Clinical Effect of Butylphthalide Combined with Rt-PA Intravenous Thrombolysis in the Treatment of Acute Cerebral Infarction

OBJECTIVE: To assess the clinical effect of butylphthalide combined with rt-PA intravenous thrombolysis in the treatment of acute cerebral infarction (ACI). METHODS: Totally, 312 acute cerebral infarction patients were included in this research. Those in the group for experiment received butylphthal...

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Autores principales: Zhou, Xiangchen, Yang, Jundong, Liu, Lihua, Zhu, Yingying
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9232321/
https://www.ncbi.nlm.nih.gov/pubmed/35756870
http://dx.doi.org/10.1155/2022/9215685
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author Zhou, Xiangchen
Yang, Jundong
Liu, Lihua
Zhu, Yingying
author_facet Zhou, Xiangchen
Yang, Jundong
Liu, Lihua
Zhu, Yingying
author_sort Zhou, Xiangchen
collection PubMed
description OBJECTIVE: To assess the clinical effect of butylphthalide combined with rt-PA intravenous thrombolysis in the treatment of acute cerebral infarction (ACI). METHODS: Totally, 312 acute cerebral infarction patients were included in this research. Those in the group for experiment received butylphthalide (25 mg QD) combined with rt-PA intravenous thrombolysis (0.9 mg/kg QD), while the control group received rt-PA intravenous (P < 0.05). Moreover, NIHSS (NIH Stroke Scale/Score) and Barthel index scores in the two groups improved, NIHSS score had ameliorated, and Barthel index score was higher than that in the reference group (P < 0.05). CONCLUSION: The combination of butylphthalide and recombination plasminogen activator alteplase (rt-PA) intravenous thrombolysis has a significant clinical effect in the treatment of acute cerebral infarction. It can alleviate the inflammatory symptoms, accelerate the recovery of neurological function, and improve the ability of daily living.
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spelling pubmed-92323212022-06-25 Clinical Effect of Butylphthalide Combined with Rt-PA Intravenous Thrombolysis in the Treatment of Acute Cerebral Infarction Zhou, Xiangchen Yang, Jundong Liu, Lihua Zhu, Yingying Appl Bionics Biomech Research Article OBJECTIVE: To assess the clinical effect of butylphthalide combined with rt-PA intravenous thrombolysis in the treatment of acute cerebral infarction (ACI). METHODS: Totally, 312 acute cerebral infarction patients were included in this research. Those in the group for experiment received butylphthalide (25 mg QD) combined with rt-PA intravenous thrombolysis (0.9 mg/kg QD), while the control group received rt-PA intravenous (P < 0.05). Moreover, NIHSS (NIH Stroke Scale/Score) and Barthel index scores in the two groups improved, NIHSS score had ameliorated, and Barthel index score was higher than that in the reference group (P < 0.05). CONCLUSION: The combination of butylphthalide and recombination plasminogen activator alteplase (rt-PA) intravenous thrombolysis has a significant clinical effect in the treatment of acute cerebral infarction. It can alleviate the inflammatory symptoms, accelerate the recovery of neurological function, and improve the ability of daily living. Hindawi 2022-06-17 /pmc/articles/PMC9232321/ /pubmed/35756870 http://dx.doi.org/10.1155/2022/9215685 Text en Copyright © 2022 Xiangchen Zhou et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Zhou, Xiangchen
Yang, Jundong
Liu, Lihua
Zhu, Yingying
Clinical Effect of Butylphthalide Combined with Rt-PA Intravenous Thrombolysis in the Treatment of Acute Cerebral Infarction
title Clinical Effect of Butylphthalide Combined with Rt-PA Intravenous Thrombolysis in the Treatment of Acute Cerebral Infarction
title_full Clinical Effect of Butylphthalide Combined with Rt-PA Intravenous Thrombolysis in the Treatment of Acute Cerebral Infarction
title_fullStr Clinical Effect of Butylphthalide Combined with Rt-PA Intravenous Thrombolysis in the Treatment of Acute Cerebral Infarction
title_full_unstemmed Clinical Effect of Butylphthalide Combined with Rt-PA Intravenous Thrombolysis in the Treatment of Acute Cerebral Infarction
title_short Clinical Effect of Butylphthalide Combined with Rt-PA Intravenous Thrombolysis in the Treatment of Acute Cerebral Infarction
title_sort clinical effect of butylphthalide combined with rt-pa intravenous thrombolysis in the treatment of acute cerebral infarction
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9232321/
https://www.ncbi.nlm.nih.gov/pubmed/35756870
http://dx.doi.org/10.1155/2022/9215685
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AT liulihua clinicaleffectofbutylphthalidecombinedwithrtpaintravenousthrombolysisinthetreatmentofacutecerebralinfarction
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