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Human organ rejuvenation by VEGF-A: Lessons from the skin

Transplanting aged human skin onto young SCID/beige mice morphologically rejuvenates the xenotransplants. This is accompanied by angiogenesis, epidermal repigmentation, and substantial improvements in key aging-associated biomarkers, including ß-galactosidase, p16(ink4a), SIRT1, PGC1α, collagen 17A,...

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Detalles Bibliográficos
Autores principales:	Keren, Aviad, Bertolini, Marta, Keren, Yaniv, Ullmann, Yehuda, Paus, Ralf, Gilhar, Amos
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Association for the Advancement of Science 2022
Materias:	Biomedicine and Life Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9232104/ https://www.ncbi.nlm.nih.gov/pubmed/35749494 http://dx.doi.org/10.1126/sciadv.abm6756

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