. Clinical symptoms range from asymptomatic infection, viral syndrome, and pneumonia, to acute respiratory distress syndrome. Guillain-Barre syndrome (GBS), an acute demyelinating inflammatory polyneuropathy, may be a manifestation of infection and must be recognized quickly by clinicians to avoid neurological deterioration in these patients. Here, we present an interesting case of GBS in a patient with a previous COVID-19 infection. A 63-year-old male with a past medical history of hypertension, chronic obstructive pulmonary disease, obesity, and recent COVID-19 infection just five weeks prior to the presentation without COVID-19 vaccination presented to a family medicine clinic due to a history of falls as well as lower extremity numbness, weakness, and paresthesias for the past 36 hours. The patient’s MRI and lumbar puncture were unremarkable and the patient was transferred to a tertiary care center. The patient was diagnosed with GBS secondary to his COVID-19 infection five weeks prior. He received a standard five-dose regimen of 400 mg/kg/day of intravenous immunoglobulin and demonstrated rapid improvement in response to therapy. Temporal factors associated with disease such as the seemingly delayed onset of symptoms after COVID-19 viral infection in comparison to other cases of GBS, as well as the rapid progression of symptomatology, are of note. Healthcare providers should still consider GBS as a possibility in patients with a relatively distant history of COVID-19 infections. Rapid progression of symptoms should also be monitored as this may result in earlier respiratory morbidity and mortality in the absence of appropriate diagnosis and treatment. Cureus 2022-05-25 /pmc/articles/PMC9231646/ /pubmed/35761907 http://dx.doi.org/10.7759/cureus.25325 Text en Copyright © 2022, Devarakonda et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Family/General Practice
Devarakonda, Aditya K
Stumpe, Tanner R
Saucier, Ashley N
Riley, Thaddeus
Neurological Consequences of COVID-19: A Curious Case of Delayed Onset Guillain-Barre
title Neurological Consequences of COVID-19: A Curious Case of Delayed Onset Guillain-Barre
title_full Neurological Consequences of COVID-19: A Curious Case of Delayed Onset Guillain-Barre
title_fullStr Neurological Consequences of COVID-19: A Curious Case of Delayed Onset Guillain-Barre
title_full_unstemmed Neurological Consequences of COVID-19: A Curious Case of Delayed Onset Guillain-Barre
title_short Neurological Consequences of COVID-19: A Curious Case of Delayed Onset Guillain-Barre
title_sort neurological consequences of covid-19: a curious case of delayed onset guillain-barre
topic Family/General Practice
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9231646/
https://www.ncbi.nlm.nih.gov/pubmed/35761907
http://dx.doi.org/10.7759/cureus.25325
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