Critical contributions of pre-S1 shoulder and distal TRP box in DAG-activated TRPC6 channel by PIP(2) regulation

Phosphatidylinositol 4,5-bisphosphate (PI(4,5)P(2) or PIP(2)) regulates the activities of numerous membrane proteins, including diacylglycerol(DAG)-activated TRPC3/6/7 channels. Although PIP(2) binding is known to support DAG-activated TRP channel activity, its binding site remains unknown. We scree...

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Detalles Bibliográficos
Autores principales: Mori, Masayuki X., Okada, Ryo, Sakaguchi, Reiko, Hase, Hideharu, Imai, Yuko, Polat, Onur K., Itoh, Satoru G., Okumura, Hisashi, Mori, Yasuo, Okamura, Yasushi, Inoue, Ryuji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9232555/
https://www.ncbi.nlm.nih.gov/pubmed/35750783
http://dx.doi.org/10.1038/s41598-022-14766-x

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