DNA damage-induced transcription stress triggers the genome-wide degradation of promoter-bound Pol II

The precise regulation of RNA Polymerase II (Pol II) transcription after genotoxic stress is crucial for proper execution of the DNA damage-induced stress response. While stalling of Pol II on transcription-blocking lesions (TBLs) blocks transcript elongation and initiates DNA repair in cis, TBLs ad...

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Detalles Bibliográficos
Autores principales: Steurer, Barbara, Janssens, Roel C., Geijer, Marit E., Aprile-Garcia, Fernando, Geverts, Bart, Theil, Arjan F., Hummel, Barbara, van Royen, Martin E., Evers, Bastiaan, Bernards, René, Houtsmuller, Adriaan B., Sawarkar, Ritwick, Marteijn, Jurgen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9232492/
https://www.ncbi.nlm.nih.gov/pubmed/35750669
http://dx.doi.org/10.1038/s41467-022-31329-w

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