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Characterization of the membrane interactions of phospholipase Cγ reveals key features of the active enzyme
PLCγ enzymes are autoinhibited in resting cells and form key components of intracellular signaling that are also linked to disease development. Insights into physiological and aberrant activation of PLCγ require understanding of an active, membrane-bound form, which can hydrolyze inositol-lipid subs...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Association for the Advancement of Science
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9232102/ https://www.ncbi.nlm.nih.gov/pubmed/35749497 http://dx.doi.org/10.1126/sciadv.abp9688 |