Cell surface glycan engineering reveals that matriglycan alone can recapitulate dystroglycan binding and function

α-Dystroglycan (α-DG) is uniquely modified on O-mannose sites by a repeating disaccharide (-Xylα1,3-GlcAβ1,3-)(n) termed matriglycan, which is a receptor for laminin-G domain-containing proteins and employed by old-world arenaviruses for infection. Using chemoenzymatically synthesized matriglycans p...

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Detalles Bibliográficos
Autores principales: Sheikh, M. Osman, Capicciotti, Chantelle J., Liu, Lin, Praissman, Jeremy, Ding, Dahai, Mead, Daniel G., Brindley, Melinda A., Willer, Tobias, Campbell, Kevin P., Moremen, Kelley W., Wells, Lance, Boons, Geert-Jan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9232514/
https://www.ncbi.nlm.nih.gov/pubmed/35750689
http://dx.doi.org/10.1038/s41467-022-31205-7

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