Effect of gut microbiota in the colorectal cancer and potential target therapy

The symbiotic interaction between gut microbiota and the digestive tract is an important factor in maintaining the intestinal environment balance. Colorectal cancer (CRC) is a complex disease involving the interaction between tumour cells and a large number of microorganisms. The microbiota is invol...

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Detalles Bibliográficos
Autores principales: Li, Junchuan, Zhu, Yuzhou, Yang, Lie, Wang, Ziqiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9232688/
https://www.ncbi.nlm.nih.gov/pubmed/35749000
http://dx.doi.org/10.1007/s12672-022-00517-x
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author Li, Junchuan
Zhu, Yuzhou
Yang, Lie
Wang, Ziqiang
author_facet Li, Junchuan
Zhu, Yuzhou
Yang, Lie
Wang, Ziqiang
author_sort Li, Junchuan
collection PubMed
description The symbiotic interaction between gut microbiota and the digestive tract is an important factor in maintaining the intestinal environment balance. Colorectal cancer (CRC) is a complex disease involving the interaction between tumour cells and a large number of microorganisms. The microbiota is involved in the occurrence, development and prognosis of colorectal cancer. Several microbiota species have been studied, such as Fusobacterium nucleatum (F. nucleatum), Enterotoxigenic Bacteroides fragilis (ETBF), Streptococcus bovis (S. bovis), Lactobacillus, and Bifidobacterium. Studies about the interaction between microbiota and CRC were retrieved from Embase, PubMed, Ovid and Web of Science up to 21 Oct 2021. This review expounded on the effect of microbiota on CRC, especially the dysregulation of bacteria and carcinogenicity. The methods of gut microbiota modifications representing novel prognostic markers and innovative therapeutic strategies were also described.
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spelling pubmed-92326882022-06-26 Effect of gut microbiota in the colorectal cancer and potential target therapy Li, Junchuan Zhu, Yuzhou Yang, Lie Wang, Ziqiang Discov Oncol Review The symbiotic interaction between gut microbiota and the digestive tract is an important factor in maintaining the intestinal environment balance. Colorectal cancer (CRC) is a complex disease involving the interaction between tumour cells and a large number of microorganisms. The microbiota is involved in the occurrence, development and prognosis of colorectal cancer. Several microbiota species have been studied, such as Fusobacterium nucleatum (F. nucleatum), Enterotoxigenic Bacteroides fragilis (ETBF), Streptococcus bovis (S. bovis), Lactobacillus, and Bifidobacterium. Studies about the interaction between microbiota and CRC were retrieved from Embase, PubMed, Ovid and Web of Science up to 21 Oct 2021. This review expounded on the effect of microbiota on CRC, especially the dysregulation of bacteria and carcinogenicity. The methods of gut microbiota modifications representing novel prognostic markers and innovative therapeutic strategies were also described. Springer US 2022-06-24 /pmc/articles/PMC9232688/ /pubmed/35749000 http://dx.doi.org/10.1007/s12672-022-00517-x Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Review
Li, Junchuan
Zhu, Yuzhou
Yang, Lie
Wang, Ziqiang
Effect of gut microbiota in the colorectal cancer and potential target therapy
title Effect of gut microbiota in the colorectal cancer and potential target therapy
title_full Effect of gut microbiota in the colorectal cancer and potential target therapy
title_fullStr Effect of gut microbiota in the colorectal cancer and potential target therapy
title_full_unstemmed Effect of gut microbiota in the colorectal cancer and potential target therapy
title_short Effect of gut microbiota in the colorectal cancer and potential target therapy
title_sort effect of gut microbiota in the colorectal cancer and potential target therapy
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9232688/
https://www.ncbi.nlm.nih.gov/pubmed/35749000
http://dx.doi.org/10.1007/s12672-022-00517-x
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