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Divergent encoding of active avoidance behavior in corticostriatal and corticolimbic projections

Active avoidance behavior, in which an animal performs an action to avoid a stressor, is crucial for survival and may provide insight into avoidance behaviors seen in anxiety disorders. Active avoidance requires the dorsomedial prefrontal cortex (dmPFC), which is thought to regulate avoidance via do...

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Autores principales: Kajs, Bridget L., Loewke, Adrienne C., Dorsch, Jeffrey M., Vinson, Leah T., Gunaydin, Lisa A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9232563/
https://www.ncbi.nlm.nih.gov/pubmed/35750718
http://dx.doi.org/10.1038/s41598-022-14930-3
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author Kajs, Bridget L.
Loewke, Adrienne C.
Dorsch, Jeffrey M.
Vinson, Leah T.
Gunaydin, Lisa A.
author_facet Kajs, Bridget L.
Loewke, Adrienne C.
Dorsch, Jeffrey M.
Vinson, Leah T.
Gunaydin, Lisa A.
author_sort Kajs, Bridget L.
collection PubMed
description Active avoidance behavior, in which an animal performs an action to avoid a stressor, is crucial for survival and may provide insight into avoidance behaviors seen in anxiety disorders. Active avoidance requires the dorsomedial prefrontal cortex (dmPFC), which is thought to regulate avoidance via downstream projections to the striatum and amygdala. However, the endogenous activity of dmPFC projections during active avoidance learning has never been recorded. Here we utilized fiber photometry to record from the dmPFC and its axonal projections to the dorsomedial striatum (DMS) and the basolateral amygdala (BLA) during active avoidance learning in both male and female mice. We examined neural activity during conditioned stimulus (CS) presentations and during clinically relevant behaviors such as active avoidance or cued freezing. Both prefrontal projections showed learning-related increases in activity during CS onset throughout active avoidance training. The dmPFC as a whole showed increased and decreased patterns of activity during avoidance and cued freezing, respectively. Finally, dmPFC-DMS and dmPFC-BLA projections show divergent encoding of active avoidance behavior, with the dmPFC-DMS projection showing increased activity and the dmPFC-BLA projection showing decreased activity during active avoidance. Our results demonstrate task-relevant encoding of active avoidance in projection-specific dmPFC subpopulations that play distinct but complementary roles in active avoidance learning.
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spelling pubmed-92325632022-06-26 Divergent encoding of active avoidance behavior in corticostriatal and corticolimbic projections Kajs, Bridget L. Loewke, Adrienne C. Dorsch, Jeffrey M. Vinson, Leah T. Gunaydin, Lisa A. Sci Rep Article Active avoidance behavior, in which an animal performs an action to avoid a stressor, is crucial for survival and may provide insight into avoidance behaviors seen in anxiety disorders. Active avoidance requires the dorsomedial prefrontal cortex (dmPFC), which is thought to regulate avoidance via downstream projections to the striatum and amygdala. However, the endogenous activity of dmPFC projections during active avoidance learning has never been recorded. Here we utilized fiber photometry to record from the dmPFC and its axonal projections to the dorsomedial striatum (DMS) and the basolateral amygdala (BLA) during active avoidance learning in both male and female mice. We examined neural activity during conditioned stimulus (CS) presentations and during clinically relevant behaviors such as active avoidance or cued freezing. Both prefrontal projections showed learning-related increases in activity during CS onset throughout active avoidance training. The dmPFC as a whole showed increased and decreased patterns of activity during avoidance and cued freezing, respectively. Finally, dmPFC-DMS and dmPFC-BLA projections show divergent encoding of active avoidance behavior, with the dmPFC-DMS projection showing increased activity and the dmPFC-BLA projection showing decreased activity during active avoidance. Our results demonstrate task-relevant encoding of active avoidance in projection-specific dmPFC subpopulations that play distinct but complementary roles in active avoidance learning. Nature Publishing Group UK 2022-06-24 /pmc/articles/PMC9232563/ /pubmed/35750718 http://dx.doi.org/10.1038/s41598-022-14930-3 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Kajs, Bridget L.
Loewke, Adrienne C.
Dorsch, Jeffrey M.
Vinson, Leah T.
Gunaydin, Lisa A.
Divergent encoding of active avoidance behavior in corticostriatal and corticolimbic projections
title Divergent encoding of active avoidance behavior in corticostriatal and corticolimbic projections
title_full Divergent encoding of active avoidance behavior in corticostriatal and corticolimbic projections
title_fullStr Divergent encoding of active avoidance behavior in corticostriatal and corticolimbic projections
title_full_unstemmed Divergent encoding of active avoidance behavior in corticostriatal and corticolimbic projections
title_short Divergent encoding of active avoidance behavior in corticostriatal and corticolimbic projections
title_sort divergent encoding of active avoidance behavior in corticostriatal and corticolimbic projections
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9232563/
https://www.ncbi.nlm.nih.gov/pubmed/35750718
http://dx.doi.org/10.1038/s41598-022-14930-3
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