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HiCImpute: A Bayesian hierarchical model for identifying structural zeros and enhancing single cell Hi-C data
Single cell Hi-C techniques enable one to study cell to cell variability in chromatin interactions. However, single cell Hi-C (scHi-C) data suffer severely from sparsity, that is, the existence of excess zeros due to insufficient sequencing depth. Complicating the matter further is the fact that not...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9232133/ https://www.ncbi.nlm.nih.gov/pubmed/35696429 http://dx.doi.org/10.1371/journal.pcbi.1010129 |