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Melioidosis in the remote Katherine region of northern Australia

Melioidosis is endemic in the remote Katherine region of northern Australia. In a population with high rates of chronic disease, social inequities, and extreme remoteness, the impact of melioidosis is exacerbated by severe weather events and disproportionately affects First Nations Australians. All...

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Autores principales: Hodgetts, Kay, Kleinecke, Mariana, Woerle, Celeste, Kaestli, Mirjam, Budd, Richard, Webb, Jessica R., Ward, Linda, Mayo, Mark, Currie, Bart J., Meumann, Ella M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9232150/
https://www.ncbi.nlm.nih.gov/pubmed/35696415
http://dx.doi.org/10.1371/journal.pntd.0010486
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author Hodgetts, Kay
Kleinecke, Mariana
Woerle, Celeste
Kaestli, Mirjam
Budd, Richard
Webb, Jessica R.
Ward, Linda
Mayo, Mark
Currie, Bart J.
Meumann, Ella M.
author_facet Hodgetts, Kay
Kleinecke, Mariana
Woerle, Celeste
Kaestli, Mirjam
Budd, Richard
Webb, Jessica R.
Ward, Linda
Mayo, Mark
Currie, Bart J.
Meumann, Ella M.
author_sort Hodgetts, Kay
collection PubMed
description Melioidosis is endemic in the remote Katherine region of northern Australia. In a population with high rates of chronic disease, social inequities, and extreme remoteness, the impact of melioidosis is exacerbated by severe weather events and disproportionately affects First Nations Australians. All culture-confirmed melioidosis cases in the Katherine region of the Australian Top End between 1989–2021 were included in the study, and the clinical features and epidemiology were described. The diversity of Burkholderia pseudomallei strains in the region was investigated using genomic sequencing. From 1989–2021 there were 128 patients with melioidosis in the Katherine region. 96/128 (75%) patients were First Nations Australians, 72/128 (56%) were from a very remote region, 68/128 (53%) had diabetes, 57/128 (44%) had a history of hazardous alcohol consumption, and 11/128 (9%) died from melioidosis. There were 9 melioidosis cases attributable to the flooding of the Katherine River in January 1998; 7/9 flood-associated cases had cutaneous melioidosis, five of whom recalled an inoculating event injury sustained wading through flood waters or cleaning up after the flood. The 126 first-episode clinical B. pseudomallei isolates that underwent genomic sequencing belonged to 107 different sequence types and were highly diverse, reflecting the vast geographic area of the study region. In conclusion, melioidosis in the Katherine region disproportionately affects First Nations Australians with risk factors and is exacerbated by severe weather events. Diabetes management, public health intervention for hazardous alcohol consumption, provision of housing to address homelessness, and patient education on melioidosis prevention in First Nations languages should be prioritised.
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spelling pubmed-92321502022-06-25 Melioidosis in the remote Katherine region of northern Australia Hodgetts, Kay Kleinecke, Mariana Woerle, Celeste Kaestli, Mirjam Budd, Richard Webb, Jessica R. Ward, Linda Mayo, Mark Currie, Bart J. Meumann, Ella M. PLoS Negl Trop Dis Research Article Melioidosis is endemic in the remote Katherine region of northern Australia. In a population with high rates of chronic disease, social inequities, and extreme remoteness, the impact of melioidosis is exacerbated by severe weather events and disproportionately affects First Nations Australians. All culture-confirmed melioidosis cases in the Katherine region of the Australian Top End between 1989–2021 were included in the study, and the clinical features and epidemiology were described. The diversity of Burkholderia pseudomallei strains in the region was investigated using genomic sequencing. From 1989–2021 there were 128 patients with melioidosis in the Katherine region. 96/128 (75%) patients were First Nations Australians, 72/128 (56%) were from a very remote region, 68/128 (53%) had diabetes, 57/128 (44%) had a history of hazardous alcohol consumption, and 11/128 (9%) died from melioidosis. There were 9 melioidosis cases attributable to the flooding of the Katherine River in January 1998; 7/9 flood-associated cases had cutaneous melioidosis, five of whom recalled an inoculating event injury sustained wading through flood waters or cleaning up after the flood. The 126 first-episode clinical B. pseudomallei isolates that underwent genomic sequencing belonged to 107 different sequence types and were highly diverse, reflecting the vast geographic area of the study region. In conclusion, melioidosis in the Katherine region disproportionately affects First Nations Australians with risk factors and is exacerbated by severe weather events. Diabetes management, public health intervention for hazardous alcohol consumption, provision of housing to address homelessness, and patient education on melioidosis prevention in First Nations languages should be prioritised. Public Library of Science 2022-06-13 /pmc/articles/PMC9232150/ /pubmed/35696415 http://dx.doi.org/10.1371/journal.pntd.0010486 Text en © 2022 Hodgetts et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Hodgetts, Kay
Kleinecke, Mariana
Woerle, Celeste
Kaestli, Mirjam
Budd, Richard
Webb, Jessica R.
Ward, Linda
Mayo, Mark
Currie, Bart J.
Meumann, Ella M.
Melioidosis in the remote Katherine region of northern Australia
title Melioidosis in the remote Katherine region of northern Australia
title_full Melioidosis in the remote Katherine region of northern Australia
title_fullStr Melioidosis in the remote Katherine region of northern Australia
title_full_unstemmed Melioidosis in the remote Katherine region of northern Australia
title_short Melioidosis in the remote Katherine region of northern Australia
title_sort melioidosis in the remote katherine region of northern australia
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9232150/
https://www.ncbi.nlm.nih.gov/pubmed/35696415
http://dx.doi.org/10.1371/journal.pntd.0010486
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