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Neuroprotective and Anti-inflammatory Effects of Pioglitazone on Traumatic Brain Injury
Traumatic brain injury (TBI) is still a major cause of concern for public health, and out of all the trauma-related injuries, it makes the highest contribution to death and disability worldwide. Patients of TBI continue to suffer from brain injury through an intricate flow of primary and secondary i...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9232315/ https://www.ncbi.nlm.nih.gov/pubmed/35757108 http://dx.doi.org/10.1155/2022/9860855 |
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author | Zamanian, Mohammad Yassin Taheri, Niloofar Opulencia, Maria Jade Catalan Bokov, Dmitry Olegovich Abdullaev, Sharif Y. Gholamrezapour, Mohammadreza Heidari, Mahsa Bazmandegan, Gholamreza |
author_facet | Zamanian, Mohammad Yassin Taheri, Niloofar Opulencia, Maria Jade Catalan Bokov, Dmitry Olegovich Abdullaev, Sharif Y. Gholamrezapour, Mohammadreza Heidari, Mahsa Bazmandegan, Gholamreza |
author_sort | Zamanian, Mohammad Yassin |
collection | PubMed |
description | Traumatic brain injury (TBI) is still a major cause of concern for public health, and out of all the trauma-related injuries, it makes the highest contribution to death and disability worldwide. Patients of TBI continue to suffer from brain injury through an intricate flow of primary and secondary injury events. However, when treatment is provided in a timely manner, there is a significant window of opportunity to avoid a few of the serious effects. Pioglitazone (PG), which has a neuroprotective impact and can decrease inflammation after TBI, activates peroxisome proliferator-activated receptor-gamma (PPARγ). The objective of the study is to examine the existing literature to assess the neuroprotective and anti-inflammatory impact of PG in TBI. It also discusses the part played by microglia and cytokines in TBI. According to the findings of this study, PG has the ability to enhance neurobehavior, decrease brain edema and neuronal injury following TBI. To achieve the protective impact of PG the following was required: (1) stimulating PPARγ; (2) decreasing oxidative stress; (3) decreasing nuclear factor kappa B (NF-κB), interleukin 6 (IL-6), interleukin-1β (IL-1β), cyclooxygenase-2 (COX-2), and C-C motif chemokine ligand 20 (CCL20) expression; (4) limiting the increase in the number of activated microglia; and (5) reducing mitochondrial dysfunction. The findings indicate that when PIG is used clinically, it may serve as a neuroprotective anti-inflammatory approach in TBI. |
format | Online Article Text |
id | pubmed-9232315 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-92323152022-06-25 Neuroprotective and Anti-inflammatory Effects of Pioglitazone on Traumatic Brain Injury Zamanian, Mohammad Yassin Taheri, Niloofar Opulencia, Maria Jade Catalan Bokov, Dmitry Olegovich Abdullaev, Sharif Y. Gholamrezapour, Mohammadreza Heidari, Mahsa Bazmandegan, Gholamreza Mediators Inflamm Review Article Traumatic brain injury (TBI) is still a major cause of concern for public health, and out of all the trauma-related injuries, it makes the highest contribution to death and disability worldwide. Patients of TBI continue to suffer from brain injury through an intricate flow of primary and secondary injury events. However, when treatment is provided in a timely manner, there is a significant window of opportunity to avoid a few of the serious effects. Pioglitazone (PG), which has a neuroprotective impact and can decrease inflammation after TBI, activates peroxisome proliferator-activated receptor-gamma (PPARγ). The objective of the study is to examine the existing literature to assess the neuroprotective and anti-inflammatory impact of PG in TBI. It also discusses the part played by microglia and cytokines in TBI. According to the findings of this study, PG has the ability to enhance neurobehavior, decrease brain edema and neuronal injury following TBI. To achieve the protective impact of PG the following was required: (1) stimulating PPARγ; (2) decreasing oxidative stress; (3) decreasing nuclear factor kappa B (NF-κB), interleukin 6 (IL-6), interleukin-1β (IL-1β), cyclooxygenase-2 (COX-2), and C-C motif chemokine ligand 20 (CCL20) expression; (4) limiting the increase in the number of activated microglia; and (5) reducing mitochondrial dysfunction. The findings indicate that when PIG is used clinically, it may serve as a neuroprotective anti-inflammatory approach in TBI. Hindawi 2022-06-17 /pmc/articles/PMC9232315/ /pubmed/35757108 http://dx.doi.org/10.1155/2022/9860855 Text en Copyright © 2022 Mohammad Yassin Zamanian et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Zamanian, Mohammad Yassin Taheri, Niloofar Opulencia, Maria Jade Catalan Bokov, Dmitry Olegovich Abdullaev, Sharif Y. Gholamrezapour, Mohammadreza Heidari, Mahsa Bazmandegan, Gholamreza Neuroprotective and Anti-inflammatory Effects of Pioglitazone on Traumatic Brain Injury |
title | Neuroprotective and Anti-inflammatory Effects of Pioglitazone on Traumatic Brain Injury |
title_full | Neuroprotective and Anti-inflammatory Effects of Pioglitazone on Traumatic Brain Injury |
title_fullStr | Neuroprotective and Anti-inflammatory Effects of Pioglitazone on Traumatic Brain Injury |
title_full_unstemmed | Neuroprotective and Anti-inflammatory Effects of Pioglitazone on Traumatic Brain Injury |
title_short | Neuroprotective and Anti-inflammatory Effects of Pioglitazone on Traumatic Brain Injury |
title_sort | neuroprotective and anti-inflammatory effects of pioglitazone on traumatic brain injury |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9232315/ https://www.ncbi.nlm.nih.gov/pubmed/35757108 http://dx.doi.org/10.1155/2022/9860855 |
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