β2-Adrenergic receptor agonist enhances the bystander effect of HSV-TK/GCV gene therapy in glioblastoma multiforme via upregulation of connexin 43 expression

Glioblastoma multiforme (GBM) is the most invasive form of primary brain astrocytoma. Gene therapy using the herpes simplex virus thymidine kinase/ganciclovir (HSV-TK/GCV) is a new strategy for GBM treatment. As the connexin 43 (Cx43) levels are downregulated in GBM cells, it seems that the upregula...

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Detalles Bibliográficos
Autores principales: Hosseindoost, Saereh, Mousavi, Seyed Mojtaba, Dehpour, Ahmad Reza, Javadi, Seyed Amirhossein, Arjmand, Babak, Fallah, Ali, Hadjighassem, Mahmoudreza
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9233183/
https://www.ncbi.nlm.nih.gov/pubmed/35795095
http://dx.doi.org/10.1016/j.omto.2022.05.010

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9233183/
https://www.ncbi.nlm.nih.gov/pubmed/35795095
http://dx.doi.org/10.1016/j.omto.2022.05.010

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