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Glaucoma Cascade Screening in a High Risk Afro-Caribbean Haitian Population: A Pilot Study
PRÉCIS: Glaucoma cascade screening in first-degree relatives (FDRs) of young Haitian glaucoma patients had high yield for diagnosing manifest and suspected glaucoma in 30.8% of those screened despite modest participation. PURPOSE: To evaluate the outcomes of glaucoma cascade screening in FDRs (paren...
Autores principales: | , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Lippincott Williams & Wilkins
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9232278/ https://www.ncbi.nlm.nih.gov/pubmed/35131981 http://dx.doi.org/10.1097/IJG.0000000000001996 |
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author | Chang, Ta C. Celestin, Linda Hodapp, Elizabeth A. Grajewski, Alana L. Junk, Anna Rothman, Adam L. Duerr, Eric R.H. Swaminathan, Swarup S. Gedde, Steven J. Young, Terri L. Wiggs, Janey Olivier, Mildred M.G. Quintanilla, Raquel Arrieta, Esdras Savatovsky, Eleonore J. Vanner, Elizabeth A. Parrish, Richard K. |
author_facet | Chang, Ta C. Celestin, Linda Hodapp, Elizabeth A. Grajewski, Alana L. Junk, Anna Rothman, Adam L. Duerr, Eric R.H. Swaminathan, Swarup S. Gedde, Steven J. Young, Terri L. Wiggs, Janey Olivier, Mildred M.G. Quintanilla, Raquel Arrieta, Esdras Savatovsky, Eleonore J. Vanner, Elizabeth A. Parrish, Richard K. |
author_sort | Chang, Ta C. |
collection | PubMed |
description | PRÉCIS: Glaucoma cascade screening in first-degree relatives (FDRs) of young Haitian glaucoma patients had high yield for diagnosing manifest and suspected glaucoma in 30.8% of those screened despite modest participation. PURPOSE: To evaluate the outcomes of glaucoma cascade screening in FDRs (parents, siblings, and offspring) of Haitian juvenile open-angle glaucoma (JOAG) patients. PATIENTS AND METHODS: Consecutive index patients (Haitians with JOAG) were identified, and the number/type of FDRs residing in South Florida were recorded. These FDRs were invited for free glaucoma screening, which included a comprehensive ophthalmic exam, gonioscopy, automated visual field testing and optical coherence tomographic analysis of the retinal nerve fiber layers. FDR characteristics and clinical findings from screening are reported. RESULTS: A total of 77 FDRs were invited, 26 (33.8%) agreed to undergo screening (18 females, 9 males), which revealed 2 (7.7%) with manifest glaucoma (mean age 77.5 y; one of whom was previously unaware of his glaucoma diagnosis), 6 (23.1%) with suspected glaucoma (mean age 29.8±18.3 y), and 18 (69.2%) without manifest or suspected glaucoma (mean age 37.2±21.8 y). Siblings of index patients were least likely to participate in cascade glaucoma screening when compared with index patients’ parents or offspring. FDR eyes with manifest glaucoma had significantly worse best-corrected visual acuities, higher intraocular pressures, thinner central corneal thicknesses, and thinner circumferential papillary retinal nerve fiber layer thicknesses than those without glaucoma. CONCLUSION: Glaucoma cascade screening of Haitian JOAG patients’ FDRs revealed that 30.8% had suspected or manifest glaucoma. Future efforts centered on provider-initiated recruitment and improving public glaucoma awareness and education may increase screening participation. |
format | Online Article Text |
id | pubmed-9232278 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Lippincott Williams & Wilkins |
record_format | MEDLINE/PubMed |
