Cancer-cell-secreted Extracellular Vesicles Suppress Insulin Secretion through miR-122 to Impair Systemic Glucose Homeostasis and Contribute to Tumour Growth

Epidemiological studies demonstrate an association between breast cancer (BC) and systemic dysregulation of glucose metabolism. However, how BC influences glucose homeostasis remains unknown. We show that BC-derived extracellular vesicles (EVs) suppress pancreatic insulin secretion to impair glucose...

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Detalles Bibliográficos
Autores principales: Cao, Minghui, Isaac, Roi, Yan, Wei, Ruan, Xianhui, Jiang, Li, Wan, Yuhao, Wang, Jessica, Wang, Emily, Caron, Christine, Neben, Steven, Drygin, Denis, Pizzo, Donald P., Wu, Xiwei, Liu, Xuxiang, Chin, Andrew R., Fong, Miranda Y., Gao, Ziting, Guo, Kaizhu, Fadare, Oluwole, Schwab, Richard B., Yuan, Yuan, Yost, Susan E., Mortimer, Joanne, Zhong, Wenwan, Ying, Wei, Bui, Jack D., Sears, Dorothy D., Olefsky, Jerrold M., Wang, Shizhen Emily
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9233030/
https://www.ncbi.nlm.nih.gov/pubmed/35637408
http://dx.doi.org/10.1038/s41556-022-00919-7

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