Cargando…
Imaging perivascular space structure and function using brain MRI
In this article, we provide an overview of current neuroimaging methods for studying perivascular spaces (PVS) in humans using brain MRI. In recent years, an increasing number of studies highlighted the role of PVS in cerebrospinal/interstial fluid circulation and clearance of cerebral waste product...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9233116/ https://www.ncbi.nlm.nih.gov/pubmed/35609770 http://dx.doi.org/10.1016/j.neuroimage.2022.119329 |
_version_ | 1784735696193323008 |
---|---|
author | Barisano, Giuseppe Lynch, Kirsten M. Sibilia, Francesca Lan, Haoyu Shih, Nien-Chu Sepehrband, Farshid Choupan, Jeiran |
author_facet | Barisano, Giuseppe Lynch, Kirsten M. Sibilia, Francesca Lan, Haoyu Shih, Nien-Chu Sepehrband, Farshid Choupan, Jeiran |
author_sort | Barisano, Giuseppe |
collection | PubMed |
description | In this article, we provide an overview of current neuroimaging methods for studying perivascular spaces (PVS) in humans using brain MRI. In recent years, an increasing number of studies highlighted the role of PVS in cerebrospinal/interstial fluid circulation and clearance of cerebral waste products and their association with neurological diseases. Novel strategies and techniques have been introduced to improve the quantification of PVS and to investigate their function and morphological features in physiological and pathological conditions. After a brief introduction on the anatomy and physiology of PVS, we examine the latest technological developments to quantitatively analyze the structure and function of PVS in humans with MRI. We describe the applications, advantages, and limitations of these methods, providing guidance and suggestions on the acquisition protocols and analysis techniques that can be applied to study PVS in vivo. Finally, we review the human neuroimaging studies on PVS across the normative lifespan and in the context of neurological disorders. |
format | Online Article Text |
id | pubmed-9233116 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
record_format | MEDLINE/PubMed |
spelling | pubmed-92331162022-08-15 Imaging perivascular space structure and function using brain MRI Barisano, Giuseppe Lynch, Kirsten M. Sibilia, Francesca Lan, Haoyu Shih, Nien-Chu Sepehrband, Farshid Choupan, Jeiran Neuroimage Article In this article, we provide an overview of current neuroimaging methods for studying perivascular spaces (PVS) in humans using brain MRI. In recent years, an increasing number of studies highlighted the role of PVS in cerebrospinal/interstial fluid circulation and clearance of cerebral waste products and their association with neurological diseases. Novel strategies and techniques have been introduced to improve the quantification of PVS and to investigate their function and morphological features in physiological and pathological conditions. After a brief introduction on the anatomy and physiology of PVS, we examine the latest technological developments to quantitatively analyze the structure and function of PVS in humans with MRI. We describe the applications, advantages, and limitations of these methods, providing guidance and suggestions on the acquisition protocols and analysis techniques that can be applied to study PVS in vivo. Finally, we review the human neuroimaging studies on PVS across the normative lifespan and in the context of neurological disorders. 2022-08-15 2022-05-21 /pmc/articles/PMC9233116/ /pubmed/35609770 http://dx.doi.org/10.1016/j.neuroimage.2022.119329 Text en https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) ) |
spellingShingle | Article Barisano, Giuseppe Lynch, Kirsten M. Sibilia, Francesca Lan, Haoyu Shih, Nien-Chu Sepehrband, Farshid Choupan, Jeiran Imaging perivascular space structure and function using brain MRI |
title | Imaging perivascular space structure and function using brain MRI |
title_full | Imaging perivascular space structure and function using brain MRI |
title_fullStr | Imaging perivascular space structure and function using brain MRI |
title_full_unstemmed | Imaging perivascular space structure and function using brain MRI |
title_short | Imaging perivascular space structure and function using brain MRI |
title_sort | imaging perivascular space structure and function using brain mri |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9233116/ https://www.ncbi.nlm.nih.gov/pubmed/35609770 http://dx.doi.org/10.1016/j.neuroimage.2022.119329 |
work_keys_str_mv | AT barisanogiuseppe imagingperivascularspacestructureandfunctionusingbrainmri AT lynchkirstenm imagingperivascularspacestructureandfunctionusingbrainmri AT sibiliafrancesca imagingperivascularspacestructureandfunctionusingbrainmri AT lanhaoyu imagingperivascularspacestructureandfunctionusingbrainmri AT shihnienchu imagingperivascularspacestructureandfunctionusingbrainmri AT sepehrbandfarshid imagingperivascularspacestructureandfunctionusingbrainmri AT choupanjeiran imagingperivascularspacestructureandfunctionusingbrainmri |