spelling | pubmed-92322782022-07-01 Glaucoma Cascade Screening in a High Risk Afro-Caribbean Haitian Population: A Pilot Study Chang, Ta C. Celestin, Linda Hodapp, Elizabeth A. Grajewski, Alana L. Junk, Anna Rothman, Adam L. Duerr, Eric R.H. Swaminathan, Swarup S. Gedde, Steven J. Young, Terri L. Wiggs, Janey Olivier, Mildred M.G. Quintanilla, Raquel Arrieta, Esdras Savatovsky, Eleonore J. Vanner, Elizabeth A. Parrish, Richard K. J Glaucoma New Glaucoma Insights: Original Studies PRÉCIS: Glaucoma cascade screening in first-degree relatives (FDRs) of young Haitian glaucoma patients had high yield for diagnosing manifest and suspected glaucoma in 30.8% of those screened despite modest participation. PURPOSE: To evaluate the outcomes of glaucoma cascade screening in FDRs (parents, siblings, and offspring) of Haitian juvenile open-angle glaucoma (JOAG) patients. PATIENTS AND METHODS: Consecutive index patients (Haitians with JOAG) were identified, and the number/type of FDRs residing in South Florida were recorded. These FDRs were invited for free glaucoma screening, which included a comprehensive ophthalmic exam, gonioscopy, automated visual field testing and optical coherence tomographic analysis of the retinal nerve fiber layers. FDR characteristics and clinical findings from screening are reported. RESULTS: A total of 77 FDRs were invited, 26 (33.8%) agreed to undergo screening (18 females, 9 males), which revealed 2 (7.7%) with manifest glaucoma (mean age 77.5 y; one of whom was previously unaware of his glaucoma diagnosis), 6 (23.1%) with suspected glaucoma (mean age 29.8±18.3 y), and 18 (69.2%) without manifest or suspected glaucoma (mean age 37.2±21.8 y). Siblings of index patients were least likely to participate in cascade glaucoma screening when compared with index patients’ parents or offspring. FDR eyes with manifest glaucoma had significantly worse best-corrected visual acuities, higher intraocular pressures, thinner central corneal thicknesses, and thinner circumferential papillary retinal nerve fiber layer thicknesses than those without glaucoma. CONCLUSION: Glaucoma cascade screening of Haitian JOAG patients’ FDRs revealed that 30.8% had suspected or manifest glaucoma. Future efforts centered on provider-initiated recruitment and improving public glaucoma awareness and education may increase screening participation. Lippincott Williams & Wilkins 2022-07 2022-02-08 /pmc/articles/PMC9232278/ /pubmed/35131981 http://dx.doi.org/10.1097/IJG.0000000000001996 Text en Copyright © 2022 The Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (https://creativecommons.org/licenses/by-nc-nd/4.0/) (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) |
spellingShingle | New Glaucoma Insights: Original Studies Chang, Ta C. Celestin, Linda Hodapp, Elizabeth A. Grajewski, Alana L. Junk, Anna Rothman, Adam L. Duerr, Eric R.H. Swaminathan, Swarup S. Gedde, Steven J. Young, Terri L. Wiggs, Janey Olivier, Mildred M.G. Quintanilla, Raquel Arrieta, Esdras Savatovsky, Eleonore J. Vanner, Elizabeth A. Parrish, Richard K. Glaucoma Cascade Screening in a High Risk Afro-Caribbean Haitian Population: A Pilot Study |
title | Glaucoma Cascade Screening in a High Risk Afro-Caribbean Haitian Population: A Pilot Study |
title_full | Glaucoma Cascade Screening in a High Risk Afro-Caribbean Haitian Population: A Pilot Study |
title_fullStr | Glaucoma Cascade Screening in a High Risk Afro-Caribbean Haitian Population: A Pilot Study |
title_full_unstemmed | Glaucoma Cascade Screening in a High Risk Afro-Caribbean Haitian Population: A Pilot Study |
title_short | Glaucoma Cascade Screening in a High Risk Afro-Caribbean Haitian Population: A Pilot Study |
title_sort | glaucoma cascade screening in a high risk afro-caribbean haitian population: a pilot study |
topic | New Glaucoma Insights: Original Studies |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9232278/ https://www.ncbi.nlm.nih.gov/pubmed/35131981 http://dx.doi.org/10.1097/IJG.0000000000001996 |
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