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Intermediate- and long-term associations between air pollution and ambient temperature and glycated hemoglobin levels in women of child bearing age

BACKGROUND: Air pollution has been linked to obesity while higher ambient temperatures typically reduce metabolic demand in a compensatory manner. Both relationships may impact glucose metabolism, thus we examined the association between intermediate- and long-term exposure to fine particulate matte...

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Autores principales: He, Mike Z., Kloog, Itai, Just, Allan C., Gutéerrez-Avila, Iván, Colicino, Elena, Téllez-Rojo, Martha M., Pizano-Zárate, María Luisa, Tamayo-Ortiz, Marcela, Cantoral, Alejandra, Soria-Contreras, Diana C., Baccarelli, Andrea A., Wright, Robert O., Yitshak-Sade, Maayan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9233109/
https://www.ncbi.nlm.nih.gov/pubmed/35597113
http://dx.doi.org/10.1016/j.envint.2022.107298
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author He, Mike Z.
Kloog, Itai
Just, Allan C.
Gutéerrez-Avila, Iván
Colicino, Elena
Téllez-Rojo, Martha M.
Pizano-Zárate, María Luisa
Tamayo-Ortiz, Marcela
Cantoral, Alejandra
Soria-Contreras, Diana C.
Baccarelli, Andrea A.
Wright, Robert O.
Yitshak-Sade, Maayan
author_facet He, Mike Z.
Kloog, Itai
Just, Allan C.
Gutéerrez-Avila, Iván
Colicino, Elena
Téllez-Rojo, Martha M.
Pizano-Zárate, María Luisa
Tamayo-Ortiz, Marcela
Cantoral, Alejandra
Soria-Contreras, Diana C.
Baccarelli, Andrea A.
Wright, Robert O.
Yitshak-Sade, Maayan
author_sort He, Mike Z.
collection PubMed
description BACKGROUND: Air pollution has been linked to obesity while higher ambient temperatures typically reduce metabolic demand in a compensatory manner. Both relationships may impact glucose metabolism, thus we examined the association between intermediate- and long-term exposure to fine particulate matter (PM(2.5)) and ambient temperature and glycated hemoglobin (HbA1c), a longer-term marker of glucose control. METHODS: We assessed 3-month, 6-month, and 12-month average air pollution and ambient temperature at 1-km(2) spatial resolution via satellite remote sensing models (2013–2019), and assessed HbA1c at four, six, and eight years postpartum in women enrolled in the Programming Research in Obesity, Growth, Environment and Social Stressors (PROGRESS) cohort based in Mexico City. PM(2.5) and ambient temperature were matched to participants’ addresses and confirmed by GPS tracker. Using linear mixed-effects models, we examined the association between 3-month, 6-month, and 12-month average PM(2.5) and ambient temperature with repeated log-transformed HbA1c values. All models included a random intercept for each woman and were adjusted for calendar year, season, and individual-level confounders (age, marital status, smoking, alcohol consumption level, and education level). RESULTS: We analyzed 1,265 HbA1c measurements of 484 women. Per 1 μg/m(3) increase in 3-month and 6-month PM(2.5), HbA1c levels increased by 0.28% (95% confidence interval (95 %CI): 0.14, 0.42%) and 0.28% (95 %CI: 0.04, 0.52%) respectively. No association was seen for 12-month average PM(2.5). Per 1 °C increase in ambient temperature, HbA1c levels decreased by 0.63% (95 %CI: −1.06, −0.21%) and 0.61% (95 %CI: −1.08, −0.13%), while the 12-month average again is not associated with HbA1c. CONCLUSIONS: Intermediate-term exposure to PM(2.5) and ambient temperature are associated with opposing changes in HbA1c levels, in this region of high PM(2.5) and moderate temperature fluctuation. These effects, measurable in mid-adult life, may portend future risk of type 2 diabetes and possible heart disease.
