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Site-specific MCM sumoylation prevents genome rearrangements by controlling origin-bound MCM

Timely completion of eukaryotic genome duplication requires coordinated DNA replication initiation at multiple origins. Replication begins with the loading of the Mini-Chromosome Maintenance (MCM) complex, proceeds by the activation of the Cdc45-MCM-GINS (CMG) helicase, and ends with CMG removal aft...

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Detalles Bibliográficos
Autores principales:	Quan, Yun, Zhang, Qian-yi, Zhou, Ann L., Wang, Yuhao, Cai, Jiaxi, Gao, Yong-qi, Zhou, Huilin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9232163/ https://www.ncbi.nlm.nih.gov/pubmed/35696436 http://dx.doi.org/10.1371/journal.pgen.1010275

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