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Orally efficacious lead of the AVG inhibitor series targeting a dynamic interface in the respiratory syncytial virus polymerase

Respiratory syncytial virus (RSV) is a leading cause of lower respiratory infections in infants and the immunocompromised, yet no efficient therapeutic exists. We have identified the AVG class of allosteric inhibitors of RSV RNA synthesis. Here, we demonstrate through biolayer interferometry and in...

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Detalles Bibliográficos
Autores principales:	Sourimant, Julien, Lieber, Carolin M., Yoon, Jeong-Joong, Toots, Mart, Govindarajan, Mugunthan, Udumula, Venkata, Sakamoto, Kaori, Natchus, Michael G., Patti, Joseph, Vernachio, John, Plemper, Richard K.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Association for the Advancement of Science 2022
Materias:	Biomedicine and Life Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9232112/ https://www.ncbi.nlm.nih.gov/pubmed/35749502 http://dx.doi.org/10.1126/sciadv.abo2236

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