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spelling pubmed-92331092022-07-01 Intermediate- and long-term associations between air pollution and ambient temperature and glycated hemoglobin levels in women of child bearing age He, Mike Z. Kloog, Itai Just, Allan C. Gutéerrez-Avila, Iván Colicino, Elena Téllez-Rojo, Martha M. Pizano-Zárate, María Luisa Tamayo-Ortiz, Marcela Cantoral, Alejandra Soria-Contreras, Diana C. Baccarelli, Andrea A. Wright, Robert O. Yitshak-Sade, Maayan Environ Int Article BACKGROUND: Air pollution has been linked to obesity while higher ambient temperatures typically reduce metabolic demand in a compensatory manner. Both relationships may impact glucose metabolism, thus we examined the association between intermediate- and long-term exposure to fine particulate matter (PM(2.5)) and ambient temperature and glycated hemoglobin (HbA1c), a longer-term marker of glucose control. METHODS: We assessed 3-month, 6-month, and 12-month average air pollution and ambient temperature at 1-km(2) spatial resolution via satellite remote sensing models (2013–2019), and assessed HbA1c at four, six, and eight years postpartum in women enrolled in the Programming Research in Obesity, Growth, Environment and Social Stressors (PROGRESS) cohort based in Mexico City. PM(2.5) and ambient temperature were matched to participants’ addresses and confirmed by GPS tracker. Using linear mixed-effects models, we examined the association between 3-month, 6-month, and 12-month average PM(2.5) and ambient temperature with repeated log-transformed HbA1c values. All models included a random intercept for each woman and were adjusted for calendar year, season, and individual-level confounders (age, marital status, smoking, alcohol consumption level, and education level). RESULTS: We analyzed 1,265 HbA1c measurements of 484 women. Per 1 μg/m(3) increase in 3-month and 6-month PM(2.5), HbA1c levels increased by 0.28% (95% confidence interval (95 %CI): 0.14, 0.42%) and 0.28% (95 %CI: 0.04, 0.52%) respectively. No association was seen for 12-month average PM(2.5). Per 1 °C increase in ambient temperature, HbA1c levels decreased by 0.63% (95 %CI: −1.06, −0.21%) and 0.61% (95 %CI: −1.08, −0.13%), while the 12-month average again is not associated with HbA1c. CONCLUSIONS: Intermediate-term exposure to PM(2.5) and ambient temperature are associated with opposing changes in HbA1c levels, in this region of high PM(2.5) and moderate temperature fluctuation. These effects, measurable in mid-adult life, may portend future risk of type 2 diabetes and possible heart disease. 2022-07 2022-05-14 /pmc/articles/PMC9233109/ /pubmed/35597113 http://dx.doi.org/10.1016/j.envint.2022.107298 Text en https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) ).
spellingShingle Article
He, Mike Z.
Kloog, Itai
Just, Allan C.
Gutéerrez-Avila, Iván
Colicino, Elena
Téllez-Rojo, Martha M.
Pizano-Zárate, María Luisa
Tamayo-Ortiz, Marcela
Cantoral, Alejandra
Soria-Contreras, Diana C.
Baccarelli, Andrea A.
Wright, Robert O.
Yitshak-Sade, Maayan
Intermediate- and long-term associations between air pollution and ambient temperature and glycated hemoglobin levels in women of child bearing age
title Intermediate- and long-term associations between air pollution and ambient temperature and glycated hemoglobin levels in women of child bearing age
title_full Intermediate- and long-term associations between air pollution and ambient temperature and glycated hemoglobin levels in women of child bearing age
title_fullStr Intermediate- and long-term associations between air pollution and ambient temperature and glycated hemoglobin levels in women of child bearing age
title_full_unstemmed Intermediate- and long-term associations between air pollution and ambient temperature and glycated hemoglobin levels in women of child bearing age
title_short Intermediate- and long-term associations between air pollution and ambient temperature and glycated hemoglobin levels in women of child bearing age
title_sort intermediate- and long-term associations between air pollution and ambient temperature and glycated hemoglobin levels in women of child bearing age
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9233109/
https://www.ncbi.nlm.nih.gov/pubmed/35597113
http://dx.doi.org/10.1016/j.envint.2022.107298
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